Entity Details

Primary name IL12B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29460
EntryNameIL12B_HUMAN
FullNameInterleukin-12 subunit beta
TaxID9606
Evidenceevidence at protein level
Length328
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesIL12B

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002323 natural killer cell activation involved in immune response
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004896 cytokine receptor activity
GO:0005125 cytokine activity
GO:0005143 interleukin-12 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0008283 cell population proliferation
GO:0009897 external side of plasma membrane
GO:0010224 response to UV-B
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0019953 sexual reproduction
GO:0019955 cytokine binding
GO:0030101 natural killer cell activation
GO:0031906 late endosome lumen
GO:0032693 negative regulation of interleukin-10 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0034105 positive regulation of tissue remodeling
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042088 T-helper 1 type immune response
GO:0042093 T-helper cell differentiation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042164 interleukin-12 alpha subunit binding
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043235 receptor complex
GO:0043382 positive regulation of memory T cell differentiation
GO:0043514 interleukin-12 complex
GO:0044877 protein-containing complex binding
GO:0045672 positive regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0046982 protein heterodimerization activity
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050709 negative regulation of protein secretion
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0051142 positive regulation of NK T cell proliferation
GO:0051607 defense response to virus
GO:0070743 interleukin-23 complex
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000330 positive regulation of T-helper 17 cell lineage commitment

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015528 Interleukin-12 betaFamilyFamily
IPR019482 Interleukin-12 beta, central domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02763 5-Mercapto-2-Nitro-Benzoic AcidDrugbanksmall molecule
DB05459 BriakinumabDrugbankbiotech
DB05679 UstekinumabDrugbankbiotech
DB05848 humanized SMART Anti-IL-12 AntibodyDrugbankbiotech
DB06083 TapinarofDrugbanksmall molecule
DB14004 TildrakizumabDrugbankbiotech
DB14762 RisankizumabDrugbankbiotech