Entity Details

Primary name AK1C1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04828
EntryNameAK1C1_HUMAN
FullNameAldo-keto reductase family 1 member C1
TaxID9606
Evidenceevidence at protein level
Length323
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesAKR1C1

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0004033 aldo-keto reductase (NADP) activity
GO:0005829 cytosol
GO:0006693 prostaglandin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007586 digestion
GO:0008202 steroid metabolic process
GO:0008206 bile acid metabolic process
GO:0015721 bile acid and bile salt transport
GO:0016229 steroid dehydrogenase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 phenanthrene 9,10-monooxygenase activity
GO:0030283 testosterone dehydrogenase [NAD(P)] activity
GO:0030299 intestinal cholesterol absorption
GO:0030855 epithelial cell differentiation
GO:0031406 carboxylic acid binding
GO:0032052 bile acid binding
GO:0033703 3beta-hydroxy-5beta-steroid dehydrogenase activity
GO:0035410 dihydrotestosterone 17-beta-dehydrogenase activity
GO:0042448 progesterone metabolic process
GO:0042574 retinal metabolic process
GO:0042632 cholesterol homeostasis
GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0046683 response to organophosphorus
GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
GO:0047023 androsterone dehydrogenase activity
GO:0047024 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO:0047042 androsterone dehydrogenase (B-specific) activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047086 ketosteroid monooxygenase activity
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047718 indanol dehydrogenase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0070062 extracellular exosome
GO:0071395 cellular response to jasmonic acid stimulus
GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR018170 Aldo/keto reductase, conserved siteSiteConserved site
IPR020471 Aldo-keto reductaseFamilyFamily
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily
IPR044482 Aldo-keto reductase family 1 member CFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00461 NabumetoneDrugbanksmall molecule
DB00776 OxcarbazepineDrugbanksmall molecule
DB00936 Salicylic acidDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB03467 NaringeninDrugbanksmall molecule
DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACIDDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB07768 EpitestosteroneDrugbanksmall molecule
DB07931 HexestrolDrugbanksmall molecule
DB12612 OzanimodDrugbanksmall molecule