Entity Details

Primary name IF4G1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04637
EntryNameIF4G1_HUMAN
FullNameEukaryotic translation initiation factor 4 gamma 1
TaxID9606
Evidenceevidence at protein level
Length1599
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesEIF4G1

GO terms

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GOName
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001662 behavioral fear response
GO:0002191 cap-dependent translational initiation
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0008135 translation factor activity, RNA binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0010494 cytoplasmic stress granule
GO:0010507 negative regulation of autophagy
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010942 positive regulation of cell death
GO:0016020 membrane
GO:0016032 viral process
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0030307 positive regulation of cell growth
GO:0031369 translation initiation factor binding
GO:0031669 cellular response to nutrient levels
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032502 developmental process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034645 cellular macromolecule biosynthetic process
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042802 identical protein binding
GO:0043488 regulation of mRNA stability
GO:0045666 positive regulation of neuron differentiation
GO:0060090 molecular adaptor activity
GO:0060964 regulation of gene silencing by miRNA
GO:0080135 regulation of cellular response to stress
GO:0097009 energy homeostasis
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1901215 negative regulation of neuron death
GO:1905537 positive regulation of eukaryotic translation initiation factor 4F complex assembly
GO:1905606 regulation of presynapse assembly
GO:1905612 positive regulation of mRNA cap binding
GO:1905618 positive regulation of miRNA mediated inhibition of translation
GO:1905696 regulation of polysome binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003307 W2 domainDomainDomain
IPR003890 MIF4G-like, type 3DomainDomain
IPR003891 Initiation factor eIF-4 gamma, MA3DomainDomain
IPR016021 MIF4G-like domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR037584 Eukaryotic translation initiation factor 4 gamma 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
614251 OMIMParkinson disease 18 (PARK18)An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is caused by variants affecting the gene represented in this entry.

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
IF4G1_HUMANPABP1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt12086624 16772376 19716330 26344197 9857202 details
IF4G1_HUMANHSPB1_HUMANHPRD, MINT10859165 details
IF4G1_HUMANMKNK1_HUMANBioGRID, HPRD, MINT15234964 9878069 details
IF4G1_HUMANIF4A1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11408474 16541103 16648488 16932749 17053147 17353931 18606994 19203580 22586265 22939629 23023399 23478064 24768540 26344197 27864334 28514442 29395067 9372926 9418880 details
IF4G1_HUMANIF4E_HUMANBioGRID, DIP, HPRD, IntAct, MINT10600798 10753870 12071973 15153109 15361857 16281055 16541103 16648488 16720573 18955708 20212144 21191102 22509910 22586265 23665581 24981860 25923732 25940091 26186194 26344197 27864334 28514442 29987188 30573685 7651417 9372926 9418880 details
IF4G1_HUMANZFYV9_HUMANBioGRID, HPRD, MINT15231748 details
IF4G1_HUMANANXA5_HUMANHPRD, IntAct16169070 details
IF4G1_HUMANHNRPD_HUMANBioGRID, IntAct10205060 16556936 18573886 26496610 details
IF4G1_HUMANGLPK_HUMANBioGRID, IntAct21988832 details
IF4G1_HUMANCENPU_HUMANBioGRID, MINT21900206 details
IF4G1_HUMANUBE3A_HUMANBioGRID, MINT21900206 details
IF4G1_HUMANDDX3X_HUMANMINT22872150 details
IF4G1_HUMANFXR2_HUMANBioGRID, IntAct, MINT23974796 32296183 details
IF4G1_HUMANCCD57_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANCIB1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANSMRD1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANCDN2D_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANENKD1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANCTBP2_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANATPF2_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANPEF1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANDTX2_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANA1CF_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANIF4G1_HUMANDIP16698552 details
IF4G1_HUMANRBM4_HUMANDIP17284590 details
IF4G1_HUMANMKNK2_HUMANBioGRID12897141 details
IF4G1_HUMANTRAF2_HUMANBioGRID15743837 details
IF4G1_HUMANHTRA2_HUMANBioGRID17266347 details
IF4G1_HUMANSRPK2_HUMANBioGRID26167880 details
IF4G1_HUMANEIF1_HUMANBioGRID29987188 details
IF4G1_HUMANSUMO2_HUMANBioGRID32786267 details
IF4G1_HUMANIF4A2_HUMANBioGRID, HPRD, IntAct, MINT11408474 17353931 24768540 24981860 26344197 29395067 details
IF4G1_HUMANNCBP1_HUMANBioGRID, HPRD, IntAct11340157 15361857 25049393 details
IF4G1_HUMANPDCD4_HUMANBioGRID, HPRD, IntAct12054647 details
IF4G1_HUMANEIF3J_HUMANMINT16932749 details
IF4G1_HUMANCRCM_HUMANIntAct17353931 details
IF4G1_HUMANARF6_HUMANIntAct17353931 details
IF4G1_HUMANPAK2_HUMANHPRD, IntAct16281055 17353931 details
IF4G1_HUMANEPB41_HUMANIntAct17353931 details
IF4G1_HUMANAAKB1_HUMANIntAct17353931 details
IF4G1_HUMANIKKE_HUMANIntAct17353931 details
IF4G1_HUMANTRAF6_HUMANIntAct17353931 details
IF4G1_HUMAN1433Z_HUMANMINT15161933 details
IF4G1_HUMANZ3H7B_HUMANIntAct15047801 details
IF4G1_HUMANG3BP1_HUMANBioGRID, MINT, UniProt18005740 19615732 23209657 26777405 details
IF4G1_HUMANEIF3B_HUMANBioGRID, HPRD, MINT16541103 23023399 24981860 27381497 9418880 details
IF4G1_HUMANEIF3I_HUMANBioGRID, HPRD, IntAct16541103 24981860 26186194 28514442 details
IF4G1_HUMANDISC1_HUMANIntAct31413325 details
IF4G1_HUMANEIF3A_HUMANBioGRID, HPRD16541103 24981860 details
IF4G1_HUMANUBP10_HUMANBioGRID19615732 27003362 27022092 32382008 details
IF4G1_HUMANEIF3H_HUMANBioGRID19615732 24981860 32269044 details
IF4G1_HUMANISG15_HUMANBioGRID16009940 33024031 details
IF4G1_HUMANIF4B_HUMANBioGRID22939629 26344197 27864334 details
IF4G1_HUMANITA4_HUMANBioGRID22623428 details
IF4G1_HUMANBRCA1_HUMANBioGRID23805307 26831064 details
IF4G1_HUMANPDIP3_HUMANBioGRID25049393 details
IF4G1_HUMANSLBP_HUMANBioGRID27773672 details
IF4G1_HUMANOTU6B_HUMANBioGRID27864334 details
IF4G1_HUMANCDC37_HUMANBioGRID16611982 details
IF4G1_HUMANSRSF3_HUMANBioGRID27381497 details
IF4G1_HUMANG3BP2_HUMANBioGRID31114027 details
IF4G1_HUMANIF5_HUMANHPRD11331597 details