Entity Details

Primary name PAX5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02548
EntryNamePAX5_HUMAN
FullNamePaired box protein Pax-5
TaxID9606
Evidenceevidence at protein level
Length391
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesPAX5

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001650 fibrillar center
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006959 humoral immune response
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0007568 aging
GO:0009887 animal organ morphogenesis
GO:0021670 lateral ventricle development
GO:0021987 cerebral cortex development
GO:0030534 adult behavior
GO:0035914 skeletal muscle cell differentiation
GO:0043231 intracellular membrane-bounded organelle
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048856 anatomical structure development
GO:0050855 regulation of B cell receptor signaling pathway
GO:0051573 negative regulation of histone H3-K9 methylation

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001523 Paired domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR022130 Paired-box protein 2 C-terminalDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR043182 Paired DNA-binding domainDomainDomain
IPR043565 PAX familyFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
613065 OMIMLeukemia, acute lymphoblastic, 3 (ALL3)A subtype of acute leukemia, a cancer of the white blood cells. Acute lymphoblastic anemia is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
PAX5_HUMANDAXX_HUMANBioGRID, IntAct11799127 details
PAX5_HUMANCA109_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANMK09_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANGBG13_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANKLH38_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANUBXN7_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANSAE1_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANNGLY1_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANACO12_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANHMGB3_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANCIB3_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANDTX2_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANUBX2B_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANCCNC_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANSTAC_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANCKS1_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANS14L4_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANNFYC_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANRAD52_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANPNMA5_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANKRA93_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANZMYM5_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANSPF27_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANARH_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANLONF1_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANOSGI1_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANHGS_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANHXC8_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANNEIL2_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANTLK2_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANCSK21_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANCDK3_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANFBLN1_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANKR108_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANHMBX1_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANCX038_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANGRHL2_HUMANBioGRID, IntAct32296183 details
PAX5_HUMANUBE3A_HUMANBioGRID, IntAct29426014 details
PAX5_HUMANTLE4_HUMANBioGRID, HPRD10811620 12153506 details
PAX5_HUMANRUNX1_HUMANBioGRID, HPRD10455134 details
PAX5_HUMANEP300_HUMANBioGRID21357426 31941781 details
PAX5_HUMANTBP_HUMANBioGRID, HPRD10197586 details
PAX5_HUMANRB_HUMANBioGRID, HPRD10197586 details
PAX5_HUMANMK01_HUMANBioGRID22593617 details
PAX5_HUMANUBC9_HUMANBioGRID32296183 details
PAX5_HUMANR144B_HUMANBioGRID32296183 details
PAX5_HUMANLARP4_HUMANBioGRID32296183 details
PAX5_HUMANIMA1_HUMANHPRD10748034 details
PAX5_HUMANIMA5_HUMANHPRD10748034 details
PAX5_HUMANCBP_HUMANHPRD11799127 details
PAX5_HUMANKMT2A_HUMANIntAct24735925 details
PAX5_HUMANCDN1B_HUMANBioGRID, IntAct24735925 28158851 details
PAX5_HUMANMYB_HUMANBioGRID, HPRD11781241 details
PAX5_HUMANID3_HUMANBioGRID, HPRD12054881 details
PAX5_HUMANKAT2B_HUMANBioGRID28158851 details
PAX5_HUMANH31_HUMANBioGRID31941781 details
PAX5_HUMANPAX5_HUMANHPRD10022910 details
PAX5_HUMANCOE1_HUMANHPRD14594818 details
PAX5_HUMANID2_HUMANHPRD11134340 details
PAX5_HUMANETS1_HUMANHPRD10022910 12221090 details