Entity Details

Primary name CNR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21554
EntryNameCNR1_HUMAN
FullNameCannabinoid receptor 1
TaxID9606
Evidenceevidence at protein level
Length472
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesCNR1

GO terms

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GOName
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004949 cannabinoid receptor activity
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007413 axonal fasciculation
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007613 memory
GO:0010976 positive regulation of neuron projection development
GO:0014063 negative regulation of serotonin secretion
GO:0015629 actin cytoskeleton
GO:0019222 regulation of metabolic process
GO:0019233 sensory perception of pain
GO:0030426 growth cone
GO:0031622 positive regulation of fever generation
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032496 response to lipopolysaccharide
GO:0032592 integral component of mitochondrial membrane
GO:0033004 negative regulation of mast cell activation
GO:0033602 negative regulation of dopamine secretion
GO:0035094 response to nicotine
GO:0038171 cannabinoid signaling pathway
GO:0042220 response to cocaine
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043278 response to morphine
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0045759 negative regulation of action potential
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0050796 regulation of insulin secretion
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060135 maternal process involved in female pregnancy
GO:0060259 regulation of feeding behavior
GO:0060405 regulation of penile erection
GO:0098921 retrograde trans-synaptic signaling by endocannabinoid
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
GO:0099635 voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Membrane raft
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000810 Cannabinoid receptor type 1FamilyFamily
IPR002230 Cannabinoid receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00470 DronabinolDrugbanksmall molecule
DB00486 NabiloneDrugbanksmall molecule
DB02955 Ricinoleic AcidDrugbanksmall molecule
DB05077 SLV319Drugbanksmall molecule
DB05201 V24343Drugbanksmall molecule
DB05750 AVE-1625Drugbanksmall molecule
DB06155 RimonabantDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB11745 OtenabantDrugbanksmall molecule
DB11755 TetrahydrocannabivarinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule