Entity Details

Primary name KSYK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43405
EntryNameKSYK_HUMAN
FullNameTyrosine-protein kinase SYK
TaxID9606
Evidenceevidence at protein level
Length635
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesSYK

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001784 phosphotyrosine residue binding
GO:0001945 lymph vessel development
GO:0002092 positive regulation of receptor internalization
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002281 macrophage activation involved in immune response
GO:0002283 neutrophil activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002554 serotonin secretion by platelet
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0007159 leukocyte cell-cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007257 obsolete activation of JUN kinase activity
GO:0009887 animal organ morphogenesis
GO:0010543 regulation of platelet activation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0016170 interleukin-15 receptor binding
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019370 leukotriene biosynthetic process
GO:0019815 B cell receptor complex
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031623 receptor internalization
GO:0032009 early phagosome
GO:0032481 positive regulation of type I interferon production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032752 positive regulation of interleukin-3 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032928 regulation of superoxide anion generation
GO:0032930 positive regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035325 Toll-like receptor binding
GO:0035556 intracellular signal transduction
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038156 interleukin-3-mediated signaling pathway
GO:0042101 T cell receptor complex
GO:0042169 SH2 domain binding
GO:0042742 defense response to bacterium
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043306 positive regulation of mast cell degranulation
GO:0043313 regulation of neutrophil degranulation
GO:0043366 beta selection
GO:0045087 innate immune response
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045780 positive regulation of bone resorption
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046777 protein autophosphorylation
GO:0048514 blood vessel morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050853 B cell receptor signaling pathway
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051712 positive regulation of killing of cells of other organism
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0071226 cellular response to molecule of fungal origin
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0090237 regulation of arachidonic acid secretion
GO:0090330 regulation of platelet aggregation
GO:0097110 scaffold protein binding
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamilyFamilyHomologous superfamily
IPR035838 SYK/ZAP-70, N-terminal SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02010 StaurosporineDrugbanksmall molecule
DB06834 N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamideDrugbanksmall molecule
DB07159 TamatinibDrugbanksmall molecule
DB07194 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamideDrugbanksmall molecule
DB08361 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamideDrugbanksmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

156 interactions

InteractorPartnerSourcesPublicationsLink
KSYK_HUMANCBL_HUMANBioGRID, HPRD, MINT10540342 10570266 10617633 11042121 11133830 11331248 11742985 12435267 15536084 15556646 15577829 16289966 18273061 27614019 31120930 7721825 8621719 9857068 details
KSYK_HUMANLCK_HUMANBioGRID, HPRD, MINT15536084 7539035 8621719 8798676 8798764 details
KSYK_HUMANFCERG_HUMANBioGRID, HPRD, IntAct, MINT8071371 8810294 9280292 details
KSYK_HUMANP85A_HUMANBioGRID, HPRD, MINT15536084 16921024 details
KSYK_HUMANFGR_HUMANBioGRID, HPRD, MINT11672534 15536084 details
