Entity Details

Primary name ANK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16157
EntryNameANK1_HUMAN
FullNameAnkyrin-1
TaxID9606
Evidenceevidence at protein level
Length1881
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesANK1

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006887 exocytosis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0008093 cytoskeletal anchor activity
GO:0009898 cytoplasmic side of plasma membrane
GO:0010638 positive regulation of organelle organization
GO:0014731 spectrin-associated cytoskeleton
GO:0016323 basolateral plasma membrane
GO:0016529 sarcoplasmic reticulum
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030018 Z disc
GO:0030507 spectrin binding
GO:0030673 axolemma
GO:0031430 M band
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0044325 transmembrane transporter binding
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0045211 postsynaptic membrane
GO:0051117 ATPase binding
GO:0072659 protein localization to plasma membrane

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Sarcoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000906 ZU5 domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR040745 Ankyrin, UPA domainDomainDomain

Diseases

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Disease IDSourceNameDescription
182900 OMIMSpherocytosis 1 (SPH1)A form of spherocytosis, a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH1 is characterized by severe hemolytic anemia. Inheritance can be autosomal dominant or autosomal recessive. Patients with homozygous mutations have a more severe disorder. The disease is caused by variants affecting the gene represented in this entry.

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
ANK1_HUMANOBSCN_HUMANBioGRID, HPRD, IntAct, UniProt12527750 12631729 16962094 22573887 details
ANK1_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
ANK1_HUMANRBFA_HUMANBioGRID, IntAct32296183 details
ANK1_HUMANEMP1_HUMANBioGRID, IntAct32296183 details
ANK1_HUMANTM203_HUMANBioGRID, IntAct32296183 details
ANK1_HUMANEMD_HUMANBioGRID, IntAct32296183 details
ANK1_HUMANFXYD3_HUMANBioGRID, IntAct32296183 details
ANK1_HUMANRTP2_HUMANBioGRID, IntAct32296183 details
ANK1_HUMANZNT8_HUMANBioGRID, IntAct32296183 details
ANK1_HUMANNRM_HUMANBioGRID, IntAct32296183 details
ANK1_HUMANDWORF_HUMANIntAct32296183 details
ANK1_HUMANRHAG_HUMANBioGRID, HPRD12719424 details
ANK1_HUMANSPTB1_HUMANBioGRID2141335 details
ANK1_HUMANTITIN_HUMANBioGRID, HPRD12444090 16962094 details
ANK1_HUMANSPTA1_HUMANBioGRID15929114 2971657 details
ANK1_HUMANTIAM1_HUMANBioGRID, HPRD10893266 details
ANK1_HUMANKCTD6_HUMANBioGRID22573887 details
ANK1_HUMANCD44_HUMANBioGRID, HPRD15051494 7505012 9519902 details
ANK1_HUMANRYR1_HUMANBioGRID7629097 details
ANK1_HUMANB3AT_HUMANBioGRID, HPRD27742708 6449514 8227202 details
ANK1_HUMANB3A3_HUMANBioGRID, HPRD8227202 details
ANK1_HUMANCUL3_HUMANBioGRID22573887 details
ANK1_HUMANSPTB2_HUMANBioGRID12543979 details
ANK1_HUMANTGFR1_HUMANBioGRID12543979 details
ANK1_HUMANEPB42_HUMANHPRD2968981 details
ANK1_HUMANSPTN1_HUMANHPRD2141335 2970468 2971657 492324 details
ANK1_HUMANL1CAM_HUMANHPRD11222639 details
ANK1_HUMANNBPF3_HUMANHPRD9587054 details
ANK1_HUMANNFASC_HUMANHPRD9804856 details
ANK1_HUMANBL1S6_HUMANHPRD12019270 details
ANK1_HUMANITPR3_HUMANHPRD15051494 8385102 details