Entity Details

Primary name CP27A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02318
EntryNameCP27A_HUMAN
FullNameSterol 26-hydroxylase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length531
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesCYP27A1

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006699 bile acid biosynthetic process
GO:0006707 cholesterol catabolic process
GO:0008203 cholesterol metabolic process
GO:0008395 steroid hydroxylase activity
GO:0016125 sterol metabolic process
GO:0020037 heme binding
GO:0030343 vitamin D3 25-hydroxylase activity
GO:0031073 cholesterol 26-hydroxylase activity
GO:0036378 calcitriol biosynthetic process from calciol
GO:0047748 cholestanetetraol 26-dehydrogenase activity
GO:0047749 cholestanetriol 26-monooxygenase activity

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00082 PegvisomantDrugbankbiotech
DB00153 ErgocalciferolDrugbanksmall molecule
DB00169 CholecalciferolDrugbanksmall molecule
DB06410 DoxercalciferolDrugbanksmall molecule
DB06777 Chenodeoxycholic acidDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CP27A_HUMANPRDX4_HUMANBioGRID, IntAct21988832 details