Entity Details

Primary name ECE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42892
EntryNameECE1_HUMAN
FullNameEndothelin-converting enzyme 1
TaxID9606
Evidenceevidence at protein level
Length770
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesECE1

GO terms

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GOName
GO:0001921 positive regulation of receptor recycling
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007507 heart development
GO:0008270 zinc ion binding
GO:0009897 external side of plasma membrane
GO:0010814 substance P catabolic process
GO:0010815 bradykinin catabolic process
GO:0010816 calcitonin catabolic process
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0017046 peptide hormone binding
GO:0019229 regulation of vasoconstriction
GO:0031302 intrinsic component of endosome membrane
GO:0031982 vesicle
GO:0033093 Weibel-Palade body
GO:0034959 endothelin maturation
GO:0042447 hormone catabolic process
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0043583 ear development
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000718 Peptidase M13FamilyFamily
IPR008753 Peptidase M13, N-terminal domainDomainDomain
IPR018497 Peptidase M13, C-terminal domainDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR029734 Endothelin-converting enzyme 1FamilyFamily
IPR042089 Peptidase M13, domain 2FamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07171 5-(2-hydroxyethyl)nonane-1,9-diolDrugbanksmall molecule