Entity Details

Primary name GPX4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36969
EntryNameGPX4_HUMAN
FullNamePhospholipid hydroperoxide glutathione peroxidase
TaxID9606
Evidenceevidence at protein level
Length197
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesGPX4

GO terms

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GOName
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006644 phospholipid metabolic process
GO:0006979 response to oxidative stress
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0032991 protein-containing complex
GO:0042759 long-chain fatty acid biosynthetic process
GO:0042802 identical protein binding
GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity
GO:0051258 protein polymerization
GO:0070062 extracellular exosome
GO:0110076 negative regulation of ferroptosis

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR000889 Glutathione peroxidaseFamilyFamily
IPR029759 Glutathione peroxidase active siteSiteActive site
IPR029760 Glutathione peroxidase conserved siteSiteConserved site
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB03310 Glutathione disulfideDrugbanksmall molecule

Interactions

5 interactions