Entity Details

Primary name HNF4A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41235
EntryNameHNF4A_HUMAN
FullNameHepatocyte nuclear factor 4-alpha
TaxID9606
Evidenceevidence at protein level
Length474
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesHNF4A

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003323 type B pancreatic cell development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005102 signaling receptor binding
GO:0005504 fatty acid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006591 ornithine metabolic process
GO:0006629 lipid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007548 sex differentiation
GO:0007596 blood coagulation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009749 response to glucose
GO:0010470 regulation of gastrulation
GO:0019216 regulation of lipid metabolic process
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0048856 anatomical structure development
GO:0050796 regulation of insulin secretion
GO:0055088 lipid homeostasis
GO:0055091 phospholipid homeostasis
GO:0060395 SMAD protein signal transduction
GO:0060398 regulation of growth hormone receptor signaling pathway
GO:0070328 triglyceride homeostasis
GO:0070365 hepatocyte differentiation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR039067 Hepatocyte nuclear factor 4-alphaFamilyFamily

Diseases

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Disease IDSourceNameDescription
125850 OMIMMaturity-onset diabetes of the young 1 (MODY1)A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. The disease is caused by variants affecting the gene represented in this entry.
616026 OMIMFanconi renotubular syndrome 4 with maturity-onset diabetes of the young (FRTS4)An autosomal dominant disease characterized by Fanconi syndrome associated with a beta cell phenotype of neonatal hyperinsulinism with macrosomia and young onset diabetes. Fanconi syndrome is a proximal tubulopathy resulting in generalized aminoaciduria, low molecular weight proteinuria, glycosuria, hyperphosphaturia and hypouricemia. Some FRTS4 patients have nephrocalcinosis, renal impairment, hypercalciuria with relative hypocalcemia, and hypermagnesemia. The disease is caused by variants affecting the gene represented in this entry.
125853 OMIMDiabetes mellitus, non-insulin-dependent (NIDDM)A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB03017 Lauric acidDrugbanksmall molecule
DB05447 AVI-4557Drugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
HNF4A_HUMANSRBP2_HUMANBioGRID, HPRD, MINT12855700 20926756 details
HNF4A_HUMANCITE2_HUMANMINT17932483 details
HNF4A_HUMANAN32B_HUMANBioGRID, IntAct21988832 details
HNF4A_HUMANCTNB1_HUMANBioGRID, IntAct12944908 25241761 details
HNF4A_HUMANPROX1_HUMANbhf-ucl, BioGRID, HPRD15604093 16488887 details
HNF4A_HUMANNR0B2_HUMANbhf-ucl, BioGRID, HPRD10594021 11535594 15604093 16455805 16488887 20516075 28128295 details
HNF4A_HUMANPRGC1_HUMANBioGRID, HPRD, IntAct15322103 15331348 15744310 15826954 17636037 18552123 19846556 20926756 22009745 22155889 details
HNF4A_HUMANMK08_HUMANIntAct15550563 details
HNF4A_HUMANPLPP2_HUMANBioGRID, IntAct25910212 details
HNF4A_HUMANIF1AY_HUMANBioGRID, IntAct25910212 details
HNF4A_HUMANDMD_HUMANBioGRID, IntAct25910212 details
HNF4A_HUMANP53_HUMANBioGRID, HPRD, IntAct11818510 28514442 details
HNF4A_HUMANPHS_HUMANBioGRID, IntAct20211142 details
HNF4A_HUMANCBP_HUMANBioGRID, HPRD10085149 10882110 18552123 9434765 9792714 details
HNF4A_HUMANZNHI3_HUMANBioGRID, HPRD11916906 details
HNF4A_HUMANNCOA1_HUMANBioGRID, HPRD9812974 details
