Entity Details

Primary name BCL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20749
EntryNameBCL3_HUMAN
FullNameB-cell lymphoma 3 protein
TaxID9606
Evidenceevidence at protein level
Length454
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesBCL3

GO terms

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GOName
GO:0002268 follicular dendritic cell differentiation
GO:0002315 marginal zone B cell differentiation
GO:0002455 humoral immune response mediated by circulating immunoglobulin
GO:0002467 germinal center formation
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008134 transcription factor binding
GO:0009615 response to virus
GO:0010225 response to UV-C
GO:0019730 antimicrobial humoral response
GO:0030198 extracellular matrix organization
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030496 midbody
GO:0030674 protein-macromolecule adaptor activity
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032991 protein-containing complex
GO:0032996 Bcl3-Bcl10 complex
GO:0033257 Bcl3/NF-kappaB2 complex
GO:0042088 T-helper 1 type immune response
GO:0042742 defense response to bacterium
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042832 defense response to protozoan
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045064 T-helper 2 cell differentiation
GO:0045727 positive regulation of translation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0048471 perinuclear region of cytoplasm
GO:0048536 spleen development
GO:0051101 regulation of DNA binding
GO:0051457 maintenance of protein location in nucleus
GO:1901222 regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002110 Ankyrin repeatRepeatRepeat
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
BCL3_HUMANFYN_HUMANBioGRID, HPRD, MINT16099425 9576921 details
BCL3_HUMANCTBP2_HUMANBioGRID, IntAct20547759 21988832 details
BCL3_HUMANANR28_HUMANBioGRID, IntAct23414517 details
BCL3_HUMANPIR_HUMANBioGRID, MINT10362352 25680527 details
BCL3_HUMANNFKB2_HUMANBioGRID, HPRD, IntAct11707390 14678988 17962807 20558726 20800578 28689659 30833792 8453667 details
BCL3_HUMANNFKB1_HUMANBioGRID, HPRD, IntAct10362352 10469655 14678988 15829968 17962807 20547759 20558726 20800578 30833792 8428580 details
BCL3_HUMANNUP58_HUMANIntAct32814053 details
BCL3_HUMANBARD1_HUMANBioGRID, HPRD10362352 details
BCL3_HUMANN4BP2_HUMANBioGRID, HPRD12730195 details
BCL3_HUMANKAT5_HUMANBioGRID, HPRD10362352 15829968 details
BCL3_HUMANCSN5_HUMANBioGRID, HPRD10362352 details
BCL3_HUMANJUN_HUMANBioGRID, HPRD10497212 details
BCL3_HUMANFOS_HUMANBioGRID, HPRD10497212 details
BCL3_HUMANEP300_HUMANBioGRID10497212 details
BCL3_HUMANNCOA1_HUMANBioGRID, HPRD10497212 details
BCL3_HUMANTBP_HUMANBioGRID, HPRD9812988 details
BCL3_HUMANRXRA_HUMANBioGRID, HPRD9812988 details
BCL3_HUMANTF2AA_HUMANBioGRID, HPRD9812988 details
BCL3_HUMANTF2B_HUMANBioGRID, HPRD9812988 details
BCL3_HUMANCTBP1_HUMANBioGRID20547759 20800578 details
BCL3_HUMANGSK3B_HUMANBioGRID, HPRD15469820 details
BCL3_HUMANMARE1_HUMANBioGRID24552808 details
BCL3_HUMANAKT1_HUMANBioGRID28689659 details
BCL3_HUMANIKKA_HUMANBioGRID28689659 details
BCL3_HUMANMK01_HUMANBioGRID28689659 details
BCL3_HUMANTRAF6_HUMANBioGRID29933112 details
BCL3_HUMANBCL10_HUMANBioGRID, IntAct16280327 details
BCL3_HUMANLCK_HUMANMINT16099425 details
BCL3_HUMANRELB_HUMANBioGRID14678988 details
BCL3_HUMANCYLD_HUMANBioGRID19893491 details
BCL3_HUMANSTAT1_HUMANBioGRID16306601 details
BCL3_HUMANSTAT3_HUMANBioGRID16306601 details
BCL3_HUMANHDAC1_HUMANBioGRID, HPRD15469820 16306601 details
BCL3_HUMANHSP74_HUMANBioGRID20547759 details
BCL3_HUMANTBL1R_HUMANBioGRID20547759 details
BCL3_HUMANBAG2_HUMANBioGRID20547759 details
BCL3_HUMANHDAC3_HUMANBioGRID, HPRD15469820 20547759 details
BCL3_HUMANRCOR1_HUMANBioGRID20547759 details
BCL3_HUMANKDM1A_HUMANBioGRID20547759 details
BCL3_HUMANHDAC6_HUMANBioGRID, HPRD15469820 details
BCL3_HUMANPSB1_HUMANBioGRID20558726 details
BCL3_HUMANFBXW8_HUMANBioGRID20558726 details
BCL3_HUMANCTNB1_HUMANBioGRID, HPRD15829968 details
BCL3_HUMANRUVB2_HUMANBioGRID, HPRD15829968 20800578 details
BCL3_HUMANESR1_HUMANBioGRID16331275 details
BCL3_HUMANRAB9A_HUMANHPRD11485202 11707390 details
BCL3_HUMANCBP_HUMANHPRD10497212 details
BCL3_HUMANSHC1_HUMANHPRD11707390 details
BCL3_HUMANGSK3A_HUMANHPRD15469820 details
BCL3_HUMANMK03_HUMANHPRD15469820 details