Entity Details

Primary name DHI2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP80365
EntryNameDHI2_HUMAN
FullNameCorticosteroid 11-beta-dehydrogenase isozyme 2
TaxID9606
Evidenceevidence at protein level
Length405
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesHSD11B2

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0002017 regulation of blood volume by renal aldosterone
GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
GO:0005496 steroid binding
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0006704 glucocorticoid biosynthetic process
GO:0007565 female pregnancy
GO:0032094 response to food
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0051287 NAD binding
GO:0051384 response to glucocorticoid

Subcellular Location

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Subcellular Location
Endoplasmic reticulum
Microsome

Domains

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DomainNameCategoryType
IPR002347 Short-chain dehydrogenase/reductase SDRFamilyFamily
IPR020904 Short-chain dehydrogenase/reductase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00687 FludrocortisoneDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB01185 FluoxymesteroneDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01569 FormeboloneDrugbanksmall molecule
DB14538 Hydrocortisone aceponateDrugbanksmall molecule
DB14539 Hydrocortisone acetateDrugbanksmall molecule
DB14540 Hydrocortisone butyrateDrugbanksmall molecule
DB14541 Hydrocortisone cypionateDrugbanksmall molecule
DB14542 Hydrocortisone phosphateDrugbanksmall molecule
DB14543 Hydrocortisone probutateDrugbanksmall molecule
DB14544 Hydrocortisone valerateDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule

Interactions

4 interactions