Entity Details

Primary name BTK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06187
EntryNameBTK_HUMAN
FullNameTyrosine-protein kinase BTK
TaxID9606
Evidenceevidence at protein level
Length659
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesBTK

GO terms

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GOName
GO:0001805 positive regulation of type III hypersensitivity
GO:0001812 positive regulation of type I hypersensitivity
GO:0001818 negative regulation of cytokine production
GO:0002250 adaptive immune response
GO:0002344 B cell affinity maturation
GO:0002553 histamine secretion by mast cell
GO:0002721 regulation of B cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007498 mesoderm development
GO:0016004 phospholipase activator activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0030889 negative regulation of B cell proliferation
GO:0031410 cytoplasmic vesicle
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045579 positive regulation of B cell differentiation
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048469 cell maturation
GO:0048471 perinuclear region of cytoplasm
GO:0050853 B cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071226 cellular response to molecule of fungal origin
GO:0097190 apoptotic signaling pathway
GO:0098761 cellular response to interleukin-7

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001562 Zinc finger, Btk motifSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035574 Tyrosine-protein kinase BTK, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300755 OMIMX-linked agammaglobulinemia (XLA)Humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis in the first few years of life, or even some patients present overwhelming sepsis or meningitis, resulting in death in a few hours. Treatment in most cases is by infusion of intravenous immunoglobulin. The disease is caused by variants affecting the gene represented in this entry.
307200 OMIMGrowth hormone deficiency, isolated, 3, with agammaglobulinemia (IGHD3)An X-linked recessive disorder characterized by growth hormone deficiency, short stature, delayed bone age, agammaglobulinemia with markedly reduced numbers of B cells, and good response to treatment with growth hormone. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB01863 Inositol 1,3,4,5-TetrakisphosphateDrugbanksmall molecule
DB05204 XL418Drugbanksmall molecule
DB09053 IbrutinibDrugbanksmall molecule
DB11703 AcalabrutinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule
DB15327 AbivertinibDrugbanksmall molecule

Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
BTK_HUMANBTK_HUMANBioGRID, HPRD, IntAct, MINT10427990 11231015 11373296 11527964 11577348 11598012 12445832 12573241 29290977 8629002 8630736 details
BTK_HUMANBLNK_HUMANBioGRID, HPRD, MINT10498607 10556826 12093870 16969585 21482705 21822214 details
BTK_HUMAN3BP5_HUMANBioGRID, HPRD, IntAct10339589 9571151 details
BTK_HUMANGTF2I_HUMANBioGRID, HPRD, IntAct, MINT10373551 11313464 11373296 11934902 14623887 15096481 19214191 9012831 9837922 details
BTK_HUMANIBTK_HUMANBioGRID, HPRD, IntAct11577348 18596081 21482705 details
BTK_HUMANMED28_HUMANBioGRID, MINT16964398 details
BTK_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
BTK_HUMANGRB2_HUMANBioGRID, IntAct19380743 20936779 details
BTK_HUMANARRB1_HUMANBioGRID, IntAct21988832 details
BTK_HUMANUROK_HUMANBioGRID, IntAct21988832 details
BTK_HUMANANDR_HUMANBioGRID, IntAct24728074 details
BTK_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
BTK_HUMANMET_HUMANBioGRID, IntAct24728074 details
BTK_HUMANP55G_HUMANBioGRID, IntAct25814554 details
BTK_HUMANBECN1_HUMANBioGRID, IntAct25814554 details
BTK_HUMANRT22_HUMANBioGRID, IntAct25814554 details
BTK_HUMANWASP_HUMANbhf-ucl, BioGRID, HPRD10068673 10427990 12235133 12769846 8892607 9742969 details
BTK_HUMANMEOX2_HUMANBioGRID, IntAct25910212 details
BTK_HUMANGPVI_HUMANDIP19940238 details
BTK_HUMANADA15_HUMANUniProt25825872 details
BTK_HUMANKPCB_HUMANBioGRID, HPRD11598012 12679936 details
BTK_HUMANKPCD1_HUMANBioGRID, HPRD10561498 details
BTK_HUMANKHDR1_HUMANBioGRID, HPRD22745667 9201297 details
BTK_HUMANKS6B1_HUMANBioGRID16640565 details
BTK_HUMANKS6B2_HUMANBioGRID16640565 details
BTK_HUMANFYN_HUMANBioGRID8058772 details
BTK_HUMANLYN_HUMANBioGRID, HPRD11226282 11598012 8058772 8629002 8630736 details
BTK_HUMANHCK_HUMANBioGRID, HPRD8058772 details
BTK_HUMANRHG17_HUMANBioGRID, HPRD11431473 details
BTK_HUMANCBL_HUMANBioGRID, HPRD10427990 10826882 7629518 9408950 details
BTK_HUMANGNAQ_HUMANBioGRID, HPRD9770463 details
BTK_HUMANB2L11_HUMANBioGRID15096481 details
BTK_HUMANTLR8_HUMANBioGRID, HPRD12724322 details
BTK_HUMANTLR4_HUMANBioGRID, HPRD12724322 details
BTK_HUMANTLR6_HUMANBioGRID, HPRD12724322 details
BTK_HUMANTLR9_HUMANBioGRID, HPRD12724322 details
BTK_HUMANA4_HUMANBioGRID21832049 details
BTK_HUMANSTA5A_HUMANBioGRID, HPRD11413148 7925280 8617237 details
BTK_HUMANSMUF1_HUMANBioGRID20804422 details
BTK_HUMANAURKA_HUMANBioGRID28218735 details
BTK_HUMANMDM2_HUMANBioGRID29290977 details
BTK_HUMANCOASY_HUMANBioGRID19763791 details
BTK_HUMANERBB3_HUMANBioGRID22973453 details
BTK_HUMANFCERG_HUMANIntAct11788586 details
BTK_HUMANKPCT_HUMANHPRD, IntAct11788586 details
BTK_HUMANARI3A_HUMANBioGRID, HPRD, MINT15203319 19214191 details
BTK_HUMANCD19_HUMANHPRD, MINT10201980 19214191 details
BTK_HUMANMAL_HUMANInnateDB22366891 details
BTK_HUMANHS90B_HUMANIntAct22939624 details
BTK_HUMANHS90A_HUMANBioGRID, IntAct22939624 28514442 details
BTK_HUMANCAV1_HUMANBioGRID, HPRD11751885 details
BTK_HUMANJAK1_HUMANBioGRID, HPRD9178903 details
BTK_HUMANVAV_HUMANBioGRID, HPRD9201297 details
BTK_HUMANEWS_HUMANBioGRID, HPRD9201297 details
BTK_HUMANPLCG2_HUMANBioGRID, HPRD10981967 11507089 12093870 17290227 details
BTK_HUMANCBLB_HUMANBioGRID12093870 details
BTK_HUMANMYD88_HUMANBioGRID, HPRD12724322 details
BTK_HUMANTIRAP_HUMANBioGRID, HPRD12724322 16415872 16439361 details
BTK_HUMANIRAK1_HUMANBioGRID, HPRD12724322 details
BTK_HUMANGBB1_HUMANBioGRID11698416 details
BTK_HUMANKSYK_HUMANBioGRID, HPRD10427990 11226282 11598012 8629002 8630736 details
BTK_HUMANCOR1C_HUMANBioGRID21080425 details
BTK_HUMANP53_HUMANBioGRID, HPRD15355990 32807901 details
BTK_HUMANITK_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
BTK_HUMANKPCZ_HUMANHPRD11788586 7522330 details
BTK_HUMANKPCE_HUMANHPRD11788586 7522330 details
BTK_HUMANKPCA_HUMANHPRD11788586 7522330 details
BTK_HUMANABL1_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
BTK_HUMANBMX_HUMANHPRD12573241 details
BTK_HUMANTEC_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
BTK_HUMANGNA12_HUMANHPRD9796816 details
BTK_HUMANWASF2_HUMANHPRD10427990 details
BTK_HUMANSH2B2_HUMANHPRD10872802 details
BTK_HUMANGBG2_HUMANHPRD11698416 7972043 details
BTK_HUMANDAPP1_HUMANHPRD11524430 details
BTK_HUMANTF65_HUMANHPRD15849198 details
BTK_HUMANKIT_HUMANHPRD15007095 details
BTK_HUMANPLCG1_HUMANHPRD15184383 details
BTK_HUMANPI42B_HUMANHPRD14614850 15046600 details
BTK_HUMANPI51A_HUMANHPRD14614850 15046600 details
BTK_HUMANTR10A_HUMANHPRD15007095 details
BTK_HUMANPI51C_HUMANHPRD14614850 15046600 details
BTK_HUMANBCAP_HUMANHPRD11163197 details
BTK_HUMANPI42A_HUMANHPRD14614850 15046600 details
BTK_HUMANPI42C_HUMANHPRD14614850 15046600 details
BTK_HUMANCKLF3_HUMANHPRD15087455 details
BTK_HUMANTNR6_HUMANHPRD9751072 details