Entity Details

Primary name RFC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35250
EntryNameRFC2_HUMAN
FullNameReplication factor C subunit 2
TaxID9606
Evidenceevidence at protein level
Length354
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesRFC2

GO terms

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GOName
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0019985 translesion synthesis
GO:0031390 Ctf18 RFC-like complex
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032508 DNA duplex unwinding
GO:0033683 nucleotide-excision repair, DNA incision
GO:0042276 error-prone translesion synthesis
GO:0042769 DNA damage response, detection of DNA damage
GO:0070987 error-free translesion synthesis
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminalFamilyHomologous superfamily
IPR013748 Replication factor C, C-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

24 interactions

InteractorPartnerSourcesPublicationsLink
RFC2_HUMANRFC4_HUMANBioGRID, HPRD, IntAct, UniProt15655353 16582606 22939629 24981860 26344197 28514442 8692848 9092549 9228079 9488738 9751713 details
RFC2_HUMANRFC5_HUMANBioGRID, HPRD, IntAct22939629 24981860 26344197 28514442 8692848 9228079 9488738 9751713 details
RFC2_HUMANPCNA_HUMANBioGRID, HPRD, IntAct12171929 24958773 26496610 8093561 9228079 details
RFC2_HUMANHGS_HUMANBioGRID, IntAct32296183 details
RFC2_HUMANZIC1_HUMANBioGRID, IntAct32296183 details
RFC2_HUMANOTU1_HUMANBioGRID, IntAct32296183 details
RFC2_HUMANPSA1_HUMANBioGRID, IntAct32296183 details
RFC2_HUMANRAD17_HUMANBioGRID, DIP, IntAct14605214 14624239 28514442 details
RFC2_HUMANBRD4_HUMANBioGRID, MINT12192049 24981860 32416067 details
RFC2_HUMANCTF18_HUMANBioGRID12930902 22939629 details
RFC2_HUMANRAD18_HUMANBioGRID18245774 details
RFC2_HUMANSUMO2_HUMANBioGRID32786267 details
RFC2_HUMANKAP0_HUMANBioGRID, HPRD, UniProt15096576 15655353 16582606 details
RFC2_HUMANRFC1_HUMANBioGRID, HPRD, IntAct, UniProt15655353 18245774 22939629 26344197 9488738 details
RFC2_HUMANPHLA3_HUMANIntAct17353931 details
RFC2_HUMANPITX2_HUMANIntAct20195357 details
RFC2_HUMANPMS2_HUMANBioGRID17148452 details
RFC2_HUMANPMS1_HUMANBioGRID17148452 details
RFC2_HUMANCHD1L_HUMANBioGRID19661379 details
RFC2_HUMANDDX11_HUMANBioGRID18499658 details
RFC2_HUMANSMRCD_HUMANBioGRID21549307 details
RFC2_HUMANRFA1_HUMANBioGRID24332808 24981860 26474068 details
RFC2_HUMANMCM9_HUMANBioGRID26300262 26870752 details
RFC2_HUMANTRI29_HUMANBioGRID26095369 details