KSYK_HUMANP85B_HUMANBioGRID, HPRD, MINT15536084 details
KSYK_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
KSYK_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
KSYK_HUMANEGFR_HUMANBioGRID, MINT16273093 22973453 details
KSYK_HUMANERBB4_HUMANBioGRID, MINT16273093 22973453 details
KSYK_HUMAN3BP2_HUMANBioGRID, HPRD, MINT11390470 12709437 15345594 20439986 9846481 details
KSYK_HUMANVAV2_HUMANBioGRID, HPRD, MINT11262396 15345594 details
KSYK_HUMANTYOBP_HUMANBioGRID, HPRD, IntAct10940905 9490415 9830044 details
KSYK_HUMANFCG2A_HUMANBioGRID, HPRD, MINT11141335 7487883 8756631 9268059 9280292 9295288 details
KSYK_HUMANCD3E_HUMANBioGRID, HPRD, MINT7761456 9698567 details
KSYK_HUMANUBP25_HUMANBioGRID, IntAct, MINT19909739 21516116 25416956 32296183 details
KSYK_HUMANSTAT3_HUMANBioGRID, DIP, HPRD, IntAct, MINT10825200 20133729 21516116 25416956 31515488 32296183 details
KSYK_HUMANUBS3B_HUMANBioGRID, MINT20585042 22267732 details
KSYK_HUMANFLT3_HUMANIntAct, MINT24525236 28086240 details
KSYK_HUMANANDR_HUMANBioGRID, IntAct24728074 details
KSYK_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
KSYK_HUMANKIT_HUMANBioGRID, IntAct24728074 details
KSYK_HUMANMET_HUMANBioGRID, IntAct24728074 details
KSYK_HUMANTET5A_HUMANBioGRID, IntAct25814554 details
KSYK_HUMANSH22A_HUMANBioGRID, IntAct25416956 details
KSYK_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
KSYK_HUMANNLRP3_HUMANIntAct25605870 details
KSYK_HUMANASC_HUMANIntAct25605870 details
KSYK_HUMANKSYK_HUMANBioGRID, HPRD, IntAct11356834 16291755 18070606 25605870 8657103 9698567 9820500 9857068 details
KSYK_HUMANPP1A_HUMANIntAct32814053 details
KSYK_HUMANLRP1_HUMANIntAct32814053 details
KSYK_HUMANHS71A_HUMANIntAct32814053 details
KSYK_HUMANDC1I1_HUMANIntAct32814053 details
KSYK_HUMANCALX_HUMANIntAct32814053 details
KSYK_HUMANBLMH_HUMANIntAct32814053 details
KSYK_HUMANAPLP2_HUMANIntAct32814053 details
KSYK_HUMANA2MG_HUMANIntAct32814053 details
KSYK_HUMANNBL1_HUMANIntAct32814053 details
KSYK_HUMANCPNE8_HUMANIntAct32814053 details
KSYK_HUMANCRCT1_HUMANIntAct32814053 details
KSYK_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct11418661 23962979 25202827 32814053 details
KSYK_HUMANSHC1_HUMANHPRD, IntAct10482988 32814053 9096689 9388490 9710204 details
KSYK_HUMANRAC1_HUMANIntAct32814053 details
KSYK_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
KSYK_HUMANCD79A_HUMANBioGRID, HPRD7500027 details
KSYK_HUMANCD79B_HUMANBioGRID, HPRD12453414 7500027 7538118 details
KSYK_HUMANPTN6_HUMANBioGRID, HPRD10072516 10747947 10871605 11356834 details
KSYK_HUMANLYN_HUMANBioGRID, HPRD11536198 7831290 8621719 9820500 details
KSYK_HUMANCRKL_HUMANBioGRID, HPRD11313252 details
KSYK_HUMANLAT_HUMANBioGRID, HPRD11368773 9891970 details
KSYK_HUMANSRC_HUMANBioGRID, HPRD15173175 7513017 9389695 details
KSYK_HUMANVAV_HUMANBioGRID, HPRD11262396 11331248 8900182 8986718 details
KSYK_HUMANKS6B1_HUMANBioGRID16640565 details
KSYK_HUMANKS6B2_HUMANBioGRID16640565 details
KSYK_HUMANFCERB_HUMANBioGRID, HPRD8071371 details
KSYK_HUMANPHAG1_HUMANBioGRID, HPRD10790433 details
KSYK_HUMANCD72_HUMANBioGRID9590210 details
KSYK_HUMANTBA1A_HUMANBioGRID, HPRD10862713 details
KSYK_HUMANFCRL3_HUMANBioGRID12051764 details
KSYK_HUMANFYN_HUMANBioGRID, HPRD9535867 details
KSYK_HUMANCBLB_HUMANBioGRID, HPRD10022120 12771181 27428901 details
KSYK_HUMANHDAC1_HUMANBioGRID16288017 details
KSYK_HUMANHDAC3_HUMANBioGRID16288017 details
KSYK_HUMANHDAC6_HUMANBioGRID16288017 details
KSYK_HUMANHDAC9_HUMANBioGRID16288017 details
KSYK_HUMANHDAC2_HUMANBioGRID16288017 details
KSYK_HUMANHDAC4_HUMANBioGRID16288017 details
KSYK_HUMANCALM1_HUMANBioGRID3350007 3472906 details
KSYK_HUMANCALM2_HUMANBioGRID3350007 3472906 details
KSYK_HUMANCALM3_HUMANBioGRID3350007 3472906 details
KSYK_HUMANNEDD4_HUMANBioGRID19953087 details
KSYK_HUMANLCP2_HUMANBioGRID, HPRD15388330 22267732 details
KSYK_HUMANRS10_HUMANBioGRID15536084 details
KSYK_HUMANB3AT_HUMANBioGRID, HPRD10605028 10942405 16118313 1998697 2065070 details
