Entity Details

Primary name SYWC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23381
EntryNameSYWC_HUMAN
FullNameTryptophan--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length471
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesWARS1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
GO:0006469 negative regulation of protein kinase activity
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010835 regulation of protein ADP-ribosylation
GO:0019210 kinase inhibitor activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032991 protein-containing complex
GO:0042803 protein homodimerization activity
GO:0045765 regulation of angiogenesis
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR002305 Aminoacyl-tRNA synthetase, class IcFamilyFamily
IPR002306 Tryptophan-tRNA ligaseFamilyFamily
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00150 TryptophanDrugbanksmall molecule
DB01831 Tryptophanyl-5'ampDrugbanksmall molecule
DB04537 TryptophanamideDrugbanksmall molecule