Entity Details

Primary name MP2K6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52564
EntryNameMP2K6_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 6
TaxID9606
Evidenceevidence at protein level
Length334
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K6

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001649 osteoblast differentiation
GO:0002931 response to ischemia
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006915 apoptotic process
GO:0006975 DNA damage induced protein phosphorylation
GO:0007165 signal transduction
GO:0019901 protein kinase binding
GO:0022602 ovulation cycle process
GO:0032308 positive regulation of prostaglandin secretion
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060048 cardiac muscle contraction
GO:0060348 bone development
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0072709 cellular response to sorbitol
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
MP2K6_HUMANM3K4_HUMANBioGRID, HPRD, IntAct12052864 15866172 16157600 17726008 25241761 9841871 details
MP2K6_HUMANMK14_HUMANBioGRID, HPRD, MINT11279118 12697810 16342939 17255097 17255949 28205554 7750576 8622669 8626699 9808624 details
MP2K6_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
MP2K6_HUMANLRRK2_HUMANBioGRID, IntAct19302196 20067578 details
MP2K6_HUMANTAOK2_HUMANBioGRID, HPRD, IntAct10497253 11279118 25241761 details
MP2K6_HUMANMP2K3_HUMANBioGRID, IntAct25241761 26186194 28205554 28514442 details
MP2K6_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
MP2K6_HUMANMP2K6_HUMANBioGRID, DIP, HPRD19141286 28205554 8622669 8663074 details
MP2K6_HUMANNF2L2_HUMANIntAct32911434 details
MP2K6_HUMANWFS1_HUMANIntAct32814053 details
MP2K6_HUMANM3K7_HUMANBioGRID, HPRD10094049 10702308 10838074 11460167 12242293 12556533 12609980 12624112 14633987 15590691 15764709 16893890 17079228 17363905 17363973 17384642 19675569 20932476 23606331 23825189 26038599 details
MP2K6_HUMANM3K5_HUMANBioGRID, HPRD11689443 12820963 15866172 16142216 20213747 25098452 details
MP2K6_HUMANTLR3_HUMANBioGRID12609980 details
MP2K6_HUMANMP2K4_HUMANBioGRID15866172 details
MP2K6_HUMANMK12_HUMANBioGRID, HPRD11062067 12761180 details
MP2K6_HUMANMAPK2_HUMANBioGRID17255097 details
MP2K6_HUMANMK01_HUMANBioGRID10512765 details
MP2K6_HUMANFBX7_HUMANBioGRID27503909 details
MP2K6_HUMANMP2K5_HUMANBioGRID28205554 details
MP2K6_HUMANBRAF_HUMANBioGRID28205554 details
MP2K6_HUMANAKT1_HUMANBioGRID28205554 details
MP2K6_HUMANBECN1_HUMANBioGRID28205554 details
MP2K6_HUMANCCND2_HUMANBioGRID28205554 details
MP2K6_HUMANCDN2B_HUMANBioGRID28205554 details
MP2K6_HUMANEPHA2_HUMANBioGRID28205554 details
MP2K6_HUMANFGFR4_HUMANBioGRID28205554 details
MP2K6_HUMANGLIS2_HUMANBioGRID28205554 details
MP2K6_HUMANHGF_HUMANBioGRID28205554 details
MP2K6_HUMANRASH_HUMANBioGRID28205554 details
MP2K6_HUMANRAF1_HUMANBioGRID28205554 details
MP2K6_HUMANSTK11_HUMANBioGRID28205554 details
MP2K6_HUMANRASF1_HUMANBioGRID28205554 details
MP2K6_HUMANDCTN1_HUMANHPRD15375157 details
MP2K6_HUMANPKN1_HUMANBioGRID, HPRD, IntAct12761180 details
MP2K6_HUMANTF65_HUMANBioGRID, HPRD, IntAct16498455 25241761 details
MP2K6_HUMANSMAD7_HUMANBioGRID, HPRD12589052 details
MP2K6_HUMANPLCB2_HUMANBioGRID, HPRD12054652 details
MP2K6_HUMANPTEN_HUMANBioGRID15717329 details
MP2K6_HUMANFBX31_HUMANBioGRID24936062 details
MP2K6_HUMANRACK1_HUMANBioGRID26038599 details
MP2K6_HUMANTRAF6_HUMANBioGRID, HPRD16313339 26038599 details
MP2K6_HUMANA4_HUMANBioGRID17719230 details
MP2K6_HUMANSTAT4_HUMANHPRD10961885 details
MP2K6_HUMANMK13_HUMANHPRD9218798 details
MP2K6_HUMANM3K20_HUMANHPRD11836244 details