Entity Details

Primary name GSHB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48637
EntryNameGSHB_HUMAN
FullNameGlutathione synthetase
TaxID9606
Evidenceevidence at protein level
Length474
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesGSS

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004363 glutathione synthase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006520 cellular amino acid metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006979 response to oxidative stress
GO:0007399 nervous system development
GO:0007568 aging
GO:0009410 response to xenobiotic stimulus
GO:0016594 glycine binding
GO:0031667 response to nutrient levels
GO:0034612 response to tumor necrosis factor
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043200 response to amino acid
GO:0043295 glutathione binding
GO:0046686 response to cadmium ion
GO:0070062 extracellular exosome

Subcellular Location

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Domains

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DomainNameCategoryType
IPR004887 Glutathione synthase, substrate-binding domainDomainDomain
IPR005615 Glutathione synthaseFamilyFamily
IPR014042 Glutathione synthase, alpha-helicalFamilyHomologous superfamily
IPR014049 Glutathione synthase, N-terminal, eukaryoticFamilyHomologous superfamily
IPR014709 Glutathione synthase, C-terminal, eukaryoticFamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily
IPR037013 Glutathione synthase, substrate-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
266130 OMIMGlutathione synthetase deficiency (GSS deficiency)Severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. The disease is caused by variants affecting the gene represented in this entry.
231900 OMIMGlutathione synthetase deficiency of erythrocytes (GLUSYNDE)Mild form causing hemolytic anemia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule
DB03408 gamma-GlutamylcysteineDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule