Entity Details

Primary name VAV_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15498
EntryNameVAV_HUMAN
FullNameProto-oncogene vav
TaxID9606
Evidenceevidence at protein level
Length845
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesVAV1

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008361 regulation of cell size
GO:0019221 cytokine-mediated signaling pathway
GO:0030168 platelet activation
GO:0030217 T cell differentiation
GO:0030593 neutrophil chemotaxis
GO:0031295 T cell costimulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051897 positive regulation of protein kinase B signaling
GO:0072593 reactive oxygen species metabolic process
GO:0140031 phosphorylation-dependent protein binding

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003096 Smooth muscle protein/calponinFamilyFamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domainDomainDomain
IPR028530 Protein vav1FamilyFamily
IPR035729 VAV1 protein, second SH3 domainDomainDomain
IPR035730 VAV1 protein, first SH3 domainDomainDomain
IPR035879 VAV1, SH2 domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR037832 Vav, PH domainDomainDomain

Diseases

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Interactions

89 interactions

InteractorPartnerSourcesPublicationsLink
VAV_HUMANZN655_HUMANBioGRID, HPRD, IntAct15558030 details
VAV_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10207103 15558030 16339550 18692475 29997244 32203420 7809090 8647120 8900182 9013873 details
VAV_HUMAN3BP2_HUMANBioGRID, HPRD, MINT11390470 15345594 17306257 20439986 details
VAV_HUMANRAC1_HUMANBioGRID, HPRD, MINT11287617 16397238 18511940 32203420 details
VAV_HUMANRHOA_HUMANBioGRID, HPRD, MINT16397238 18511940 32203420 details
VAV_HUMANCDC42_HUMANBioGRID, HPRD, MINT11287617 18511940 32203420 details
VAV_HUMANABL1_HUMANBioGRID, MINT11790798 19234221 details
VAV_HUMANKHDR1_HUMANBioGRID, MINT17855053 22745667 details
VAV_HUMANABI1_HUMANMINT20598684 details
VAV_HUMANLCP2_HUMANBioGRID, HPRD, MINT10347175 11331248 19635790 21725281 8673706 8703037 9047237 9341187 details
VAV_HUMANP85A_HUMANBioGRID, MINT17050525 9162069 9891995 details
VAV_HUMANZAP70_HUMANBioGRID, HPRD, MINT16339550 7798261 8530437 9151714 details
VAV_HUMANCBL_HUMANBioGRID, HPRD, MINT11133830 11331248 12881521 16289966 16356860 18835194 19635790 9200440 details
VAV_HUMANPHAX_HUMANBioGRID, MINT21900206 details
VAV_HUMANANDR_HUMANBioGRID, IntAct24728074 details
VAV_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
VAV_HUMANEGFR_HUMANBioGRID, HPRD, IntAct10938113 16273093 22973453 24658140 25402006 31980649 details
VAV_HUMANTBA1A_HUMANBioGRID, IntAct31980649 8530437 details
VAV_HUMANXRCC6_HUMANBioGRID, HPRD8524317 details
VAV_HUMANEZH2_HUMANBioGRID, HPRD10780782 15882624 8649418 details
VAV_HUMANEMD_HUMANBioGRID12755701 details
VAV_HUMANPLCG1_HUMANBioGRID, HPRD16467851 9891995 details
VAV_HUMANPRLR_HUMANBioGRID, HPRD11328862 7768923 details
VAV_HUMANJUN_HUMANBioGRID11287617 details
VAV_HUMANSOCS1_HUMANBioGRID, HPRD10022833 10747851 29991678 details
