Entity Details

Primary name PRS6A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17980
EntryNamePRS6A_HUMAN
FullName26S proteasome regulatory subunit 6A
TaxID9606
Evidenceevidence at protein level
Length439
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesPSMC3

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0016887 ATP hydrolysis activity
GO:0022624 proteasome accessory complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034774 secretory granule lumen
GO:0036388 pre-replicative complex assembly
GO:0036402 proteasome-activating activity
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042802 identical protein binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043312 neutrophil degranulation
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0043921 modulation by host of viral transcription
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR005937 26S proteasome regulatory subunit P45-likeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032501 Proteasomal ATPase OB C-terminal domainDomainDomain
IPR035254 26S Proteasome regulatory subunit 6AFamilyFamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12695 Phenethyl IsothiocyanateDrugbanksmall molecule

Interactions

81 interactions

InteractorPartnerSourcesPublicationsLink
PRS6A_HUMANSTX11_HUMANBioGRID, HPRD, IntAct16169070 details
PRS6A_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 32814053 details
PRS6A_HUMANPRS6B_HUMANBioGRID, HPRD, IntAct11463857 17353931 22275368 22863883 22939629 26186194 26344197 28292943 28514442 8419915 details
PRS6A_HUMANPSMD4_HUMANBioGRID, DIP, MINT16990800 22939629 26344197 28292943 30479383 details
PRS6A_HUMANMYC_HUMANBioGRID, IntAct17314511 21988832 29467282 details
PRS6A_HUMANPSMD9_HUMANBioGRID, IntAct19490896 25416956 26186194 26344197 28292943 28514442 31515488 32296183 details
PRS6A_HUMANPRS10_HUMANBioGRID, DIP, IntAct19490896 22275368 22863883 22939629 25416956 26186194 26344197 27342858 28292943 28514442 29636472 32296183 details
PRS6A_HUMANPRS8_HUMANBioGRID, HPRD, IntAct11463857 19490896 20431057 20810900 22275368 22939629 26186194 26344197 28292943 28514442 details
PRS6A_HUMANPSMD7_HUMANBioGRID, IntAct19615732 22939629 26344197 28292943 28514442 details
PRS6A_HUMANGA45A_HUMANBioGRID, IntAct21988832 details
PRS6A_HUMANCAN3_HUMANBioGRID, IntAct23414517 details
PRS6A_HUMANPRS7_HUMANBioGRID, IntAct21628461 22275368 22863883 22901813 22939629 26344197 28292943 28514442 9464850 details
PRS6A_HUMANAMOL2_HUMANBioGRID, IntAct24255178 25416956 32296183 details
PRS6A_HUMANPRS6A_HUMANBioGRID, HPRD, IntAct11463857 21675959 25416956 28292943 32296183 8419915 details
PRS6A_HUMANTRAF4_HUMANBioGRID, IntAct16969126 26186194 28514442 32296183 details
PRS6A_HUMANDPY30_HUMANBioGRID, IntAct32296183 details
PRS6A_HUMANFBX28_HUMANBioGRID, IntAct26186194 28514442 32296183 details
PRS6A_HUMANACPM_HUMANBioGRID, IntAct32296183 details
PRS6A_HUMANKCRU_HUMANBioGRID, IntAct32296183 details
PRS6A_HUMANPSD12_HUMANBioGRID, IntAct22939629 26186194 26344197 28292943 28514442 details
PRS6A_HUMANPAR2_HUMANBioGRID, MINT28298427 details
PRS6A_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
PRS6A_HUMANDCTN1_HUMANIntAct32814053 details
PRS6A_HUMANHTRA2_HUMANIntAct32814053 details
