Entity Details

Primary name HNF4A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41235
EntryNameHNF4A_HUMAN
FullNameHepatocyte nuclear factor 4-alpha
TaxID9606
Evidenceevidence at protein level
Length474
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesHNF4A

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003323 type B pancreatic cell development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005102 signaling receptor binding
GO:0005504 fatty acid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006591 ornithine metabolic process
GO:0006629 lipid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007548 sex differentiation
GO:0007596 blood coagulation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009749 response to glucose
GO:0010470 regulation of gastrulation
GO:0019216 regulation of lipid metabolic process
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0048856 anatomical structure development
GO:0050796 regulation of insulin secretion
GO:0055088 lipid homeostasis
GO:0055091 phospholipid homeostasis
GO:0060395 SMAD protein signal transduction
GO:0060398 regulation of growth hormone receptor signaling pathway
GO:0070328 triglyceride homeostasis
GO:0070365 hepatocyte differentiation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR039067 Hepatocyte nuclear factor 4-alphaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB03017 Lauric acidDrugbanksmall molecule
DB05447 AVI-4557Drugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
HNF4A_HUMANSRBP2_HUMANBioGRID, HPRD, MINT12855700 20926756 details
HNF4A_HUMANCITE2_HUMANMINT17932483 details
HNF4A_HUMANAN32B_HUMANBioGRID, IntAct21988832 details
HNF4A_HUMANCTNB1_HUMANBioGRID, IntAct12944908 25241761 details
HNF4A_HUMANPROX1_HUMANbhf-ucl, BioGRID, HPRD15604093 16488887 details
HNF4A_HUMANNR0B2_HUMANbhf-ucl, BioGRID, HPRD10594021 11535594 15604093 16455805 16488887 20516075 28128295 details
HNF4A_HUMANPRGC1_HUMANBioGRID, HPRD, IntAct15322103 15331348 15744310 15826954 17636037 18552123 19846556 20926756 22009745 22155889 details
HNF4A_HUMANMK08_HUMANIntAct15550563 details
HNF4A_HUMANPLPP2_HUMANBioGRID, IntAct25910212 details
HNF4A_HUMANIF1AY_HUMANBioGRID, IntAct25910212 details
HNF4A_HUMANDMD_HUMANBioGRID, IntAct25910212 details
HNF4A_HUMANP53_HUMANBioGRID, HPRD, IntAct11818510 28514442 details
HNF4A_HUMANPHS_HUMANBioGRID, IntAct20211142 details
HNF4A_HUMANCBP_HUMANBioGRID, HPRD10085149 10882110 18552123 9434765 9792714 details
HNF4A_HUMANZNHI3_HUMANBioGRID, HPRD11916906 details
HNF4A_HUMANNCOA1_HUMANBioGRID, HPRD9812974 details
HNF4A_HUMANNCOA2_HUMANBioGRID, HPRD9812974 details
HNF4A_HUMANPRGC2_HUMANBioGRID, HPRD11733490 details
HNF4A_HUMANNR2C2_HUMANBioGRID, HPRD12522137 details
HNF4A_HUMANMED14_HUMANBioGRID, HPRD12089346 12101254 details
HNF4A_HUMANMED1_HUMANBioGRID, HPRD12089346 12101254 details
HNF4A_HUMANFOXO1_HUMANBioGRID, HPRD12519792 19740748 details
HNF4A_HUMANMED24_HUMANBioGRID12101254 details
HNF4A_HUMANMED17_HUMANBioGRID12101254 details
HNF4A_HUMANMED16_HUMANBioGRID12101254 details
HNF4A_HUMANMED7_HUMANBioGRID12101254 details
