Entity Details

Primary name DLG4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78352
EntryNameDLG4_HUMAN
FullNameDisks large homolog 4
TaxID9606
Evidenceevidence at protein level
Length724
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDLG4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002091 negative regulation of receptor internalization
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 chemical synaptic transmission
GO:0007399 nervous system development
GO:0007612 learning
GO:0008021 synaptic vesicle
GO:0008022 protein C-terminus binding
GO:0014069 postsynaptic density
GO:0016188 synaptic vesicle maturation
GO:0019900 kinase binding
GO:0019903 protein phosphatase binding
GO:0030054 cell junction
GO:0030165 PDZ domain binding
GO:0030666 endocytic vesicle membrane
GO:0030863 cortical cytoskeleton
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031594 neuromuscular junction
GO:0031697 beta-1 adrenergic receptor binding
GO:0031748 D1 dopamine receptor binding
GO:0031812 P2Y1 nucleotide receptor binding
GO:0032281 AMPA glutamate receptor complex
GO:0032839 dendrite cytoplasm
GO:0033130 acetylcholine receptor binding
GO:0035176 social behavior
GO:0035255 ionotropic glutamate receptor binding
GO:0035418 protein localization to synapse
GO:0035641 locomotory exploration behavior
GO:0035865 cellular response to potassium ion
GO:0043005 neuron projection
GO:0043113 receptor clustering
GO:0043197 dendritic spine
GO:0044224 juxtaparanode region of axon
GO:0044300 cerebellar mossy fiber
GO:0044306 neuron projection terminus
GO:0044309 neuron spine
GO:0044877 protein-containing complex binding
GO:0045184 establishment of protein localization
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050806 positive regulation of synaptic transmission
GO:0050885 neuromuscular process controlling balance
GO:0060076 excitatory synapse
GO:0060997 dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0065003 protein-containing complex assembly
GO:0071625 vocalization behavior
GO:0097060 synaptic membrane
GO:0097109 neuroligin family protein binding
GO:0097110 scaffold protein binding
GO:0097113 AMPA glutamate receptor clustering
GO:0097120 receptor localization to synapse
GO:0098609 cell-cell adhesion
GO:0098839 postsynaptic density membrane
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
GO:0098978 glutamatergic synapse
GO:0150012 positive regulation of neuron projection arborization
GO:2000310 regulation of NMDA receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000821 regulation of grooming behavior

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR008144 Guanylate kinase-like domainDomainDomain
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR016313 Disks large 1-likeFamilyFamily
IPR019583 PDZ-associated domain of NMDA receptorsDomainDomain
IPR019590 Disks large homologue 1, N-terminal PEST domainDomainDomain
