Entity Details

Primary name GBB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62873
EntryNameGBB1_HUMAN
FullNameGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
TaxID9606
Evidenceevidence at protein level
Length340
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesGNB1

GO terms

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GOName
GO:0001917 photoreceptor inner segment
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003924 GTPase activity
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0006457 protein folding
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007265 Ras protein signal transduction
GO:0008283 cell population proliferation
GO:0010659 cardiac muscle cell apoptotic process
GO:0016020 membrane
GO:0016056 rhodopsin mediated signaling pathway
GO:0030168 platelet activation
GO:0030425 dendrite
GO:0030507 spectrin binding
GO:0031682 G-protein gamma-subunit binding
GO:0042622 photoreceptor outer segment membrane
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity
GO:0050909 sensory perception of taste
GO:0051020 GTPase binding
GO:0060041 retina development in camera-type eye
GO:0070062 extracellular exosome
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071456 cellular response to hypoxia
GO:0071870 cellular response to catecholamine stimulus
GO:0097381 photoreceptor disc membrane
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1903561 extracellular vesicle

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001632 G-protein, beta subunitDomainDomain
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016346 Guanine nucleotide-binding protein, beta subunitFamilyFamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616973 OMIMMental retardation, autosomal dominant 42 (MRD42)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD42 patients manifest global developmental delay commonly accompanied by hypotonia, seizures of various types, ophthalmological manifestations, and poor growth. The disease is caused by variants affecting the gene represented in this entry.

