Entity Details

Primary name RIR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31350
EntryNameRIR2_HUMAN
FullNameRibonucleoside-diphosphate reductase subunit M2
TaxID9606
Evidenceevidence at protein level
Length389
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesRRM2

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0046872 metal ion binding
GO:0070317 negative regulation of G0 to G1 transition

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000358 Ribonucleotide reductase small subunit familyFamilyFamily
IPR009078 Ferritin-like superfamilyFamilyHomologous superfamily
IPR012348 Ribonucleotide reductase-likeFamilyHomologous superfamily
IPR030475 Ribonucleotide reductase small subunit, acitve siteSiteActive site
IPR033909 Ribonucleotide reductase small subunitFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00242 CladribineDrugbanksmall molecule
DB05003 ImexonDrugbanksmall molecule
DB05260 Gallium nitrateDrugbanksmall molecule
DB05428 Motexafin gadoliniumDrugbanksmall molecule
DB05801 GTI 2040Drugbanksmall molecule