KSYK_HUMANTRAIP_HUMANBioGRID19151749 details
KSYK_HUMANTAU_HUMANBioGRID18070606 details
KSYK_HUMANFCG3A_HUMANBioGRID8189062 details
KSYK_HUMANTRI15_HUMANBioGRID25450970 details
KSYK_HUMANRHOU_HUMANBioGRID26598620 details
KSYK_HUMANHGS_HUMANBioGRID22706924 details
KSYK_HUMANDPP9_HUMANBioGRID27614019 details
KSYK_HUMANCOASY_HUMANBioGRID19763791 details
KSYK_HUMANCD22_HUMANBioGRID, HPRD, IntAct8627166 8647200 details
KSYK_HUMANITB2_HUMANBioGRID, HPRD, IntAct10961871 12885943 details
KSYK_HUMANOBF1_HUMANHPRD, IntAct16713566 details
KSYK_HUMANBLNK_HUMANBioGRID, HPRD, MINT10981967 18369315 21482705 21822214 details
KSYK_HUMANMOES_HUMANMINT12387735 details
KSYK_HUMANPLCG1_HUMANBioGRID, HPRD, MINT15144186 1689310 7682059 7831290 8657103 8885868 details
KSYK_HUMANCD37_HUMANIntAct22624718 details
KSYK_HUMANFCGR1_HUMANBioGRID, HPRD, IntAct11141335 25241761 details
KSYK_HUMANHCLS1_HUMANBioGRID, HPRD, IntAct25241761 9104825 details
KSYK_HUMANSRC8_HUMANBioGRID, HPRD, IntAct25241761 8636079 details
KSYK_HUMANGRB2_HUMANBioGRID, HPRD10747947 11964172 22267732 details
KSYK_HUMANFAK2_HUMANBioGRID, HPRD10747947 details
KSYK_HUMANSLAP1_HUMANBioGRID, HPRD10449770 details
KSYK_HUMANKPCD1_HUMANBioGRID, HPRD8885868 details
KSYK_HUMANFAK1_HUMANBioGRID9169439 9342235 details
KSYK_HUMANPAXI_HUMANBioGRID, HPRD9590268 details
KSYK_HUMANPLCG2_HUMANBioGRID, HPRD10933389 10981967 12470302 12771181 details
KSYK_HUMANCD19_HUMANBioGRID, HPRD9120258 details
KSYK_HUMANEPOR_HUMANBioGRID, HPRD9852052 details
KSYK_HUMANSIT1_HUMANBioGRID, HPRD10209036 details
KSYK_HUMANCSF3R_HUMANBioGRID, HPRD8197119 details
KSYK_HUMANCD4_HUMANBioGRID7539035 details
KSYK_HUMANSP1_HUMANBioGRID16288017 details
KSYK_HUMANTBG1_HUMANBioGRID16322234 details
KSYK_HUMANSHIP1_HUMANBioGRID22267732 details
KSYK_HUMANSC23B_HUMANBioGRID22267732 details
KSYK_HUMANNCK1_HUMANBioGRID22267732 details
KSYK_HUMANGRAP2_HUMANBioGRID22267732 details
KSYK_HUMANITB3_HUMANBioGRID11042121 details
KSYK_HUMANFCERA_HUMANBioGRID9103201 details
KSYK_HUMANPK3CG_HUMANBioGRID7721825 details
KSYK_HUMANBTK_HUMANBioGRID, HPRD10427990 11226282 11598012 8629002 8630736 details
KSYK_HUMANTBB5_HUMANBioGRID9880513 details
KSYK_HUMANITA4_HUMANBioGRID22623428 details
KSYK_HUMANTLR3_HUMANBioGRID23962979 details
KSYK_HUMANTLR4_HUMANBioGRID, HPRD14699155 23962979 details
KSYK_HUMANTLR9_HUMANBioGRID23962979 details
KSYK_HUMANTRAF3_HUMANBioGRID23962979 details
KSYK_HUMANTBK1_HUMANBioGRID23962979 details
KSYK_HUMANMYD88_HUMANBioGRID23962979 details
KSYK_HUMANM3K7_HUMANBioGRID23962979 details
KSYK_HUMANTCAM1_HUMANBioGRID23962979 details
KSYK_HUMANPTPRO_HUMANBioGRID23533167 details
KSYK_HUMANI17RA_HUMANBioGRID25202827 details
KSYK_HUMANCIKS_HUMANBioGRID25202827 details
KSYK_HUMANPEAR1_HUMANBioGRID22993420 details
KSYK_HUMANMEG10_HUMANBioGRID22993420 details
KSYK_HUMANTNR1A_HUMANBioGRID, HPRD16291755 26212014 details
KSYK_HUMANGRM1_HUMANBioGRID15173175 details
KSYK_HUMANGRASP_HUMANBioGRID15173175 details
KSYK_HUMANFLNA_HUMANBioGRID27614019 details
KSYK_HUMANBCAP_HUMANBioGRID, HPRD11163197 27909057 details
KSYK_HUMANABCF1_HUMANBioGRID30770245 details
KSYK_HUMANKPCA_HUMANHPRD12881490 details
KSYK_HUMANTBA4A_HUMANHPRD8617742 details
KSYK_HUMANSTA5A_HUMANHPRD10825200 details
KSYK_HUMANM4K1_HUMANHPRD11514608 details
KSYK_HUMANHNRPU_HUMANHPRD7831290 details
KSYK_HUMANGAB2_HUMANHPRD11895767 details
KSYK_HUMANSH2B2_HUMANHPRD10872802 details
KSYK_HUMANNFAM1_HUMANHPRD15143214 details
KSYK_HUMANDBNL_HUMANHPRD9891087 details
KSYK_HUMANI15RA_HUMANHPRD11714793 details
KSYK_HUMANIL3RB_HUMANHPRD8666899 details
KSYK_HUMANRASA1_HUMANHPRD9218456 details
KSYK_HUMANIL2RB_HUMANHPRD7600304 details
KSYK_HUMANKS6A1_HUMANHPRD9218456 details
KSYK_HUMANMK03_HUMANHPRD9218456 details
KSYK_HUMANLAX1_HUMANHPRD12359715 details
KSYK_HUMANSTAT1_HUMANHPRD15467722 details
KSYK_HUMANUBB_HUMANHPRD11046148 details
KSYK_HUMANDUS3_HUMANHPRD12447358 details
KSYK_HUMANJAK1_HUMANHPRD10825200 details
KSYK_HUMANSYUA_HUMANHPRD11162638 11744621 12096713 details