Entity Details

Primary name CASR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41180
EntryNameCASR_HUMAN
FullNameExtracellular calcium-sensing receptor
TaxID9606
Evidenceevidence at protein level
Length1078
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesCASR

GO terms

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GOName
GO:0001503 ossification
GO:0002931 response to ischemia
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004930 G protein-coupled receptor activity
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005513 detection of calcium ion
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006915 apoptotic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007254 JNK cascade
GO:0007635 chemosensory behavior
GO:0008284 positive regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016597 amino acid binding
GO:0019901 protein kinase binding
GO:0032024 positive regulation of insulin secretion
GO:0032781 positive regulation of ATPase activity
GO:0032782 bile acid secretion
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042311 vasodilation
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043679 axon terminus
GO:0044325 transmembrane transporter binding
GO:0045907 positive regulation of vasoconstriction
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050927 positive regulation of positive chemotaxis
GO:0051924 regulation of calcium ion transport
GO:0060613 fat pad development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070509 calcium ion import
GO:0071305 cellular response to vitamin D
GO:0071333 cellular response to glucose stimulus
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071456 cellular response to hypoxia
GO:0071774 response to fibroblast growth factor
GO:0090280 positive regulation of calcium ion import
GO:1901653 cellular response to peptide
GO:1902476 chloride transmembrane transport

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-relatedFamilyFamily
IPR000337 GPCR, family 3FamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR011500 GPCR, family 3, nine cysteines domainDomainDomain
IPR017978 GPCR family 3, C-terminalDomainDomain
IPR017979 GPCR, family 3, conserved siteSiteConserved site
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR038550 GPCR, family 3, nine cysteines domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00127 SpermineDrugbanksmall molecule
DB00994 NeomycinDrugbanksmall molecule
DB01012 CinacalcetDrugbanksmall molecule
DB05255 RonacaleretDrugbanksmall molecule
DB05695 NPS-2143Drugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB12865 EtelcalcetideDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule