Entity Details

Primary name EPHA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29317
EntryNameEPHA2_HUMAN
FullNameEphrin type-A receptor 2
TaxID9606
Evidenceevidence at protein level
Length976
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA2

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001570 vasculogenesis
GO:0001618 virus receptor activity
GO:0001649 osteoblast differentiation
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009986 cell surface
GO:0010591 regulation of lamellipodium assembly
GO:0014028 notochord formation
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0019838 growth factor binding
GO:0021915 neural tube development
GO:0030027 lamellipodium
GO:0030216 keratinocyte differentiation
GO:0030316 osteoclast differentiation
GO:0031256 leading edge membrane
GO:0031258 lamellipodium membrane
GO:0032587 ruffle membrane
GO:0032682 negative regulation of chemokine production
GO:0033598 mammary gland epithelial cell proliferation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0036342 post-anal tail morphogenesis
GO:0043005 neuron projection
GO:0043235 receptor complex
GO:0043491 protein kinase B signaling
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0045296 cadherin binding
GO:0045765 regulation of angiogenesis
GO:0046058 cAMP metabolic process
GO:0046849 bone remodeling
GO:0048013 ephrin receptor signaling pathway
GO:0048320 axial mesoderm formation
GO:0048870 cell motility
GO:0050830 defense response to Gram-positive bacterium
GO:0051898 negative regulation of protein kinase B signaling
GO:0060035 notochord cell development
GO:0060326 cell chemotaxis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0070160 tight junction
GO:0070309 lens fiber cell morphogenesis
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070848 response to growth factor
GO:0072659 protein localization to plasma membrane
GO:0090630 activation of GTPase activity
GO:1901491 negative regulation of lymphangiogenesis
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903348 positive regulation of bicellular tight junction assembly
GO:1904238 pericyte cell differentiation

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034263 Ephrin type-A receptor 2, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

