Entity Details

Primary name CRUM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP82279
EntryNameCRUM1_HUMAN
FullNameProtein crumbs homolog 1
TaxID9606
Evidenceevidence at protein level
Length1406
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesCRB1

GO terms

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GOName
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0001974 blood vessel remodeling
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005912 adherens junction
GO:0007009 plasma membrane organization
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007163 establishment or maintenance of cell polarity
GO:0007267 cell-cell signaling
GO:0010001 glial cell differentiation
GO:0010467 gene expression
GO:0010842 retina layer formation
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0032991 protein-containing complex
GO:0034613 cellular protein localization
GO:0035845 photoreceptor cell outer segment organization
GO:0042462 eye photoreceptor cell development
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045494 photoreceptor cell maintenance
GO:0050908 detection of light stimulus involved in visual perception
GO:0060060 post-embryonic retina morphogenesis in camera-type eye
GO:0061159 establishment of bipolar cell polarity involved in cell morphogenesis
GO:0071482 cellular response to light stimulus

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell projection
Photoreceptor inner segment
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR013032 EGF-like, conserved siteSiteConserved site
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site

Diseases

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