Entity Details

Primary name NAL12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP59046
EntryNameNAL12_HUMAN
FullNameNACHT, LRR and PYD domains-containing protein 12
TaxID9606
Evidenceevidence at protein level
Length1061
SequenceStatuscomplete
DateCreated2002-10-19
DateModified2021-06-02

Ontological Relatives

GenesNLRP12

GO terms

Show/Hide Table
GOName
GO:0001818 negative regulation of cytokine production
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009968 negative regulation of signal transduction
GO:0031953 negative regulation of protein autophosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032661 regulation of interleukin-18 production
GO:0032692 negative regulation of interleukin-1 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045751 negative regulation of Toll signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0071345 cellular response to cytokine stimulus
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR004020 DAPIN domainDomainDomain
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029495 NACHT-associated domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

Show/Hide Table

Interactions

71 interactions

InteractorPartnerSourcesPublicationsLink
NAL12_HUMANPYDC2_HUMANUniProt17178784 details
NAL12_HUMANFLNA_HUMANI2D32226298 details
NAL12_HUMANMT2_HUMANI2D32226298 details
NAL12_HUMANDAZP2_HUMANI2D32226298 details
NAL12_HUMANDNJB1_HUMANI2D32226298 details
NAL12_HUMANCD14_HUMANI2D32226298 details
NAL12_HUMANDDX5_HUMANI2D32226298 details
NAL12_HUMANTLN1_HUMANI2D32226298 details
NAL12_HUMANCAMLG_HUMANI2D32226298 details
NAL12_HUMANSNUT1_HUMANI2D32226298 details
NAL12_HUMANRANB9_HUMANI2D32226298 details
NAL12_HUMANT3JAM_HUMANI2D32226298 details
NAL12_HUMANTRIP4_HUMANI2D32226298 details
NAL12_HUMANRS20_HUMANI2D32226298 details
NAL12_HUMANCOR1A_HUMANI2D32226298 details
NAL12_HUMANGLNA_HUMANI2D32226298 details
NAL12_HUMANACTB_HUMANI2D32226298 details
NAL12_HUMANWAC_HUMANI2D32226298 details
NAL12_HUMANRNC_HUMANI2D32226298 details
NAL12_HUMANDNJA3_HUMANI2D32226298 details
NAL12_HUMANPTPRE_HUMANI2D32226298 details
NAL12_HUMANUBQL1_HUMANI2D32226298 details
NAL12_HUMANBIRC3_HUMANI2D32226298 details
NAL12_HUMANTNR6C_HUMANI2D32226298 details
NAL12_HUMANPPBT_HUMANI2D32226298 details
NAL12_HUMANPRP6_HUMANI2D32226298 details
NAL12_HUMANUBX2B_HUMANI2D32226298 details
NAL12_HUMANBAG6_HUMANI2D32226298 details
NAL12_HUMANSCTM1_HUMANI2D32226298 details
NAL12_HUMANSAT2_HUMANI2D32226298 details
NAL12_HUMANZN426_HUMANI2D32226298 details
NAL12_HUMANHLAB_HUMANI2D32226298 details
NAL12_HUMANFBN2_HUMANI2D32226298 details
NAL12_HUMAN3BP2_HUMANI2D32226298 details
NAL12_HUMANMYO1F_HUMANI2D32226298 details
NAL12_HUMANFRIH_HUMANI2D32226298 details
NAL12_HUMANLRC42_HUMANI2D32226298 details
NAL12_HUMANURP2_HUMANI2D32226298 details
NAL12_HUMANLEG9B_HUMANI2D32226298 details
NAL12_HUMANSODM_HUMANI2D32226298 details
NAL12_HUMANCHSTF_HUMANI2D32226298 details
NAL12_HUMANHAX1_HUMANI2D32226298 details
NAL12_HUMANHLAC_HUMANI2D32226298 details
NAL12_HUMANAK17A_HUMANI2D32226298 details
NAL12_HUMANIL8_HUMANI2D32226298 details
NAL12_HUMANHCK_HUMANI2D32226298 details
NAL12_HUMANCAP1_HUMANI2D32226298 details
NAL12_HUMANAKIP1_HUMANI2D32226298 details
NAL12_HUMANUBQL2_HUMANI2D32226298 details
NAL12_HUMANFAF1_HUMANBioGRID17046979 details
NAL12_HUMANFKBP5_HUMANIntAct25036637 details
NAL12_HUMANMLF1_HUMANIntAct25036637 details
NAL12_HUMANMLF2_HUMANIntAct25036637 details
NAL12_HUMANHSF2_HUMANIntAct25036637 details
NAL12_HUMANNUDC3_HUMANIntAct25036637 details
NAL12_HUMANSGTA_HUMANIntAct25036637 details
NAL12_HUMANPSMD2_HUMANIntAct25036637 details
NAL12_HUMANFKBPL_HUMANIntAct25036637 details
NAL12_HUMANSTIP1_HUMANIntAct25036637 details
NAL12_HUMANHS90A_HUMANBioGRID, IntAct17947705 25036637 details
NAL12_HUMANPTG3L_HUMANIntAct25036637 details
NAL12_HUMANAASD1_HUMANIntAct25036637 details
NAL12_HUMANCYBP_HUMANIntAct25036637 details
NAL12_HUMANCHIP_HUMANIntAct25036637 details
NAL12_HUMANCDC37_HUMANIntAct25036637 details
NAL12_HUMANTTC1_HUMANIntAct25036637 details
NAL12_HUMANIRAK1_HUMANBioGRID, HPRD16203735 details
NAL12_HUMANHSP74_HUMANBioGRID17947705 details
NAL12_HUMANHSP7C_HUMANBioGRID17947705 details
NAL12_HUMANTRI25_HUMANBioGRID30902577 details
NAL12_HUMANASC_HUMANHPRD12019269 details