Entity Details

Primary name LSHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22888
EntryNameLSHR_HUMAN
FullNameLutropin-choriogonadotropic hormone receptor
TaxID9606
Evidenceevidence at protein level
Length699
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-04-07

Ontological Relatives

GenesLHCGR

GO terms

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GOName
GO:0001541 ovarian follicle development
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004964 luteinizing hormone receptor activity
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0008528 G protein-coupled peptide receptor activity
GO:0008584 male gonad development
GO:0009755 hormone-mediated signaling pathway
GO:0022602 ovulation cycle process
GO:0030539 male genitalia development
GO:0032962 positive regulation of inositol trisphosphate biosynthetic process
GO:0035472 choriogonadotropin hormone receptor activity
GO:0038106 choriogonadotropin hormone binding
GO:0042700 luteinizing hormone signaling pathway
GO:0050890 cognition
GO:0071371 cellular response to gonadotropin stimulus
GO:0071373 cellular response to luteinizing hormone stimulus

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR002131 Glycoprotein hormone receptor familyFamilyFamily
IPR002273 Lutropin-choriogonadotropic hormone receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain
IPR026906 BspA type Leucine rich repeat regionRepeatRepeat
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
238320 OMIMLuteinizing hormone resistance (LHR)An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. The disease is caused by variants affecting the gene represented in this entry.
176410 OMIMFamilial male precocious puberty (FMPP)In FMPP the receptor is constitutively activated. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00014 GoserelinDrugbanksmall molecule
DB00032 MenotropinsDrugbankbiotech
DB00044 Lutropin alfaDrugbankbiotech
DB00050 CetrorelixDrugbanksmall molecule
DB00097 Choriogonadotropin alfaDrugbankbiotech
DB06719 BuserelinDrugbankbiotech
DB09126 Chorionic Gonadotropin (Human)Drugbankbiotech