Entity Details

Primary name I12R1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42701
EntryNameI12R1_HUMAN
FullNameInterleukin-12 receptor subunit beta-1
TaxID9606
Evidenceevidence at protein level
Length662
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesIL12RB1

GO terms

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GOName
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0004896 cytokine receptor activity
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0009897 external side of plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019955 cytokine binding
GO:0032729 positive regulation of interferon-gamma production
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042022 interleukin-12 receptor complex
GO:0042104 positive regulation of activated T cell proliferation
GO:0043235 receptor complex
GO:0043382 positive regulation of memory T cell differentiation
GO:0071346 cellular response to interferon-gamma
GO:0072536 interleukin-23 receptor complex
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000330 positive regulation of T-helper 17 cell lineage commitment

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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