HNF4A_HUMANMED21_HUMANBioGRID12101254 details
HNF4A_HUMANMED10_HUMANBioGRID12101254 details
HNF4A_HUMANSP1_HUMANBioGRID, HPRD15651981 19115260 details
HNF4A_HUMANANM1_HUMANBioGRID17052457 details
HNF4A_HUMANNCOA6_HUMANBioGRID, HPRD15604093 18552123 21292004 details
HNF4A_HUMANTGS1_HUMANBioGRID18552123 details
HNF4A_HUMANNR1I3_HUMANBioGRID18552123 details
HNF4A_HUMANNCOR2_HUMANBioGRID12205093 details
HNF4A_HUMANHDAC3_HUMANBioGRID12205093 details
HNF4A_HUMANHDAC4_HUMANBioGRID12205093 details
HNF4A_HUMANXPO1_HUMANBioGRID10882110 details
HNF4A_HUMANSRBP1_HUMANBioGRID17636037 20817729 details
HNF4A_HUMANMK03_HUMANBioGRID20371703 details
HNF4A_HUMANMK01_HUMANBioGRID20371703 details
HNF4A_HUMANHNF4A_HUMANBioGRID, HPRD12110948 15604093 28128295 9795230 details
HNF4A_HUMANUBC9_HUMANBioGRID, HPRD15604093 22505616 details
HNF4A_HUMANNRIP1_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANANF_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANPNRC1_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANCSN5_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANPNRC2_HUMANBioGRID, HPRD15604093 details
HNF4A_HUMANSMAD3_HUMANBioGRID, HPRD10995777 details
HNF4A_HUMANSMAD4_HUMANBioGRID, HPRD10995777 details
HNF4A_HUMANTBP_HUMANBioGRID9792714 details
HNF4A_HUMANTAF9_HUMANBioGRID9792714 details
HNF4A_HUMANTAF6_HUMANBioGRID9792714 details
HNF4A_HUMANTF2B_HUMANBioGRID9792714 details
HNF4A_HUMANTF2H1_HUMANBioGRID9792714 details
HNF4A_HUMANTAD2A_HUMANBioGRID9792714 details
HNF4A_HUMANTCP4_HUMANBioGRID, HPRD11741883 9792714 details
HNF4A_HUMANRNF4_HUMANBioGRID22505616 details
HNF4A_HUMANPIAS4_HUMANBioGRID12727872 details
HNF4A_HUMANNR1I2_HUMANBioGRID15331348 16455805 details
HNF4A_HUMANKAPCA_HUMANBioGRID11811951 details
HNF4A_HUMANHIF1A_HUMANBioGRID12097158 14741200 details
HNF4A_HUMANARNT_HUMANBioGRID12097158 details
HNF4A_HUMANISL1_HUMANBioGRID17022998 details
HNF4A_HUMANDDX3X_HUMANBioGRID28128295 details
HNF4A_HUMANNRBF2_HUMANHPRD10786636 details
HNF4A_HUMANMECR_HUMANHPRD9795230 details
HNF4A_HUMANESR1_HUMANHPRD9717844 details
HNF4A_HUMANFOXO6_HUMANMINT23714368 details
HNF4A_HUMANGCR_HUMANIntAct17978169 details
HNF4A_HUMANSFPQ_HUMANIntAct23714182 details
HNF4A_HUMANBMAL1_HUMANIntAct30530698 details
HNF4A_HUMANCRY1_HUMANIntAct30530698 details
HNF4A_HUMANANDR_HUMANBioGRID12944908 details
HNF4A_HUMANMED23_HUMANBioGRID12089346 details
HNF4A_HUMANSIR1_HUMANBioGRID, HPRD15744310 20375098 details
HNF4A_HUMANVDR_HUMANBioGRID20371703 details
HNF4A_HUMANGPS2_HUMANBioGRID17895379 details
HNF4A_HUMANMDM2_HUMANBioGRID22197810 details
HNF4A_HUMANEZH2_HUMANBioGRID25391650 details
HNF4A_HUMANSUZ12_HUMANBioGRID25391650 details
HNF4A_HUMANEED_HUMANBioGRID25391650 details
HNF4A_HUMANBMI1_HUMANBioGRID25391650 details
HNF4A_HUMANTF7L2_HUMANBioGRID22951069 details
HNF4A_HUMANPSD10_HUMANBioGRID30109252 details
HNF4A_HUMANAAPK2_HUMANHPRD12740371 details
HNF4A_HUMANSMAD2_HUMANHPRD11229886 details
HNF4A_HUMANTIF1A_HUMANHPRD9115274 details
HNF4A_HUMANMK14_HUMANHPRD16351573 details
HNF4A_HUMANCOT1_HUMANHPRD10652338 details
HNF4A_HUMANHNF1A_HUMANHPRD9792724 details