IPR020590 Guanylate kinase, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618793 OMIMIntellectual developmental disorder, autosomal dominant 62 (MRD62)An autosomal dominant form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD62 is characterized by mild to moderately impaired intellectual development. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00536 GuanidineDrugbanksmall molecule
DB01972 Guanosine-5'-MonophosphateDrugbanksmall molecule

Interactions

159 interactions

InteractorPartnerSourcesPublicationsLink
DLG4_HUMANERBB4_HUMANBioGRID, HPRD, IntAct, MINT10725395 10839362 12716924 16767099 17018285 details
DLG4_HUMANKI13B_HUMANBioGRID, HPRD, IntAct10859302 details
DLG4_HUMANKIF1B_HUMANHPRD, IntAct12097473 details
DLG4_HUMANNMDE2_HUMANBioGRID, DIP, HPRD, MINT10488080 11723117 11937501 11997254 12738960 16332682 16990796 17459877 20018661 20869595 7569905 8601796 9278515 9581762 details
DLG4_HUMANNMDE1_HUMANBioGRID, DIP, HPRD, MINT10336672 10648730 11222640 11937501 12419528 14732708 16332682 16990796 17360663 17459877 18400955 20869595 21653829 22375001 23183381 7569905 8601796 9278515 9286858 details
DLG4_HUMANNMDE3_HUMANBioGRID, HPRD, MINT11937501 7569905 details
DLG4_HUMANNMDZ1_HUMANBioGRID, HPRD, MINT11506858 11937501 12068077 14732708 15030493 16767099 17459877 22375001 9009191 9502803 details
DLG4_HUMANKCNA1_HUMANBioGRID, HPRD, MINT11937501 12435606 7477295 8938729 details
DLG4_HUMANKCNA4_HUMANBioGRID, HPRD, MINT11723117 11744724 11937501 11997254 12435606 7477295 8601796 8938729 9581762 details
DLG4_HUMANCRIPT_HUMANBioGRID, DIP, HPRD, MINT11744724 11937501 20018661 9581762 details
DLG4_HUMANNLGN1_HUMANBioGRID, HPRD, MINT11937501 30864948 9278515 details
DLG4_HUMANNMDE4_HUMANHPRD, MINT11937501 7569905 details
DLG4_HUMANGRB2_HUMANIntAct17474147 details
DLG4_HUMANMED28_HUMANBioGRID, MINT16964398 details
DLG4_HUMANSPR2A_HUMANBioGRID, MINT18155796 details
DLG4_HUMANDLGP1_HUMANBioGRID, HPRD, MINT10527873 10844022 11060025 21653829 22117215 28973854 9024696 9115257 9286858 details
DLG4_HUMANSI1L1_HUMANBioGRID, HPRD, MINT11502259 21653829 22117215 28973854 details
DLG4_HUMANMDM2_HUMANBioGRID, IntAct23260144 details
DLG4_HUMANLRP1_HUMANBioGRID, DIP, HPRD10827173 17360663 details
DLG4_HUMANARHG8_HUMANIntAct30126976 details
DLG4_HUMANCDC5L_HUMANIntAct30126976 details
DLG4_HUMANPKP4_HUMANIntAct30126976 details
DLG4_HUMANTANC1_HUMANHPRD, IntAct15673434 30126976 details
DLG4_HUMANRBP1_HUMANIntAct, MINT21653829 30126976 details
DLG4_HUMANFRPD4_HUMANIntAct30126976 details
DLG4_HUMANGCYA2_HUMANBioGRID, HPRD, IntAct11572861 30126976 details
DLG4_HUMANCLTR2_HUMANIntAct30126976 details
DLG4_HUMANCTND2_HUMANIntAct30126976 details
DLG4_HUMANPRKN_HUMANBioGRID, IntAct11679592 32814053 details
DLG4_HUMANACTN2_HUMANBioGRID, HPRD, MINT12435606 21653829 details
DLG4_HUMANDLGP3_HUMANBioGRID, MINT21653829 9115257 details
DLG4_HUMANDLG4_HUMANBioGRID, HPRD, MINT10995758 11937501 21653829 9182804 details
DLG4_HUMANBEGIN_HUMANHPRD, MINT21653829 9756850 details
DLG4_HUMANDLGP4_HUMANBioGRID, HPRD, MINT21653829 9115257 details
