Entity Details

Primary name ACOC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21399
EntryNameACOC_HUMAN
FullNameCytoplasmic aconitate hydratase
TaxID9606
Evidenceevidence at protein level
Length889
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesACO1

GO terms

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GOName
GO:0003723 RNA binding
GO:0003994 aconitate hydratase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
GO:0006417 regulation of translation
GO:0006879 cellular iron ion homeostasis
GO:0009791 post-embryonic development
GO:0010040 response to iron(II) ion
GO:0030350 iron-responsive element binding
GO:0046872 metal ion binding
GO:0047780 citrate dehydratase activity
GO:0050892 intestinal absorption
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domainDomainDomain
IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domainDomainDomain
IPR006249 Aconitase/Iron-responsive element-binding protein 2FamilyFamily
IPR015928 Aconitase/3-isopropylmalate dehydratase, swivelFamilyHomologous superfamily
IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3FamilyHomologous superfamily
IPR018136 Aconitase family, 4Fe-4S cluster binding siteSiteBinding site
IPR029784 Iron regulatory protein 1FamilyFamily
IPR036008 Aconitase, iron-sulfur domainFamilyHomologous superfamily
IPR044137 Aconitase A, swivel domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB06757 ManganeseDrugbanksmall molecule