Entity Details

Primary name NQO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15559
EntryNameNQO1_HUMAN
FullNameNAD(P)H dehydrogenase [quinone] 1
TaxID9606
Evidenceevidence at protein level
Length274
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesNQO1

GO terms

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GOName
GO:0002931 response to ischemia
GO:0003723 RNA binding
GO:0003955 NAD(P)H dehydrogenase (quinone) activity
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0004784 superoxide dismutase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006116 NADH oxidation
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006979 response to oxidative stress
GO:0007271 synaptic transmission, cholinergic
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008753 NADPH dehydrogenase (quinone) activity
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0014075 response to amine
GO:0030425 dendrite
GO:0032355 response to estradiol
GO:0033574 response to testosterone
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0043279 response to alkaloid
GO:0043525 positive regulation of neuron apoptotic process
GO:0045202 synapse
GO:0045454 cell redox homeostasis
GO:0045471 response to ethanol
GO:0050136 NADH dehydrogenase (quinone) activity
GO:0051602 response to electrical stimulus
GO:0070301 cellular response to hydrogen peroxide
GO:0070995 NADPH oxidation
GO:0071248 cellular response to metal ion
GO:1904772 response to tetrachloromethane
GO:1904844 response to L-glutamine
GO:1904880 response to hydrogen sulfide
GO:1905395 response to flavonoid

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003680 Flavodoxin-like foldDomainDomain
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00170 MenadioneDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00266 DicoumarolDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01927 DuroquinoneDrugbanksmall molecule
DB02395 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-PropanolDrugbanksmall molecule
DB02400 ES-936Drugbanksmall molecule
DB02633 Cibacron BlueDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB03626 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-DioneDrugbanksmall molecule
DB04090 RH-1Drugbanksmall molecule
DB04392 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]Drugbanksmall molecule
DB07385 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONEDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule