Entity Details

Primary name IRAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51617
EntryNameIRAK1_HUMAN
FullNameInterleukin-1 receptor-associated kinase 1
TaxID9606
Evidenceevidence at protein level
Length712
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesIRAK1

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007254 JNK cascade
GO:0007568 aging
GO:0010008 endosome membrane
GO:0016032 viral process
GO:0016301 kinase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0031072 heat shock protein binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034605 cellular response to heat
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071456 cellular response to hypoxia
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell

Subcellular Location

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Subcellular Location
Cytoplasm
Lipid droplet
Nucleus

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR035533 Interleukin-1 receptor-associated kinase 1, death domainDomainDomain
IPR035536 Interleukin-1 receptor-associated kinase 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
IRAK1_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct, MINT10346818 10383454 10920205 11259596 11287640 11397809 11518704 11960013 12242293 12496252 12566447 14625308 16024789 16951688 17197697 17785851 18056395 18234474 18347055 19166926 19716405 20043910 21220427 22033459 22447928 23244239 23381138 24434549 24735611 28882891 30872404 31921110 8837778 9374458 details
IRAK1_HUMANIRAK1_HUMANBioGRID, HPRD, MINT10383454 11259596 11397809 11960013 12138165 14625308 16024789 16951688 18524972 19166926 details
IRAK1_HUMANIRAK2_HUMANBioGRID, HPRD, IntAct, MINT10383454 12138165 21903422 details
IRAK1_HUMANIRAK3_HUMANBioGRID, HPRD, IntAct, MINT10383454 12138165 19166926 21903422 details
IRAK1_HUMANPELI1_HUMANBioGRID, DIP, HPRD, IntAct, MINT12496252 15917247 16884718 16951688 17675297 17997719 19081057 19264966 21204785 26082489 details
IRAK1_HUMANIRAK4_HUMANBioGRID, HPRD, IntAct11960013 12538665 12860405 16024789 16951688 17276401 17785851 18221795 19166926 21903422 24735611 details
IRAK1_HUMANPELI2_HUMANBioGRID, DIP, HPRD, IntAct, MINT12370331 12860405 15917247 16884718 17675297 18326498 19081057 25027698 details
IRAK1_HUMANPIN1_HUMANInnateDB21743479 details
IRAK1_HUMANIRF4_HUMANBioGRID, IntAct21903422 details
IRAK1_HUMANIRF7_HUMANBioGRID, HPRD, IntAct15767370 21903422 details
IRAK1_HUMANSTING_HUMANBioGRID, IntAct21903422 details
IRAK1_HUMANTIRAP_HUMANBioGRID, IntAct21903422 details
IRAK1_HUMANNEMO_HUMANBioGRID, HPRD, InnateDB17997719 18180283 18347055 21220427 23104095 23986494 24735611 details
IRAK1_HUMANTAB2_HUMANBioGRID, DIP, HPRD11518704 12242293 18180283 19675569 23986494 24735611 details
IRAK1_HUMANUN93B_HUMANBioGRID, IntAct21903422 30833792 details
IRAK1_HUMANIKBP1_HUMANBioGRID, HPRD11096118 details
IRAK1_HUMANBCL10_HUMANBioGRID16831874 details
IRAK1_HUMANTRI32_HUMANBioGRID21903422 details
IRAK1_HUMANCCD47_HUMANBioGRID21903422 details
IRAK1_HUMANPP2BB_HUMANBioGRID21903422 details
IRAK1_HUMANYTDC2_HUMANBioGRID21903422 details
IRAK1_HUMANH31T_HUMANBioGRID18276832 details
IRAK1_HUMANOPTN_HUMANBioGRID28882891 details
IRAK1_HUMANTAB1_HUMANIntAct14743216 details
IRAK1_HUMANMYD88_HUMANBioGRID, DIP, HPIDb, HPRD, MINT10383454 10854325 11544529 11960013 11976320 12538665 16024789 16461741 16951688 17276401 17548806 17567694 17920759 21179087 21903422 22011580 31776466 33052227 details
IRAK1_HUMANPELI3_HUMANBioGRID, DIP, HPRD, IntAct, MINT12874243 15917247 16884718 17675297 18326498 19081057 25027698 details
IRAK1_HUMANUBC_HUMANMINT16884718 details
IRAK1_HUMANTOLIP_HUMANBioGRID, HPRD, IntAct10854325 11397809 15388348 16024789 16107720 17113392 17276401 19716405 21903422 23244239 26673132 details
IRAK1_HUMANHSP7C_HUMANBioGRID, IntAct15647277 29568061 details
IRAK1_HUMANSIGIR_HUMANBioGRID, HPRD12925853 details
IRAK1_HUMANAKT1_HUMANBioGRID, HPRD11976320 details
IRAK1_HUMANIL1AP_HUMANBioGRID, HPRD24735611 9371760 details
IRAK1_HUMANKPCZ_HUMANBioGRID, HPRD11937546 details
IRAK1_HUMANSQSTM_HUMANBioGRID, HPRD10747026 12034707 34079125 details
IRAK1_HUMANIKKB_HUMANBioGRID11096118 18180283 details
IRAK1_HUMANIKKA_HUMANBioGRID11096118 18180283 details
IRAK1_HUMANTLR2_HUMANBioGRID, HPRD10395652 details
IRAK1_HUMANTIFA_HUMANBioGRID, HPRD12566447 details
IRAK1_HUMANITAM_HUMANBioGRID, HPRD11701612 details
IRAK1_HUMANPP2AA_HUMANBioGRID21708940 details
IRAK1_HUMANTLR4_HUMANBioGRID, HPRD21911421 9625770 details
IRAK1_HUMANTLR9_HUMANBioGRID21911421 details
IRAK1_HUMANTNAP3_HUMANBioGRID21220427 details
IRAK1_HUMANM3K7_HUMANBioGRID, HPRD12242293 17197697 19026643 23244239 details
IRAK1_HUMANRCAN1_HUMANBioGRID19716405 details
IRAK1_HUMANIL1R1_HUMANBioGRID12242293 12609980 16024789 22904187 24735611 8599092 details
IRAK1_HUMANMK14_HUMANBioGRID, HPRD10346818 15388348 details
IRAK1_HUMANCAV1_HUMANBioGRID16107720 details
IRAK1_HUMANTRAF4_HUMANBioGRID, HPRD16052631 details
IRAK1_HUMANFBW1A_HUMANBioGRID22851693 details
IRAK1_HUMANFBW1B_HUMANBioGRID22851693 details
IRAK1_HUMANCUL1_HUMANBioGRID22851693 details
IRAK1_HUMANHS90A_HUMANBioGRID, HPRD15647277 details
IRAK1_HUMANCDC37_HUMANBioGRID15647277 details
IRAK1_HUMANHSP74_HUMANBioGRID15647277 details
IRAK1_HUMANSTIP1_HUMANBioGRID15647277 details
IRAK1_HUMANNAL12_HUMANBioGRID, HPRD16203735 details
IRAK1_HUMANBTK_HUMANBioGRID, HPRD12724322 details
IRAK1_HUMANSTAT3_HUMANBioGRID, HPRD15465816 details
IRAK1_HUMANKPCD_HUMANBioGRID21804018 details
IRAK1_HUMANSTAT1_HUMANBioGRID12856330 details
IRAK1_HUMANVASP_HUMANBioGRID20044140 details
IRAK1_HUMANF10A1_HUMANBioGRID15647277 details
IRAK1_HUMANPINK1_HUMANBioGRID23244239 31300519 details
IRAK1_HUMANILRL1_HUMANBioGRID16286016 details
IRAK1_HUMANM3K3_HUMANBioGRID17197697 details
IRAK1_HUMANSASH1_HUMANBioGRID23776175 details
IRAK1_HUMANRNF31_HUMANBioGRID24491438 details
IRAK1_HUMANIL1B_HUMANBioGRID10823834 details
IRAK1_HUMANRSAD2_HUMANBioGRID30872404 31921110 details
IRAK1_HUMANRN152_HUMANBioGRID31930677 details
IRAK1_HUMANRASH_HUMANHPRD11744690 details
IRAK1_HUMANNTRK3_HUMANHPRD12034707 details
IRAK1_HUMANFADD_HUMANHPRD11828002 details
IRAK1_HUMANTCAM2_HUMANHPRD12721283 details
IRAK1_HUMANKPCI_HUMANHPRD14684752 details
IRAK1_HUMANRIPK2_HUMANHPRD15691841 details
IRAK1_HUMANSUMO1_HUMANHPRD16690127 details
IRAK1_HUMANJUN_HUMANHPRD10346818 details
IRAK1_HUMANMBP_HUMANHPRD10346818 details