DLG4_HUMANSYGP1_HUMANBioGRID, HPRD, MINT21653829 9581761 details
DLG4_HUMANKCNJ4_HUMANBioGRID, HPRD10627592 11997254 14960569 details
DLG4_HUMANKCNJ2_HUMANBioGRID, HPRD10627592 details
DLG4_HUMANASIC3_HUMANBioGRID, HPRD15317815 details
DLG4_HUMANKCNA5_HUMANBioGRID, HPRD12435606 12860415 16466689 details
DLG4_HUMANEXOC4_HUMANBioGRID12675619 12738960 details
DLG4_HUMANLRP2_HUMANBioGRID, HPRD10827173 12713445 details
DLG4_HUMANGRIK1_HUMANBioGRID, HPRD12597860 details
DLG4_HUMANGRIK2_HUMANBioGRID, HPRD11276111 11279111 11744724 12597860 9808460 details
DLG4_HUMANFAK2_HUMANBioGRID, HPRD12576483 details
DLG4_HUMANCCG2_HUMANBioGRID, HPRD11140673 11805122 12359873 details
DLG4_HUMANLRP8_HUMANBioGRID, HPRD10827173 16332682 details
DLG4_HUMANCSKP_HUMANBioGRID, HPRD12151521 details
DLG4_HUMANHGS_HUMANBioGRID, HPRD12151521 details
DLG4_HUMANDYL2_HUMANBioGRID10844022 details
DLG4_HUMANDYL1_HUMANBioGRID, HPRD10844022 14760703 details
DLG4_HUMANSHAN2_HUMANBioGRID, HPRD10527873 10844022 details
DLG4_HUMANDLG3_HUMANBioGRID, HPRD10026200 28973854 details
DLG4_HUMANERBB2_HUMANBioGRID, HPRD10839362 details
DLG4_HUMANNLGN2_HUMANBioGRID, HPRD9278515 details
DLG4_HUMANNLGN3_HUMANBioGRID, HPRD9278515 details
DLG4_HUMANGRIK5_HUMANBioGRID, HPRD11279111 9808460 details
DLG4_HUMANADRB1_HUMANBioGRID, HPRD10995758 11526121 16316992 details
DLG4_HUMANPTPRG_HUMANBioGRID, HPRD10521598 details
DLG4_HUMANSEM4C_HUMANBioGRID, HPRD11134026 15978582 details
DLG4_HUMAN5HT2C_HUMANBioGRID, HPRD12006486 details
DLG4_HUMANLRRC1_HUMANBioGRID, HPRD11440998 details
DLG4_HUMANMAP1A_HUMANBioGRID, HPRD11925566 9786987 details
DLG4_HUMANNOS1_HUMANBioGRID, HPRD10488080 8625413 9459447 details
DLG4_HUMANFZD1_HUMANBioGRID, HPRD12067714 details
DLG4_HUMANFZD2_HUMANBioGRID, HPRD12067714 details
DLG4_HUMANFZD4_HUMANBioGRID, HPRD12067714 details
DLG4_HUMANFZD7_HUMANBioGRID, HPRD12067714 details
DLG4_HUMANKCND2_HUMANBioGRID, HPRD12435606 details
DLG4_HUMANKCNA2_HUMANBioGRID, HPRD12435606 12438413 7477295 8938729 details
DLG4_HUMANAGRB1_HUMANBioGRID, HPRD11937501 23782696 details
DLG4_HUMANLIN7A_HUMANBioGRID, HPRD10341223 details
DLG4_HUMANMCP_HUMANBioGRID, HPRD11714708 details
DLG4_HUMANKHDR1_HUMANBioGRID22745667 details
DLG4_HUMANKCNA3_HUMANBioGRID, HPRD12435606 17854350 21726550 8938729 details
DLG4_HUMANPCD10_HUMANBioGRID23260144 details
DLG4_HUMANTRAF6_HUMANBioGRID28973854 details
DLG4_HUMANCYLD_HUMANBioGRID28973854 details
DLG4_HUMANKS6A1_HUMANBioGRID30726710 details
DLG4_HUMANCRFR1_HUMANBioGRID23576434 26898829 details
DLG4_HUMANARRB2_HUMANBioGRID26898829 details
DLG4_HUMANS4A7_HUMANBioGRID23183381 details
DLG4_HUMANDRD1_HUMANBioGRID23041629 details
DLG4_HUMANAGRL1_HUMANHPRD10958799 details
DLG4_HUMANI13R1_HUMANHPRD7569905 details
DLG4_HUMANKCJ10_HUMANHPRD9148889 details
DLG4_HUMANSEM4F_HUMANHPRD11483650 details
DLG4_HUMANCNKR2_HUMANHPRD10207009 details
DLG4_HUMANGUAD_HUMANHPRD10595517 details
DLG4_HUMANDLGP2_HUMANHPRD9115257 9286858 details
DLG4_HUMANCTRO_HUMANHPRD9870942 details
DLG4_HUMANNMD3A_HUMANHPRD7569905 details