VAV_HUMANJAK2_HUMANBioGRID, HPRD7530656 9162069 details
VAV_HUMANPGFRB_HUMANBioGRID10938113 22974441 details
VAV_HUMANSLAP1_HUMANBioGRID, HPRD10662792 details
VAV_HUMANSHB_HUMANBioGRID, HPRD12084069 details
VAV_HUMANLAT_HUMANBioGRID, HPRD11368773 12186560 details
VAV_HUMANRGAP1_HUMANBioGRID, HPRD10748082 details
VAV_HUMANKSYK_HUMANBioGRID, HPRD11262396 11331248 8900182 8986718 details
VAV_HUMANGDIR2_HUMANBioGRID, HPRD10664460 details
VAV_HUMANFYN_HUMANBioGRID, HPRD11262396 9822663 details
VAV_HUMANHNRPK_HUMANBioGRID, HPRD7862126 8051112 details
VAV_HUMANPHAG1_HUMANBioGRID, HPRD10790433 details
VAV_HUMANCBLB_HUMANBioGRID, HPRD11857085 9399639 details
VAV_HUMANCD19_HUMANBioGRID, HPRD15187135 16289966 7528218 details
VAV_HUMANPTN6_HUMANBioGRID, HPRD8632004 details
VAV_HUMANSIAH2_HUMANBioGRID, HPRD10207103 details
VAV_HUMANSIAH1_HUMANBioGRID10207103 details
VAV_HUMANIL6RB_HUMANBioGRID, HPRD9013873 details
VAV_HUMANS100B_HUMANBioGRID10394361 details
VAV_HUMANFAK2_HUMANBioGRID, HPRD10867021 details
VAV_HUMANINSR_HUMANBioGRID, HPRD7535775 details
VAV_HUMANFGFR1_HUMANBioGRID22974441 details
VAV_HUMANDOK1_HUMANBioGRID22974441 details
VAV_HUMANERBB2_HUMANBioGRID16273093 22973453 details
VAV_HUMANERBB3_HUMANBioGRID16273093 22973453 details
VAV_HUMANERBB4_HUMANBioGRID22973453 details
VAV_HUMANZYX_HUMANHPRD8622875 details
VAV_HUMANMET_HUMANHPRD15546961 details
VAV_HUMANMERTK_HUMANHPRD12920122 details
VAV_HUMANBCR_HUMANHPRD11790798 details
VAV_HUMANCRK_HUMANHPRD, MINT8621483 details
VAV_HUMANITB2_HUMANMINT19234221 details
VAV_HUMANLCK_HUMANHPRD, MINT10669745 17050525 details
VAV_HUMANTBB5_HUMANBioGRID, IntAct31980649 8530437 9880513 details
VAV_HUMANKPCT_HUMANBioGRID, HPRD10725744 details
VAV_HUMANBLNK_HUMANBioGRID, HPRD9697839 details
VAV_HUMANXRCC5_HUMANBioGRID, HPRD10673353 details
VAV_HUMANTYK2_HUMANBioGRID, HPRD10673353 details
VAV_HUMANTEC_HUMANBioGRID, HPRD11328862 7651724 details
VAV_HUMANEPOR_HUMANBioGRID, HPRD9162069 details
VAV_HUMANBTK_HUMANBioGRID, HPRD9201297 details
VAV_HUMANRAF1_HUMANBioGRID, HPRD8900182 details
VAV_HUMANMK01_HUMANBioGRID, HPRD8900182 9013873 details
VAV_HUMANMP2K1_HUMANBioGRID8900182 details
VAV_HUMANPLCG2_HUMANBioGRID10981967 details
VAV_HUMANDOCK2_HUMANBioGRID, HPRD12393632 details
VAV_HUMANSUZ12_HUMANBioGRID15882624 details
VAV_HUMANEED_HUMANBioGRID15882624 details
VAV_HUMANCD5_HUMANBioGRID23376399 details
VAV_HUMANSPI1_HUMANBioGRID19747912 details
VAV_HUMANCD28_HUMANBioGRID9620604 details
VAV_HUMANFCERB_HUMANBioGRID8900182 details
VAV_HUMANRHOG_HUMANHPRD12376551 details
VAV_HUMANRASH_HUMANHPRD8554611 details
VAV_HUMANAOC3_HUMANHPRD1375396 details
VAV_HUMANNEK3_HUMANHPRD15618286 details
VAV_HUMANCASP3_HUMANHPRD10713703 details
VAV_HUMANGDIR1_HUMANHPRD10664460 details
VAV_HUMANACTS_HUMANHPRD11839310 details
VAV_HUMANHCK_HUMANHPRD9400828 details
VAV_HUMANCXCR4_HUMANHPRD15618472 details
VAV_HUMANTBA4A_HUMANHPRD8530437 details
VAV_HUMANTBB2A_HUMANHPRD8530437 details
VAV_HUMANDYN2_HUMANHPRD15696170 details
VAV_HUMANSHC1_HUMANHPRD15688026 details