110 interactions

InteractorPartnerSourcesPublicationsLink
EPHA2_HUMANEPHA2_HUMANBioGRID, HPRD, MINT17192257 18797457 19525919 28065597 28205554 7890684 7982920 details
EPHA2_HUMANEFNA1_HUMANDIP, HPRD, IntAct, MINT14692877 19525919 19573808 20505120 22244754 7973638 8755474 details
EPHA2_HUMANPTN11_HUMANBioGRID, HPRD, MINT, UniProt10655584 28065597 details
EPHA2_HUMANARBK1_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANCDK17_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANIMA4_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANPSME2_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANNUDT9_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANGATD1_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANRBL1_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANLSM7_HUMANBioGRID, IntAct21988832 details
EPHA2_HUMANEPHA7_HUMANIntAct22036564 details
EPHA2_HUMANEFNA5_HUMANDIP, HPRD20228801 20505120 9245480 details
EPHA2_HUMANSHIP2_HUMANDIP22244754 details
EPHA2_HUMANDUS18_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANPTN7_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANILKAP_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANPPM1L_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANPPM1A_HUMANMINT28065597 details
EPHA2_HUMANDUS14_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANDUS19_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANDUS26_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANDUS29_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANSTYX_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANTPTE_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANTPTE2_HUMANBioGRID, MINT28065597 details
EPHA2_HUMANSLAP1_HUMANBioGRID, HPRD24457997 7543898 details
EPHA2_HUMANSHC1_HUMANBioGRID, HPRD12400011 details
EPHA2_HUMANGRB2_HUMANBioGRID, HPRD12400011 details
EPHA2_HUMANP85A_HUMANBioGRID7982920 details
EPHA2_HUMANPPAC_HUMANBioGRID, HPRD12167657 details
EPHA2_HUMANA4_HUMANBioGRID21832049 details
EPHA2_HUMANUBE4A_HUMANBioGRID24457997 details
EPHA2_HUMANERBB2_HUMANBioGRID28205554 30898150 details
EPHA2_HUMANABCB5_HUMANBioGRID28205554 details
EPHA2_HUMANARAF_HUMANBioGRID28205554 details
EPHA2_HUMANARNT_HUMANBioGRID28205554 details
EPHA2_HUMANAURKA_HUMANBioGRID28205554 details
EPHA2_HUMANBECN1_HUMANBioGRID28205554 details
EPHA2_HUMANCBLC_HUMANBioGRID28205554 details
EPHA2_HUMANCCND2_HUMANBioGRID28205554 details
EPHA2_HUMANCDK4_HUMANBioGRID28205554 details
EPHA2_HUMANCDK6_HUMANBioGRID28205554 details
EPHA2_HUMANCDN2A_HUMANBioGRID28205554 details
EPHA2_HUMANARF_HUMANBioGRID28205554 details
EPHA2_HUMANAKT1_HUMANBioGRID28205554 details
EPHA2_HUMANCDN2B_HUMANBioGRID28205554 details
EPHA2_HUMANMP2K3_HUMANBioGRID28205554 28628118 details
EPHA2_HUMANFGFR4_HUMANBioGRID28205554 details
EPHA2_HUMANFZR1_HUMANBioGRID28205554 details
EPHA2_HUMANGLIS2_HUMANBioGRID28205554 details
EPHA2_HUMANGRM1_HUMANBioGRID28205554 details
EPHA2_HUMANHGF_HUMANBioGRID28205554 details
EPHA2_HUMANERD22_HUMANBioGRID28205554 details
EPHA2_HUMANLATS2_HUMANBioGRID28205554 details
EPHA2_HUMANMP2K5_HUMANBioGRID28205554 details
EPHA2_HUMANMET_HUMANBioGRID28205554 details
EPHA2_HUMANMERL_HUMANBioGRID28205554 details
EPHA2_HUMANPGFRA_HUMANBioGRID28205554 details
EPHA2_HUMANTF65_HUMANBioGRID28205554 details
EPHA2_HUMANTEAD2_HUMANBioGRID28205554 details
EPHA2_HUMANP53_HUMANBioGRID28205554 details
EPHA2_HUMANCD44_HUMANBioGRID28205554 details
EPHA2_HUMANCDC42_HUMANBioGRID28205554 details
EPHA2_HUMANCDN2C_HUMANBioGRID28205554 details
EPHA2_HUMANHIF1A_HUMANBioGRID28205554 details
EPHA2_HUMANMP2K6_HUMANBioGRID28205554 details
EPHA2_HUMANMK14_HUMANBioGRID28205554 details
EPHA2_HUMANMDM4_HUMANBioGRID28205554 details
EPHA2_HUMANMSH2_HUMANBioGRID28205554 details
EPHA2_HUMANMYC_HUMANBioGRID28205554 details
EPHA2_HUMANNF1_HUMANBioGRID28205554 details
EPHA2_HUMANNFIC_HUMANBioGRID28205554 details
EPHA2_HUMANPTEN_HUMANBioGRID28205554 details
EPHA2_HUMANRAF1_HUMANBioGRID28205554 details
EPHA2_HUMANRASF1_HUMANBioGRID28205554 details
EPHA2_HUMANSTK11_HUMANBioGRID28205554 details
EPHA2_HUMANANXA1_HUMANBioGRID32737118 details
EPHA2_HUMANP85B_HUMANHPRD7982920 details
EPHA2_HUMANFAK1_HUMANBioGRID, UniProt10655584 details
EPHA2_HUMANHS90B_HUMANIntAct22939624 details
EPHA2_HUMANCTNB1_HUMANBioGRID, DIP18948590 34079125 details
EPHA2_HUMANCBL_HUMANBioGRID, HPRD12147253 12496371 22509030 23874206 32737118 details
EPHA2_HUMANHS90A_HUMANBioGRID22939624 details
EPHA2_HUMANITA3_HUMANBioGRID23874206 details
EPHA2_HUMANITB1_HUMANBioGRID23874206 details
EPHA2_HUMANITB3_HUMANBioGRID23874206 details
EPHA2_HUMANITB5_HUMANBioGRID23874206 details
EPHA2_HUMANITAV_HUMANBioGRID23874206 details
EPHA2_HUMANCLH1_HUMANBioGRID23874206 details
EPHA2_HUMANAP2M1_HUMANBioGRID23874206 details
EPHA2_HUMANAP2B1_HUMANBioGRID23874206 details
EPHA2_HUMANAP2A1_HUMANBioGRID23874206 details
EPHA2_HUMANAP2S1_HUMANBioGRID23874206 details
EPHA2_HUMANEPS15_HUMANBioGRID23874206 details
EPHA2_HUMANTS101_HUMANBioGRID27764233 details
EPHA2_HUMANOPCM_HUMANBioGRID22585860 details
EPHA2_HUMANSOCS2_HUMANBioGRID28883622 details
EPHA2_HUMANSOCS6_HUMANBioGRID28883622 details
EPHA2_HUMANCUL5_HUMANBioGRID28883622 details
EPHA2_HUMANARRD3_HUMANBioGRID29416926 details
EPHA2_HUMANBACD2_HUMANHPRD7536959 details
EPHA2_HUMANTIAM1_HUMANHPRD14988728 details
EPHA2_HUMANEFNA4_HUMANHPRD10607706 8755474 details
EPHA2_HUMANEFNA3_HUMANHPRD12907451 details
EPHA2_HUMANEFNA2_HUMANHPRD8755474 details
EPHA2_HUMANRASA1_HUMANHPRD16051609 details
EPHA2_HUMANCADH5_HUMANHPRD16481735 details
EPHA2_HUMANCLD4_HUMANHPRD16236711 details