Entity Details

Primary name 5HT3A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46098
EntryName5HT3A_HUMAN
FullName5-hydroxytryptamine receptor 3A
TaxID9606
Evidenceevidence at protein level
Length478
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesHTR3A

GO terms

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GOName
GO:0004888 transmembrane signaling receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0022850 serotonin-gated cation-selective channel activity
GO:0030424 axon
GO:0030594 neurotransmitter receptor activity
GO:0032154 cleavage furrow
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0034220 ion transmembrane transport
GO:0042220 response to cocaine
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0045471 response to ethanol
GO:0050877 nervous system process
GO:0051378 serotonin binding
GO:0071363 cellular response to growth factor stimulus
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:1904602 serotonin-activated cation-selective channel complex

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR008132 5-hydroxytryptamine 3 receptorFamilyFamily
IPR008133 5-hydroxytryptamine 3 receptor, A subunitFamilyFamily
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00246 ZiprasidoneDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00377 PalonosetronDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00604 CisaprideDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00721 ProcaineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00728 RocuroniumDrugbanksmall molecule
DB00757 DolasetronDrugbanksmall molecule
DB00889 GranisetronDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00969 AlosetronDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01156 BupropionDrugbanksmall molecule
DB01199 TubocurarineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01233 MetoclopramideDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB04885 CilansetronDrugbanksmall molecule
DB04917 RenzaprideDrugbanksmall molecule
DB05049 DDP733Drugbanksmall molecule
DB05642 DDP-225Drugbanksmall molecule
DB06204 TapentadolDrugbanksmall molecule
DB06422 TicaloprideDrugbanksmall molecule
DB08839 SerotoninDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09290 RamosetronDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB11699 TropisetronDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule