Entity Details

Primary name THIL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24752
EntryNameTHIL_HUMAN
FullNameAcetyl-CoA acetyltransferase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesACAT1

GO terms

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GOName
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006085 acetyl-CoA biosynthetic process
GO:0006550 isoleucine catabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009083 branched-chain amino acid catabolic process
GO:0015936 coenzyme A metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016453 C-acetyltransferase activity
GO:0030955 potassium ion binding
GO:0034435 cholesterol esterification
GO:0046356 acetyl-CoA catabolic process
GO:0046951 ketone body biosynthetic process
GO:0046952 ketone body catabolic process
GO:0070062 extracellular exosome
GO:1902224 ketone body metabolic process
GO:1902860 propionyl-CoA biosynthetic process

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR002155 ThiolaseFamilyFamily
IPR016039 Thiolase-likeFamilyHomologous superfamily
IPR020610 Thiolase, active siteSiteActive site
IPR020613 Thiolase, conserved siteSiteConserved site
IPR020615 Thiolase, acyl-enzyme intermediate active siteSiteActive site
IPR020616 Thiolase, N-terminalDomainDomain
IPR020617 Thiolase, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00795 SulfasalazineDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule