Entity Details

Primary name TGFB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61812
EntryNameTGFB2_HUMAN
FullNameTransforming growth factor beta-2 proprotein
TaxID9606
Evidenceevidence at protein level
Length414
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesTGFB2

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0001501 skeletal system development
GO:0001540 amyloid-beta binding
GO:0001654 eye development
GO:0001666 response to hypoxia
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001843 neural tube closure
GO:0001942 hair follicle development
GO:0002576 platelet degranulation
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003179 heart valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003274 endocardial cushion fusion
GO:0003289 atrial septum primum morphogenesis
GO:0003407 neural retina development
GO:0005102 signaling receptor binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007435 salivary gland morphogenesis
GO:0007507 heart development
GO:0008083 growth factor activity
GO:0008219 cell death
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008347 glial cell migration
GO:0008584 male gonad development
GO:0009611 response to wounding
GO:0009792 embryo development ending in birth or egg hatching
GO:0010002 cardioblast differentiation
GO:0010629 negative regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030097 hemopoiesis
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030424 axon
GO:0030509 BMP signaling pathway
GO:0030593 neutrophil chemotaxis
GO:0031069 hair follicle morphogenesis
GO:0031093 platelet alpha granule lumen
GO:0032147 activation of protein kinase activity
GO:0032570 response to progesterone
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032909 regulation of transforming growth factor beta2 production
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0034714 type III transforming growth factor beta receptor binding
GO:0035910 ascending aorta morphogenesis
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042416 dopamine biosynthetic process
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042704 uterine wall breakdown
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043525 positive regulation of neuron apoptotic process
GO:0045216 cell-cell junction organization
GO:0045726 positive regulation of integrin biosynthetic process
GO:0045747 positive regulation of Notch signaling pathway
GO:0045778 positive regulation of ossification
GO:0045787 positive regulation of cell cycle
GO:0045823 positive regulation of heart contraction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048103 somatic stem cell division
GO:0048566 embryonic digestive tract development
GO:0048666 neuron development
GO:0048699 generation of neurons
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050778 positive regulation of immune response
GO:0051781 positive regulation of cell division
GO:0051794 regulation of timing of catagen
GO:0051795 positive regulation of timing of catagen
GO:0051891 positive regulation of cardioblast differentiation
GO:0060038 cardiac muscle cell proliferation
GO:0060065 uterus development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0061626 pharyngeal arch artery morphogenesis
GO:0062009 secondary palate development
GO:0062023 collagen-containing extracellular matrix
GO:0097191 extrinsic apoptotic signaling pathway
GO:1902256 regulation of apoptotic process involved in outflow tract morphogenesis
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903701 substantia propria of cornea development
GO:1904888 cranial skeletal system development
GO:1905006 negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR003940 Transforming growth factor beta-2 proproteinFamilyFamily
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR016319 Transforming growth factor-betaFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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