Entity Details

Primary name MP2K4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP45985
EntryNameMP2K4_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 4
TaxID9606
Evidenceevidence at protein level
Length399
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K4

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0007257 obsolete activation of JUN kinase activity
GO:0008545 JUN kinase kinase activity
GO:0009611 response to wounding
GO:0030424 axon
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032839 dendrite cytoplasm
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043204 perikaryon
GO:0043525 positive regulation of neuron apoptotic process
GO:0045740 positive regulation of DNA replication
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0071260 cellular response to mechanical stimulus
GO:0072709 cellular response to sorbitol
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000672 negative regulation of motor neuron apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
MP2K4_HUMANM3K1_HUMANBioGRID, IntAct10713157 12228228 14500727 14581471 15299005 15866172 16472679 27806347 9808624 details
MP2K4_HUMANMK08_HUMANBioGRID, HPRD, IntAct10713157 11062067 11279118 11707464 12391307 12788955 13130464 15998799 16533805 9162092 9661668 9808624 details
MP2K4_HUMANARRB2_HUMANBioGRID, MINT11090355 19782076 details
MP2K4_HUMANARRB1_HUMANBioGRID, MINT19782076 details
MP2K4_HUMANCTIP_HUMANBioGRID, IntAct21988832 details
MP2K4_HUMANMK09_HUMANBioGRID, HPRD, MINT11062067 12788955 21900206 22366412 details
MP2K4_HUMANALDOB_HUMANBioGRID, MINT24412244 details
MP2K4_HUMANCYLC2_HUMANBioGRID, MINT24412244 details
MP2K4_HUMANF16P2_HUMANBioGRID, MINT24412244 details
MP2K4_HUMANSTX17_HUMANBioGRID, MINT24412244 details
MP2K4_HUMANFLNC_HUMANBioGRID, HPRD9006895 details
MP2K4_HUMANM4K2_HUMANBioGRID9712898 details
MP2K4_HUMANM3K8_HUMANBioGRID, HPRD8631303 details
MP2K4_HUMANAKT1_HUMANBioGRID, HPRD11707464 15998799 details
MP2K4_HUMANM3K11_HUMANBioGRID10187804 details
MP2K4_HUMANM3K4_HUMANBioGRID, HPRD15866172 9841871 details
MP2K4_HUMANM3K2_HUMANBioGRID, HPRD10713157 17906693 7997270 9162092 details
MP2K4_HUMANITCH_HUMANBioGRID19737936 details
MP2K4_HUMANMK10_HUMANBioGRID, HPRD10715136 12788955 15299005 details
MP2K4_HUMANM3K5_HUMANBioGRID15258908 15299005 15310755 16142216 17541429 details
MP2K4_HUMANMP2K6_HUMANBioGRID15866172 details
MP2K4_HUMANMP2K4_HUMANBioGRID, HPRD14504284 16533805 9162092 details
MP2K4_HUMANMK14_HUMANBioGRID, HPRD7716521 9162092 9808624 details
MP2K4_HUMANM3K3_HUMANBioGRID25043814 9162092 details
MP2K4_HUMANLRRK2_HUMANBioGRID19302196 details
MP2K4_HUMANA4_HUMANBioGRID21832049 details
MP2K4_HUMANJUN_HUMANBioGRID13130464 details
MP2K4_HUMANM3K7_HUMANBioGRID, HPRD12429732 12556533 details
MP2K4_HUMANMK01_HUMANBioGRID12788955 details
MP2K4_HUMANGEMI5_HUMANBioGRID17541429 details
MP2K4_HUMANM3K10_HUMANBioGRID, HPRD9182538 details
MP2K4_HUMANNBR1_HUMANBioGRID25043814 details
MP2K4_HUMANUBC_HUMANBioGRID28190767 details
MP2K4_HUMANTRIB1_HUMANHPRD, IntAct15299019 details
MP2K4_HUMANCFLAR_HUMANHPRD, MINT17110930 details
MP2K4_HUMANJIP4_HUMANBioGRID, HPRD12391307 details
MP2K4_HUMANJIP3_HUMANBioGRID, HPRD10523642 12189133 details
MP2K4_HUMANPML_HUMANBioGRID10620019 details
MP2K4_HUMANMP2K7_HUMANBioGRID13130464 details
MP2K4_HUMANGCH1_HUMANBioGRID19294699 details
MP2K4_HUMANFLNB_HUMANBioGRID19270716 details
MP2K4_HUMANSH3R3_HUMANBioGRID32427938 details
MP2K4_HUMANFLNA_HUMANHPRD9006895 details
MP2K4_HUMANM3K12_HUMANHPRD10187804 details
MP2K4_HUMANEFNA4_HUMANHPRD8755474 details
MP2K4_HUMANMK12_HUMANHPRD11062067 details
MP2K4_HUMANM3K20_HUMANHPRD11836244 details
MP2K4_HUMANDUS22_HUMANHPRD11346645 details
MP2K4_HUMANM3K14_HUMANHPRD10521444 details