DLG4_HUMANNDOR1_HUMANHPRD7569905 details
DLG4_HUMANGRASP_HUMANHPRD12586822 details
DLG4_HUMANEFNB2_HUMANHPRD15458844 details
DLG4_HUMANWNT3A_HUMANHPRD12067714 details
DLG4_HUMANGBG13_HUMANHPRD16473877 details
DLG4_HUMANA4_HUMANMINT20573181 details
DLG4_HUMANNTRK2_HUMANDIP23424281 details
DLG4_HUMANARC_HUMANDIP23424281 details
DLG4_HUMANCLUS_HUMANMINT21653829 details
DLG4_HUMANDLG2_HUMANBioGRID, HPRD, MINT21653829 9182804 details
DLG4_HUMANAGRB2_HUMANMINT21653829 details
DLG4_HUMANHNRPC_HUMANMINT21653829 details
DLG4_HUMANGPSM2_HUMANMINT21653829 details
DLG4_HUMANGOGA2_HUMANMINT21653829 details
DLG4_HUMANFRIH_HUMANMINT21653829 details
DLG4_HUMANCOX1_HUMANMINT21653829 details
DLG4_HUMANEM55_HUMANMINT21653829 details
DLG4_HUMANLZTS2_HUMANMINT21653829 details
DLG4_HUMANMPND_HUMANMINT21653829 details
DLG4_HUMANEF1G_HUMANMINT21653829 details
DLG4_HUMANAB17A_HUMANMINT21653829 details
DLG4_HUMANWDR74_HUMANMINT21653829 details
DLG4_HUMANVMAC_HUMANMINT21653829 details
DLG4_HUMANTBB2B_HUMANMINT21653829 details
DLG4_HUMANTJAP1_HUMANMINT21653829 details
DLG4_HUMANTHOC3_HUMANMINT21653829 details
DLG4_HUMANRASF4_HUMANMINT21653829 details
DLG4_HUMANLARGN_HUMANMINT21653829 details
DLG4_HUMANPICK1_HUMANMINT21653829 details
DLG4_HUMANPEX19_HUMANMINT21653829 details
DLG4_HUMANPIMT_HUMANMINT21653829 details
DLG4_HUMANNOMO1_HUMANMINT21653829 details
DLG4_HUMANKCJ12_HUMANBioGRID, HPRD14960569 15024025 details
DLG4_HUMAN5HT2A_HUMANBioGRID, HPRD12682061 details
DLG4_HUMANADA22_HUMANBioGRID16990550 details
DLG4_HUMANLGI1_HUMANBioGRID16990550 details
DLG4_HUMANGRIA2_HUMANBioGRID16990550 details
DLG4_HUMANGRIA3_HUMANBioGRID16990550 details
DLG4_HUMANFYN_HUMANBioGRID, HPRD12419528 9892651 details
DLG4_HUMANNLGNX_HUMANBioGRID, HPRD11368788 details
DLG4_HUMANM3K10_HUMANBioGRID, HPRD11152698 details
DLG4_HUMANM3K11_HUMANBioGRID11152698 details
DLG4_HUMANKPCA_HUMANBioGRID, HPRD11937501 details
DLG4_HUMANLIN7B_HUMANBioGRID, HPRD10341223 details
DLG4_HUMANRD23A_HUMANBioGRID23260144 details
DLG4_HUMANPTN5_HUMANBioGRID27457929 details
DLG4_HUMANDP13A_HUMANBioGRID27300007 details
DLG4_HUMANCNTP2_HUMANBioGRID12438413 details
DLG4_HUMANBAIP2_HUMANBioGRID15255944 details
DLG4_HUMANSHAN1_HUMANBioGRID, HPRD10433268 15255944 details
DLG4_HUMANEAA3_HUMANBioGRID17459877 details
DLG4_HUMANYES_HUMANHPRD9892651 details
DLG4_HUMANLYN_HUMANHPRD9892651 details
DLG4_HUMANAT2B4_HUMANHPRD11274188 details
DLG4_HUMANAT2B2_HUMANHPRD11274188 details
DLG4_HUMANAKAP5_HUMANHPRD10939335 details
DLG4_HUMANERBIN_HUMANHPRD11279080 details
DLG4_HUMANZDH17_HUMANHPRD15603740 details
DLG4_HUMANRHG32_HUMANHPRD12531901 details
DLG4_HUMANHD_HUMANHPRD11319238 details
DLG4_HUMANSCN5A_HUMANHPRD16637659 details
DLG4_HUMANMK12_HUMANHPRD16637659 details
DLG4_HUMANGLSL_HUMANHPRD16637659 details
DLG4_HUMANLRFN1_HUMANHPRD16828986 details
DLG4_HUMANSEM4B_HUMANHPRD15978582 details
DLG4_HUMANSEM4G_HUMANHPRD15978582 details
DLG4_HUMANSRC_HUMANHPRD16990796 details
DLG4_HUMANSPN90_HUMANHPRD16990791 details