Entity Details

Primary name ERCC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18074
EntryNameERCC2_HUMAN
FullNameGeneral transcription and DNA repair factor IIH helicase subunit XPD
TaxID9606
Evidenceevidence at protein level
Length760
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesERCC2

GO terms

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GOName
GO:0000439 transcription factor TFIIH core complex
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007059 chromosome segregation
GO:0007568 aging
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0009411 response to UV
GO:0009650 UV protection
GO:0009791 post-embryonic development
GO:0016032 viral process
GO:0021510 spinal cord development
GO:0030198 extracellular matrix organization
GO:0030282 bone mineralization
GO:0030674 protein-macromolecule adaptor activity
GO:0032289 central nervous system myelin formation
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035264 multicellular organism growth
GO:0035315 hair cell differentiation
GO:0040016 embryonic cleavage
GO:0043139 5'-3' DNA helicase activity
GO:0043249 erythrocyte maturation
GO:0043388 positive regulation of DNA binding
GO:0045951 positive regulation of mitotic recombination
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0048568 embryonic organ development
GO:0048820 hair follicle maturation
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0060218 hematopoietic stem cell differentiation
GO:0070516 CAK-ERCC2 complex
GO:0070911 global genome nucleotide-excision repair
GO:0071817 MMXD complex
GO:1901990 regulation of mitotic cell cycle phase transition

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001945 RAD3/XPD familyFamilyFamily
IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved siteSiteConserved site
IPR006554 Helicase-like, DEXD box c2 typeDomainDomain
IPR006555 ATP-dependent helicase, C-terminalDomainDomain
IPR010614 DEAD2DomainDomain
IPR010643 Helical and beta-bridge domainDomainDomain
IPR013020 ATP-dependent helicase Rad3/Chl1-likeFamilyFamily
IPR014013 Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-typeDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
ERCC2_HUMANT2H2L_HUMANBioGRID, IntAct25416956 details
ERCC2_HUMANTF2H1_HUMANBioGRID, HPRD, IntAct11071939 26340423 8152490 8652557 9130708 details
ERCC2_HUMANMAT1_HUMANBioGRID, IntAct10801852 22939629 26186194 26340423 28514442 32245994 details
ERCC2_HUMANERCC3_HUMANBioGRID, DIP, HPRD, IntAct15220921 16669699 19934020 22678362 22939629 26340423 27193682 8152490 8652557 9118947 details
ERCC2_HUMANT2EA_HUMANBioGRID, DIP25492609 27193682 details
ERCC2_HUMANTF2H2_HUMANBioGRID, DIP, HPRD, IntAct11062469 12820975 19934020 26340423 27193682 9771713 details
ERCC2_HUMANTF2H3_HUMANBioGRID, DIP21157430 27193682 details
ERCC2_HUMANP53_HUMANBioGRID7663514 8612585 details
ERCC2_HUMANERCC5_HUMANBioGRID, HPRD32245994 8652557 details
ERCC2_HUMANHERC5_HUMANBioGRID16884686 details
ERCC2_HUMANTRI25_HUMANBioGRID16884686 details
ERCC2_HUMANANDR_HUMANBioGRID21157430 details
ERCC2_HUMANCDK7_HUMANBioGRID, HPRD, IntAct11445587 22939629 23602568 26186194 28514442 29568061 8692841 details
ERCC2_HUMANHSF2_HUMANIntAct25036637 details
ERCC2_HUMANNUDC3_HUMANIntAct25036637 details
ERCC2_HUMANSTIP1_HUMANIntAct25036637 details
ERCC2_HUMANCYBP_HUMANIntAct25036637 details
ERCC2_HUMANPTG3L_HUMANIntAct25036637 details
ERCC2_HUMANAASD1_HUMANIntAct25036637 details
ERCC2_HUMANMMS19_HUMANBioGRID, IntAct11071939 22678361 22678362 23585563 28178521 details
ERCC2_HUMANCIAO1_HUMANBioGRID, IntAct23585563 23891004 28178521 details
ERCC2_HUMANCIA2B_HUMANBioGRID, IntAct23585563 23891004 28178521 details
ERCC2_HUMANCCNH_HUMANBioGRID, IntAct22939629 26186194 26340423 28514442 8692842 details
ERCC2_HUMANRPB1_HUMANBioGRID, DIP27193682 32355176 details
ERCC2_HUMANT2FA_HUMANBioGRID, DIP27193682 9121429 details
ERCC2_HUMANISG15_HUMANBioGRID16884686 details
ERCC2_HUMANMCAF1_HUMANBioGRID19106100 details
ERCC2_HUMANERPG3_HUMANBioGRID20541997 details
ERCC2_HUMANERCC6_HUMANBioGRID20541997 details
ERCC2_HUMANRAD52_HUMANBioGRID, HPRD12372413 details
ERCC2_HUMANUVSSA_HUMANBioGRID22902626 32355176 details
ERCC2_HUMANSPTA1_HUMANBioGRID16889989 details
ERCC2_HUMANMD2L1_HUMANBioGRID18597777 details
ERCC2_HUMANXPA_HUMANBioGRID18597777 details
ERCC2_HUMANRAD51_HUMANBioGRID, HPRD12359753 18597777 details
ERCC2_HUMANCDK1_HUMANHPRD8652557 details
ERCC2_HUMANERCC2_HUMANHPRD11062469 11266437 15220921 details