Entity Details

Primary name ACES_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22303
EntryNameACES_HUMAN
FullNameAcetylcholinesterase
TaxID9606
Evidenceevidence at protein level
Length614
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesACHE

GO terms

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GOName
GO:0001507 acetylcholine catabolic process in synaptic cleft
GO:0001540 amyloid-beta binding
GO:0001919 regulation of receptor recycling
GO:0002076 osteoblast development
GO:0003990 acetylcholinesterase activity
GO:0004104 cholinesterase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006581 acetylcholine catabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0007155 cell adhesion
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0009986 cell surface
GO:0016020 membrane
GO:0016787 hydrolase activity
GO:0017171 serine hydrolase activity
GO:0031225 anchored component of membrane
GO:0031594 neuromuscular junction
GO:0031623 receptor internalization
GO:0032223 negative regulation of synaptic transmission, cholinergic
GO:0042136 neurotransmitter biosynthetic process
GO:0042166 acetylcholine binding
GO:0042803 protein homodimerization activity
GO:0042982 amyloid precursor protein metabolic process
GO:0043083 synaptic cleft
GO:0043236 laminin binding
GO:0043621 protein self-association
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0050714 positive regulation of protein secretion
GO:0052689 carboxylic ester hydrolase activity
GO:0060041 retina development in camera-type eye
GO:0095500 acetylcholine receptor signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000997 CholinesteraseFamilyFamily
IPR002018 Carboxylesterase, type BDomainDomain
IPR014788 Acetylcholinesterase, tetramerisation domainDomainDomain
IPR019819 Carboxylesterase type B, conserved siteSiteConserved site
IPR019826 Carboxylesterase type B, active siteSiteActive site
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00122 CholineDrugbanksmall molecule
DB00358 MefloquineDrugbanksmall molecule
DB00382 TacrineDrugbanksmall molecule
DB00411 CarbamoylcholineDrugbanksmall molecule
DB00449 DipivefrinDrugbanksmall molecule
DB00483 Gallamine triethiodideDrugbanksmall molecule
DB00545 PyridostigmineDrugbanksmall molecule
DB00674 GalantamineDrugbanksmall molecule
DB00677 IsoflurophateDrugbanksmall molecule
DB00733 PralidoximeDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00863 RanitidineDrugbanksmall molecule
DB00940 MethanthelineDrugbanksmall molecule
DB00944 DemecariumDrugbanksmall molecule
DB00981 PhysostigmineDrugbanksmall molecule
DB00989 RivastigmineDrugbanksmall molecule
DB01010 EdrophoniumDrugbanksmall molecule
DB01122 AmbenoniumDrugbanksmall molecule
DB01199 TubocurarineDrugbanksmall molecule
DB01245 DecamethoniumDrugbanksmall molecule
DB01364 EphedrineDrugbanksmall molecule
DB01400 NeostigmineDrugbanksmall molecule
DB01805 MonoisopropylphosphorylserineDrugbanksmall molecule
DB02166 PropidiumDrugbanksmall molecule
DB02226 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-PhenanthridiniumDrugbanksmall molecule
DB02343 3,6,9,12,15-PentaoxaheptadecaneDrugbanksmall molecule
DB02404 1-Deoxy-1-Thio-Heptaethylene GlycolDrugbanksmall molecule
DB02673 (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-iumDrugbanksmall molecule
DB02825 MethylphosphinateDrugbanksmall molecule
DB02845 Methylphosphinic AcidDrugbanksmall molecule
DB03005 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-PhenanthridiniumDrugbanksmall molecule
DB03128 AcetylcholineDrugbanksmall molecule
DB03283 beta-L-fucoseDrugbanksmall molecule
DB03348 Huperzine BDrugbanksmall molecule
DB03359 M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-DihydroxyethylbenzeneDrugbanksmall molecule
DB03740 N-acetyl-alpha-D-glucosamineDrugbanksmall molecule
DB03814 2-(N-morpholino)ethanesulfonic acidDrugbanksmall molecule
DB04021 MF268Drugbanksmall molecule
DB04114 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-AmineDrugbanksmall molecule
DB04556 NAP-226-90Drugbanksmall molecule
DB04614 (R)-tacrine(10)-hupyridoneDrugbanksmall molecule
DB04615 (S)-tacrine(10)-hupyridoneDrugbanksmall molecule
DB04616 TACRINE(8)-4-AMINOQUINOLINEDrugbanksmall molecule
DB04617 (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUMDrugbanksmall molecule
DB04859 ZanapezilDrugbanksmall molecule
DB04864 Huperzine ADrugbanksmall molecule
DB04892 PhenserineDrugbanksmall molecule
DB04924 ItoprideDrugbanksmall molecule
DB06525 GanstigmineDrugbanksmall molecule
DB07555 Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammoniumDrugbanksmall molecule
DB07701 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINEDrugbanksmall molecule
DB07756 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOLDrugbanksmall molecule
DB07846 (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamateDrugbanksmall molecule
DB08167 MethylthioniniumDrugbanksmall molecule
DB08357 Diethylene glycol diethyl etherDrugbanksmall molecule
DB08615 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUMDrugbanksmall molecule
DB08996 DimetacrineDrugbanksmall molecule
DB13503 TyrothricinDrugbanksmall molecule
DB14006 Choline salicylateDrugbanksmall molecule