HNF4A_HUMANNCOA2_HUMANBioGRID, HPRD9812974 details
HNF4A_HUMANPRGC2_HUMANBioGRID, HPRD11733490 details
HNF4A_HUMANNR2C2_HUMANBioGRID, HPRD12522137 details
HNF4A_HUMANMED14_HUMANBioGRID, HPRD12089346 12101254 details
HNF4A_HUMANMED1_HUMANBioGRID, HPRD12089346 12101254 details
HNF4A_HUMANFOXO1_HUMANBioGRID, HPRD12519792 19740748 details
HNF4A_HUMANMED24_HUMANBioGRID12101254 details
HNF4A_HUMANMED17_HUMANBioGRID12101254 details
HNF4A_HUMANMED16_HUMANBioGRID12101254 details
HNF4A_HUMANMED7_HUMANBioGRID12101254 details
HNF4A_HUMANMED21_HUMANBioGRID12101254 details
HNF4A_HUMANMED10_HUMANBioGRID12101254 details
HNF4A_HUMANSP1_HUMANBioGRID, HPRD15651981 19115260 details
HNF4A_HUMANANM1_HUMANBioGRID17052457 details
HNF4A_HUMANNCOA6_HUMANBioGRID, HPRD15604093 18552123 21292004 details
HNF4A_HUMANTGS1_HUMANBioGRID18552123 details
HNF4A_HUMANNR1I3_HUMANBioGRID18552123 details
HNF4A_HUMANNCOR2_HUMANBioGRID12205093 details
HNF4A_HUMANHDAC3_HUMANBioGRID12205093 details
HNF4A_HUMANHDAC4_HUMANBioGRID12205093 details
HNF4A_HUMANXPO1_HUMANBioGRID10882110 details
HNF4A_HUMANSRBP1_HUMANBioGRID17636037 20817729 details
HNF4A_HUMANMK03_HUMANBioGRID20371703 details
HNF4A_HUMANMK01_HUMANBioGRID20371703 details
HNF4A_HUMANHNF4A_HUMANBioGRID, HPRD12110948 15604093 28128295 9795230 details
HNF4A_HUMANUBC9_HUMANBioGRID, HPRD15604093 22505616 details
HNF4A_HUMANNRIP1_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANANF_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANPNRC1_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANCSN5_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANPNRC2_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANSMAD3_HUMANBioGRID, HPRD10995777 details
HNF4A_HUMANSMAD4_HUMANBioGRID, HPRD10995777 details
HNF4A_HUMANTBP_HUMANBioGRID9792714 details
HNF4A_HUMANTAF9_HUMANBioGRID9792714 details
HNF4A_HUMANTAF6_HUMANBioGRID9792714 details
HNF4A_HUMANTF2B_HUMANBioGRID9792714 details
HNF4A_HUMANTF2H1_HUMANBioGRID9792714 details
HNF4A_HUMANTAD2A_HUMANBioGRID9792714 details
HNF4A_HUMANTCP4_HUMANBioGRID, HPRD11741883 9792714 details
HNF4A_HUMANRNF4_HUMANBioGRID22505616 details
HNF4A_HUMANPIAS4_HUMANBioGRID12727872 details
HNF4A_HUMANNR1I2_HUMANBioGRID15331348 16455805 details
HNF4A_HUMANKAPCA_HUMANBioGRID11811951 details
HNF4A_HUMANHIF1A_HUMANBioGRID12097158 14741200 details
HNF4A_HUMANARNT_HUMANBioGRID12097158 details
HNF4A_HUMANISL1_HUMANBioGRID17022998 details
HNF4A_HUMANDDX3X_HUMANBioGRID28128295 details
HNF4A_HUMANNRBF2_HUMANHPRD10786636 details
HNF4A_HUMANMECR_HUMANHPRD9795230 details
HNF4A_HUMANESR1_HUMANHPRD9717844 details
HNF4A_HUMANFOXO6_HUMANMINT23714368 details
HNF4A_HUMANGCR_HUMANIntAct17978169 details
HNF4A_HUMANSFPQ_HUMANIntAct23714182 details
HNF4A_HUMANBMAL1_HUMANIntAct30530698 details
HNF4A_HUMANCRY1_HUMANIntAct30530698 details
HNF4A_HUMANANDR_HUMANBioGRID12944908 details
HNF4A_HUMANMED23_HUMANBioGRID12089346 details
HNF4A_HUMANSIR1_HUMANBioGRID, HPRD15744310 20375098 details
HNF4A_HUMANVDR_HUMANBioGRID20371703 details
HNF4A_HUMANGPS2_HUMANBioGRID17895379 details
HNF4A_HUMANMDM2_HUMANBioGRID22197810 details
HNF4A_HUMANEZH2_HUMANBioGRID25391650 details
HNF4A_HUMANSUZ12_HUMANBioGRID25391650 details
HNF4A_HUMANEED_HUMANBioGRID25391650 details
HNF4A_HUMANBMI1_HUMANBioGRID25391650 details
HNF4A_HUMANTF7L2_HUMANBioGRID22951069 details
HNF4A_HUMANPSD10_HUMANBioGRID30109252 details
HNF4A_HUMANAAPK2_HUMANHPRD12740371 details
HNF4A_HUMANSMAD2_HUMANHPRD11229886 details
HNF4A_HUMANTIF1A_HUMANHPRD9115274 details
HNF4A_HUMANMK14_HUMANHPRD16351573 details
HNF4A_HUMANCOT1_HUMANHPRD10652338 details
HNF4A_HUMANHNF1A_HUMANHPRD9792724 details