Entity Details

Primary name SPI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17947
EntryNameSPI1_HUMAN
FullNameTranscription factor PU.1
TaxID9606
Evidenceevidence at protein level
Length270
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesSPI1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001216 DNA-binding transcription activator activity
GO:0001217 DNA-binding transcription repressor activity
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002314 germinal center B cell differentiation
GO:0002316 follicular B cell differentiation
GO:0002327 immature B cell differentiation
GO:0002357 defense response to tumor cell
GO:0002572 pro-T cell differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030225 macrophage differentiation
GO:0030851 granulocyte differentiation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034401 chromatin organization involved in regulation of transcription
GO:0035019 somatic stem cell population maintenance
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0042826 histone deacetylase binding
GO:0043011 myeloid dendritic cell differentiation
GO:0043314 negative regulation of neutrophil degranulation
GO:0043966 histone H3 acetylation
GO:0044027 hypermethylation of CpG island
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045646 regulation of erythrocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051525 NFAT protein binding
GO:0060033 anatomical structure regression
GO:0070102 interleukin-6-mediated signaling pathway
GO:0071361 cellular response to ethanol
GO:0090241 negative regulation of histone H4 acetylation
GO:0090402 oncogene-induced cell senescence
GO:0098508 endothelial to hematopoietic transition
GO:0120186 negative regulation of protein localization to chromatin
GO:0140297 DNA-binding transcription factor binding
GO:0140311 protein sequestering activity
GO:1900745 positive regulation of p38MAPK cascade
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901674 regulation of histone H3-K27 acetylation
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904151 positive regulation of microglial cell mediated cytotoxicity
GO:1904178 negative regulation of adipose tissue development
GO:1904238 pericyte cell differentiation
GO:1905036 positive regulation of antifungal innate immune response
GO:1905453 regulation of myeloid progenitor cell differentiation
GO:2000529 positive regulation of myeloid dendritic cell chemotaxis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000418 Ets domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
SPI1_HUMANTMX1_HUMANBioGRID, IntAct21988832 details
SPI1_HUMANPRKDC_HUMANIntAct21575865 details
SPI1_HUMANGFI1_HUMANBioGRID, UniProt17197705 details
SPI1_HUMANGATA2_HUMANBioGRID, DIP, HPRD10364157 10411939 18250304 details
SPI1_HUMANCSK21_HUMANBioGRID8632909 details
SPI1_HUMANMK08_HUMANBioGRID8632909 details
SPI1_HUMANCREM_HUMANBioGRID, HPRD7730336 details
SPI1_HUMANATF1_HUMANBioGRID, HPRD7730336 details
SPI1_HUMANETS1_HUMANBioGRID9681824 details
SPI1_HUMANETS2_HUMANBioGRID9681824 details
SPI1_HUMANETV1_HUMANBioGRID9681824 details
SPI1_HUMANFOS_HUMANBioGRID9681824 details
SPI1_HUMANJUN_HUMANBioGRID, HPRD12091339 9681824 details
SPI1_HUMANCEBPB_HUMANBioGRID, HPRD7594592 details
SPI1_HUMANFUS_HUMANBioGRID, HPRD9478924 details
SPI1_HUMANSPIB_HUMANBioGRID, HPRD10196196 details
SPI1_HUMANNONO_HUMANBioGRID, HPRD8626664 details
SPI1_HUMANMITF_HUMANBioGRID, HPRD9918847 details
SPI1_HUMANIRF4_HUMANBioGRID, HPRD10022840 12372320 details
SPI1_HUMANNFYA_HUMANBioGRID9668064 details
SPI1_HUMANCEBPA_HUMANBioGRID, HPRD12091339 16983342 details
SPI1_HUMANMECP2_HUMANBioGRID14647463 16331260 details
SPI1_HUMANHDAC1_HUMANBioGRID11593411 14647463 16331260 details
SPI1_HUMANDNM3A_HUMANBioGRID, HPRD16331260 details
SPI1_HUMANDNM3B_HUMANBioGRID, HPRD16331260 details
SPI1_HUMANBCL6_HUMANBioGRID19564417 details
SPI1_HUMANTBP_HUMANBioGRID, HPRD11593411 8434021 details
SPI1_HUMANSIN3A_HUMANBioGRID11593411 details
SPI1_HUMANSKI_HUMANBioGRID17621263 details
SPI1_HUMANGATA1_HUMANBioGRID, HPRD10364157 12202480 details
SPI1_HUMANIRF1_HUMANBioGRID11483597 9593745 details
SPI1_HUMANIRF8_HUMANBioGRID, HPRD10734131 11483597 17200120 9593745 details
SPI1_HUMANRB_HUMANBioGRID, HPRD8434021 details
SPI1_HUMANGATA3_HUMANBioGRID10364157 details
SPI1_HUMANRUNX1_HUMANBioGRID10207087 details
SPI1_HUMANIRF2_HUMANBioGRID17200120 details
SPI1_HUMANCBP_HUMANHPRD10050886 details
SPI1_HUMANHXA10_HUMANBioGRID, HPRD, IntAct18692240 details
SPI1_HUMANKPCD_HUMANMINT24996056 details
SPI1_HUMANHDAC3_HUMANBioGRID17621263 details
SPI1_HUMANRARA_HUMANBioGRID20159610 details
SPI1_HUMANPML_HUMANBioGRID20159610 details
SPI1_HUMANVAV_HUMANBioGRID19747912 details
SPI1_HUMANERG_HUMANHPRD9681824 details
SPI1_HUMANCEBPE_HUMANHPRD12202480 details
SPI1_HUMANNFAC1_HUMANHPRD15304486 details
SPI1_HUMANPIP_HUMANHPRD11133986 details
SPI1_HUMANSSRP1_HUMANHPRD7594592 details
SPI1_HUMANCEBPD_HUMANHPRD7594592 details
SPI1_HUMANKAT6A_HUMANHPRD16702405 details
SPI1_HUMANNFKB1_HUMANHPRD9094628 details