Interactions

103 interactions

InteractorPartnerSourcesPublicationsLink
GBB1_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
GBB1_HUMANCYFP1_HUMANBioGRID, IntAct21988832 details
GBB1_HUMANGNAI2_HUMANBioGRID, MINT16371464 16782902 22939629 details
GBB1_HUMANCTNA3_HUMANBioGRID, IntAct32296183 details
GBB1_HUMANFETA_HUMANBioGRID, IntAct21988832 details
GBB1_HUMANNOL11_HUMANBioGRID, IntAct21988832 details
GBB1_HUMANGNAI1_HUMANBioGRID, IntAct16371464 22939629 28514442 details
GBB1_HUMANEPHA7_HUMANBioGRID, IntAct21988832 details
GBB1_HUMANHD_HUMANIntAct17500595 32814053 details
GBB1_HUMANGBG3_HUMANBioGRID, HPRD, IntAct11294873 12782285 16301321 19168127 28514442 8636150 details
GBB1_HUMANGNAI3_HUMANBioGRID, IntAct16371464 22186894 22939629 26186194 28514442 details
GBB1_HUMANGBG5_HUMANBioGRID, HPRD, IntAct12782285 19168127 25416956 8636150 details
GBB1_HUMANGBG4_HUMANBioGRID, HPRD, IntAct12782285 16884933 19168127 28514442 7665596 8636150 details
GBB1_HUMANGNAS2_HUMANBioGRID, IntAct15782186 26186194 28514442 details
GBB1_HUMANGBG2_HUMANBioGRID, DIP, HPRD10339615 11294873 12606627 12782285 15782186 15889144 16301321 19168127 19376773 23739333 29899455 31168089 31243364 32528175 8636150 9789084 details
GBB1_HUMANVAC14_HUMANBioGRID, IntAct32296183 details
GBB1_HUMANDPF1_HUMANIntAct32814053 details
GBB1_HUMANKCNJ3_HUMANBioGRID, HPRD12743112 9108307 details
GBB1_HUMANPDIA1_HUMANIntAct32814053 details
GBB1_HUMANGBG13_HUMANBioGRID, HPRD10570481 12782285 16301321 19168127 details
GBB1_HUMANGBG10_HUMANBioGRID12782285 16301321 19168127 7665596 details
GBB1_HUMANGBG11_HUMANBioGRID, HPRD12782285 16301321 19168127 7665596 details
GBB1_HUMANHDAC5_HUMANBioGRID, HPRD16221676 details
GBB1_HUMANWDR26_HUMANBioGRID22065575 23625927 26895380 details
GBB1_HUMANGBG1_HUMANBioGRID, HPRD12782285 19168127 25675501 8636150 9789084 details
GBB1_HUMANATX10_HUMANBioGRID16498633 details
GBB1_HUMANMCF2_HUMANBioGRID10518015 details
GBB1_HUMANARBK1_HUMANBioGRID10744734 15102938 17548351 details
GBB1_HUMANGBG7_HUMANBioGRID, HPRD12782285 16301321 19168127 28087732 8308009 8636150 details
GBB1_HUMANADRB2_HUMANBioGRID15782186 23798571 details
GBB1_HUMANPKHG2_HUMANBioGRID18045877 27765816 details
GBB1_HUMANGNAS3_HUMANBioGRID15782186 26186194 28514442 details
GBB1_HUMANRASD1_HUMANBioGRID, HPRD16225846 details
GBB1_HUMANALEX_HUMANBioGRID15782186 26186194 28514442 details
GBB1_HUMANPHLP_HUMANBioGRID, HPRD15889144 19376773 25675501 details
GBB1_HUMANARRB1_HUMANBioGRID18729826 32505358 details
GBB1_HUMANGCR_HUMANBioGRID15955845 details
GBB1_HUMANGBGT2_HUMANBioGRID19168127 8636150 details
GBB1_HUMANGBG12_HUMANBioGRID12782285 16301321 19168127 details
GBB1_HUMANRHES_HUMANBioGRID19255495 details
GBB1_HUMANSPAG1_HUMANBioGRID16368546 details
GBB1_HUMANGNAS1_HUMANBioGRID15782186 26186194 28514442 details
GBB1_HUMANGBG8_HUMANBioGRID12782285 details
GBB1_HUMANMTOR_HUMANBioGRID24462769 details
GBB1_HUMANCDC42_HUMANBioGRID31478661 details
GBB1_HUMANCAC1C_HUMANHPRD15953418 details
GBB1_HUMANHDAC4_HUMANBioGRID16221676 31040226 details
GBB1_HUMANV2R_HUMANBioGRID15782186 details
GBB1_HUMANADA2A_HUMANBioGRID15782186 details
GBB1_HUMANMRGX1_HUMANBioGRID15782186 details
GBB1_HUMANTA2R_HUMANBioGRID12399457 15782186 details
GBB1_HUMANCAC1B_HUMANHPRD15953418 details
GBB1_HUMANRIPK3_HUMANIntAct14743216 details
GBB1_HUMANM3K3_HUMANIntAct14743216 details
GBB1_HUMANNCF2_HUMANBioGRID, MINT16782902 details
GBB1_HUMANMLF1_HUMANIntAct25036637 details
GBB1_HUMANCRCM_HUMANIntAct17353931 details
GBB1_HUMANMLF2_HUMANIntAct25036637 details
GBB1_HUMANAASD1_HUMANIntAct25036637 details
GBB1_HUMANSTIP1_HUMANIntAct25036637 details
GBB1_HUMANPSMD2_HUMANIntAct25036637 details
GBB1_HUMANARHGI_HUMANBioGRID, HPRD14512443 details
GBB1_HUMANRACK1_HUMANBioGRID, HPRD12359736 18596232 19917775 22065575 details
GBB1_HUMANNUDC3_HUMANIntAct25036637 details
GBB1_HUMANPFD5_HUMANIntAct25036637 details
GBB1_HUMANPTG3L_HUMANIntAct25036637 details
GBB1_HUMANRADIL_HUMANBioGRID20048162 details
GBB1_HUMANRAP1A_HUMANBioGRID20048162 details
GBB1_HUMANPAK1_HUMANBioGRID12887923 details
GBB1_HUMANUBQL1_HUMANBioGRID14662753 details
GBB1_HUMANAKT1_HUMANBioGRID16027165 19117013 details
GBB1_HUMANKALRN_HUMANBioGRID10518015 details
GBB1_HUMANTCPE_HUMANBioGRID19376773 details
GBB1_HUMANRICTR_HUMANBioGRID24462769 details
GBB1_HUMANRPTOR_HUMANBioGRID24462769 details
GBB1_HUMANRGS6_HUMANBioGRID10339615 details
GBB1_HUMANFYN_HUMANBioGRID19917775 details
GBB1_HUMANP85A_HUMANBioGRID19117013 details
GBB1_HUMANVATB1_HUMANBioGRID21674799 details
GBB1_HUMANMCF2L_HUMANBioGRID10518015 details
GBB1_HUMANCUL4A_HUMANBioGRID25982117 details
GBB1_HUMANFHL1_HUMANBioGRID27765816 details
GBB1_HUMANSVIL_HUMANBioGRID12202484 details
GBB1_HUMANBTK_HUMANBioGRID11698416 details
GBB1_HUMANGLI1_HUMANBioGRID26603838 details
GBB1_HUMANABCE1_HUMANBioGRID25659154 details
GBB1_HUMANKPCB_HUMANBioGRID31634457 details
GBB1_HUMANFAK1_HUMANBioGRID19917775 details
GBB1_HUMANPK3CB_HUMANBioGRID26895380 details
GBB1_HUMANPK3CA_HUMANBioGRID19117013 details
GBB1_HUMANCAC1A_HUMANHPRD9009193 details
GBB1_HUMANAKT2_HUMANBioGRID26895380 details
GBB1_HUMANPP1B_HUMANBioGRID28615442 details
GBB1_HUMANPP1A_HUMANBioGRID28615442 details
GBB1_HUMANMTR1B_HUMANHPRD17215244 details
GBB1_HUMANPP1G_HUMANBioGRID28615442 30344098 details
GBB1_HUMANSMO_HUMANBioGRID31168089 details
GBB1_HUMANGNAO_HUMANBioGRID32505358 details
GBB1_HUMANGABR1_HUMANBioGRID16809021 details
GBB1_HUMANARRB2_HUMANBioGRID32505358 details
GBB1_HUMANPTH1R_HUMANHPRD16099817 details
GBB1_HUMANGNA12_HUMANHPRD7829508 details
GBB1_HUMANDJC25_HUMANHPRD7665596 details