Entity Details

Primary name KPYR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30613
EntryNameKPYR_HUMAN
FullNamePyruvate kinase PKLR
TaxID9606
Evidenceevidence at protein level
Length574
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPKLR

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001666 response to hypoxia
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0007584 response to nutrient
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0010226 response to lithium ion
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0032869 cellular response to insulin stimulus
GO:0033198 response to ATP
GO:0042866 pyruvate biosynthetic process
GO:0051591 response to cAMP
GO:0061621 canonical glycolysis
GO:0070062 extracellular exosome
GO:0071872 cellular response to epinephrine stimulus

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001697 Pyruvate kinaseFamilyFamily
IPR011037 Pyruvate kinase-like, insert domain superfamilyFamilyHomologous superfamily
IPR015793 Pyruvate kinase, barrelDomainDomain
IPR015795 Pyruvate kinase, C-terminalDomainDomain
IPR015806 Pyruvate kinase, insert domain superfamilyFamilyHomologous superfamily
IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamilyFamilyHomologous superfamily
IPR018209 Pyruvate kinase, active siteSiteActive site
IPR036918 Pyruvate kinase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR040442 Pyruvate kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00119 Pyruvic acidDrugbanksmall molecule
DB00787 AcyclovirDrugbanksmall molecule
DB02726 2-Phosphoglycolic AcidDrugbanksmall molecule
DB04551 beta-D-fructofuranose 1,6-bisphosphateDrugbanksmall molecule