Entity Details

Primary name NR1D1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20393
EntryNameNR1D1_HUMAN
FullNameNuclear receptor subfamily 1 group D member 1
TaxID9606
Evidenceevidence at protein level
Length614
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesNR1D1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 transcription corepressor binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001678 cellular glucose homeostasis
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005978 glycogen biosynthetic process
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007623 circadian rhythm
GO:0008270 zinc ion binding
GO:0009755 hormone-mediated signaling pathway
GO:0010498 proteasomal protein catabolic process
GO:0016604 nuclear body
GO:0019216 regulation of lipid metabolic process
GO:0020037 heme binding
GO:0030154 cell differentiation
GO:0030425 dendrite
GO:0031648 protein destabilization
GO:0032922 circadian regulation of gene expression
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0042632 cholesterol homeostasis
GO:0042749 regulation of circadian sleep/wake cycle
GO:0042752 regulation of circadian rhythm
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043197 dendritic spine
GO:0044321 response to leptin
GO:0045598 regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0060086 circadian temperature homeostasis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061469 regulation of type B pancreatic cell proliferation
GO:0061889 negative regulation of astrocyte activation
GO:0070859 positive regulation of bile acid biosynthetic process
GO:0070888 E-box binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0150079 negative regulation of neuroinflammatory response
GO:1903979 negative regulation of microglial cell activation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB14013 SR-9009Drugbanksmall molecule
DB14014 SR-9011Drugbanksmall molecule