Entity Details

Primary name RIR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23921
EntryNameRIR1_HUMAN
FullNameRibonucleoside-diphosphate reductase large subunit
TaxID9606
Evidenceevidence at protein level
Length792
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesRRM1

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 ATP binding
GO:0005635 nuclear envelope
GO:0005829 cytosol
GO:0005971 ribonucleoside-diphosphate reductase complex
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006260 DNA replication
GO:0008584 male gonad development
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0010212 response to ionizing radiation
GO:0015949 nucleobase-containing small molecule interconversion
GO:0021846 cell proliferation in forebrain
GO:0042802 identical protein binding
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0051290 protein heterotetramerization
GO:0060041 retina development in camera-type eye
GO:0061731 ribonucleoside-diphosphate reductase activity
GO:0097718 disordered domain specific binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000788 Ribonucleotide reductase large subunit, C-terminalDomainDomain
IPR005144 ATP-cone domainDomainDomain
IPR008926 Ribonucleotide reductase R1 subunit, N-terminalFamilyHomologous superfamily
IPR013346 Ribonucleotide reductase, class I , alpha subunitDomainDomain
IPR013509 Ribonucleotide reductase large subunit, N-terminalDomainDomain
IPR039718 Ribonucleoside-diphosphate reductase large subunitFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00242 CladribineDrugbanksmall molecule
DB00441 GemcitabineDrugbanksmall molecule
DB00631 ClofarabineDrugbanksmall molecule
DB01005 HydroxyureaDrugbanksmall molecule
DB01073 FludarabineDrugbanksmall molecule
DB05003 ImexonDrugbanksmall molecule
DB05420 Gallium maltolateDrugbanksmall molecule
DB06433 TezacitabineDrugbanksmall molecule