PRS6A_HUMANSODC_HUMANIntAct32814053 details
PRS6A_HUMANA4_HUMANIntAct32814053 details
PRS6A_HUMANSYUA_HUMANBioGRID, IntAct12551928 15591046 32814053 details
PRS6A_HUMANHD_HUMANIntAct32814053 details
PRS6A_HUMANTRXR2_HUMANBioGRID11463857 details
PRS6A_HUMANVHL_HUMANBioGRID, HPRD14556007 details
PRS6A_HUMANCDN2A_HUMANBioGRID14665636 17334400 details
PRS6A_HUMANARF_HUMANBioGRID, HPRD14665636 17334400 details
PRS6A_HUMANUBC_HUMANBioGRID16196087 24743594 28190767 details
PRS6A_HUMANMDM2_HUMANBioGRID20479273 22659184 details
PRS6A_HUMANINSI2_HUMANBioGRID19815544 details
PRS6A_HUMANINSI1_HUMANBioGRID19815544 details
PRS6A_HUMANHOP2_HUMANBioGRID, HPRD19325002 9345291 details
PRS6A_HUMANUBC9_HUMANBioGRID17709345 details
PRS6A_HUMANTXNL1_HUMANBioGRID19349277 28292943 details
PRS6A_HUMANKDM1A_HUMANBioGRID25416956 details
PRS6A_HUMANUBE3A_HUMANBioGRID22645313 24743594 29426014 30257870 details
PRS6A_HUMANEPM2A_HUMANBioGRID26493215 details
PRS6A_HUMANSUMO2_HUMANBioGRID32786267 details
PRS6A_HUMANASXL1_HUMANBioGRID32683582 details
PRS6A_HUMANOGT1_HUMANBioGRID32994395 details
PRS6A_HUMANPSMD6_HUMANBioGRID, IntAct17353931 22275368 22939629 26186194 26344197 28514442 details
PRS6A_HUMANPAAF1_HUMANBioGRID, IntAct15831487 17353931 details
PRS6A_HUMANSOMA_HUMANIntAct17353931 details
PRS6A_HUMANAAKB1_HUMANIntAct17353931 details
PRS6A_HUMANPSDE_HUMANBioGRID, IntAct17323924 22863883 22939629 24743594 26344197 26496610 27428775 28821611 30745168 details
PRS6A_HUMANPRS4_HUMANBioGRID, IntAct21628461 22275368 22863883 22939629 26186194 26344197 26496610 28514442 details
PRS6A_HUMANINTU_HUMANBioGRID, IntAct27173435 unassigned1312 details
PRS6A_HUMANPSMD1_HUMANBioGRID, IntAct22275368 22863883 22939629 26186194 26344197 28514442 details
PRS6A_HUMANPSMD2_HUMANBioGRID, IntAct22275368 22863883 22939629 26186194 26344197 28514442 details
PRS6A_HUMANFMR1_HUMANIntAct31413325 details
PRS6A_HUMANFXR1_HUMANMINT21653829 details
PRS6A_HUMANHIF1A_HUMANBioGRID14556007 details
PRS6A_HUMANEPAS1_HUMANBioGRID14556007 details
PRS6A_HUMANPMS2_HUMANBioGRID17148452 details
PRS6A_HUMANJKAMP_HUMANBioGRID19269966 23798571 details
PRS6A_HUMANP53_HUMANBioGRID20479273 details
PRS6A_HUMANUBD_HUMANBioGRID22072791 details
PRS6A_HUMANC2TA_HUMANBioGRID20351748 details
PRS6A_HUMANPSA3_HUMANBioGRID11139393 22079093 22939629 26344197 details
PRS6A_HUMANSEM1_HUMANBioGRID16239144 28396413 details
PRS6A_HUMANSEML_HUMANBioGRID16239144 28396413 details
PRS6A_HUMANM3K5_HUMANBioGRID20843792 details
PRS6A_HUMANRD23A_HUMANBioGRID19013454 details
PRS6A_HUMANPRKN_HUMANBioGRID20810900 23503661 details
PRS6A_HUMANFKBP8_HUMANBioGRID17573772 details
PRS6A_HUMANPSMD8_HUMANBioGRID21628461 22275368 22939629 26344197 details
PRS6A_HUMANPSB5_HUMANBioGRID21628461 22939629 26344197 details
PRS6A_HUMANFOSL1_HUMANBioGRID21874050 details
PRS6A_HUMANSTAT1_HUMANBioGRID19853614 details
PRS6A_HUMANANDR_HUMANBioGRID19325002 32814769 details
PRS6A_HUMANSYN2_HUMANBioGRID11032911 details
PRS6A_HUMANBAX_HUMANBioGRID20431057 details
PRS6A_HUMANPSA2_HUMANBioGRID19193609 22939629 26344197 details
PRS6A_HUMANCSN2_HUMANBioGRID19535905 details
PRS6A_HUMANPSA1_HUMANBioGRID22939629 26344197 30254168 details
PRS6A_HUMANFGF11_HUMANBioGRID28027390 details