Entity Details

Primary name PPARA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07869
EntryNamePPARA_HUMAN
FullNamePeroxisome proliferator-activated receptor alpha
TaxID9606
Evidenceevidence at protein level
Length468
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesPPARA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 transcription coactivator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006631 fatty acid metabolic process
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0008544 epidermis development
GO:0009267 cellular response to starvation
GO:0009755 hormone-mediated signaling pathway
GO:0010565 regulation of cellular ketone metabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010876 lipid localization
GO:0010887 negative regulation of cholesterol storage
GO:0010891 negative regulation of sequestering of triglyceride
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019902 phosphatase binding
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031624 ubiquitin conjugating enzyme binding
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032091 negative regulation of protein binding
GO:0032099 negative regulation of appetite
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0033993 response to lipid
GO:0035095 behavioral response to nicotine
GO:0042060 wound healing
GO:0042157 lipoprotein metabolic process
GO:0042752 regulation of circadian rhythm
GO:0043565 sequence-specific DNA binding
GO:0044877 protein-containing complex binding
GO:0045070 positive regulation of viral genome replication
GO:0045471 response to ethanol
GO:0045722 positive regulation of gluconeogenesis
GO:0045776 negative regulation of blood pressure
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045923 positive regulation of fatty acid metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0050728 negative regulation of inflammatory response
GO:0051525 NFAT protein binding
GO:0051898 negative regulation of protein kinase B signaling
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0070166 enamel mineralization
GO:0097371 MDM2/MDM4 family protein binding
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1901215 negative regulation of neuron death
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903944 negative regulation of hepatocyte apoptotic process
GO:2000191 regulation of fatty acid transport
GO:2000272 negative regulation of signaling receptor activity
GO:2001171 positive regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003074 Peroxisome proliferator-activated receptorFamilyFamily
IPR003076 Peroxisome proliferator-activated receptor alphaFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00132 alpha-Linolenic acidDrugbanksmall molecule
DB00159 IcosapentDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00573 FenoprofenDrugbanksmall molecule
DB00636 ClofibrateDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01241 GemfibrozilDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB01890 N,N-Bis(3-(D-gluconamido)propyl)deoxycholamideDrugbanksmall molecule
DB02266 Flufenamic acidDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB03017 Lauric acidDrugbanksmall molecule
DB03193 Stearic acidDrugbanksmall molecule
DB03756 DoconexentDrugbanksmall molecule
DB03796 Palmitic AcidDrugbanksmall molecule
DB04224 Oleic AcidDrugbanksmall molecule
DB04519 Caprylic acidDrugbanksmall molecule
DB04557 Arachidonic AcidDrugbanksmall molecule
DB04971 ReglitazarDrugbanksmall molecule
DB05187 ElafibranorDrugbanksmall molecule
DB05416 CardarineDrugbanksmall molecule
DB06510 MuraglitazarDrugbanksmall molecule
DB06521 ErtiprotafibDrugbanksmall molecule
DB06533 RagaglitazarDrugbanksmall molecule
DB06536 TesaglitazarDrugbanksmall molecule
DB07215 GW-590735Drugbanksmall molecule
DB07724 IndeglitazarDrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB08915 AleglitazarDrugbanksmall molecule
DB09006 ClinofibrateDrugbanksmall molecule
DB09064 CiprofibrateDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09422 Soybean oilDrugbankbiotech
DB11133 Omega-3 fatty acidsDrugbanksmall molecule
DB11605 MyrrhDrugbanksmall molecule
DB12007 IsoflavoneDrugbanksmall molecule
DB12961 Leukotriene B4Drugbanksmall molecule
DB13873 Fenofibric acidDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech

Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
PPARA_HUMANNCOR2_HUMANbhf-ucl, BioGRID, MINT11845213 19955185 details
PPARA_HUMANRXRG_HUMANBioGRID, IntAct16169070 22205725 details
PPARA_HUMANCHD9_HUMANBioGRID, UniProt16554032 details
PPARA_HUMANCDK3_HUMANBioGRID, IntAct21988832 details
PPARA_HUMANFOXA3_HUMANBioGRID, IntAct21988832 details
PPARA_HUMANLTOR5_HUMANBioGRID, IntAct23414517 details
PPARA_HUMANANM8_HUMANBioGRID, MINT23455924 details
PPARA_HUMANANM1_HUMANBioGRID, MINT23455924 details
PPARA_HUMANUBC9_HUMANbhf-ucl, BioGRID19955185 details
PPARA_HUMANNCOR1_HUMANbhf-ucl, BioGRID, IntAct10336495 11903058 15870285 18292238 19955185 21775429 details
PPARA_HUMANGRB2_HUMANBioGRID, IntAct25814554 details
PPARA_HUMANP55G_HUMANBioGRID, IntAct25814554 details
PPARA_HUMANNCOA1_HUMANBioGRID, IntAct10731636 12163133 15888456 21775429 9407140 9626662 details
PPARA_HUMANPRGC1_HUMANBioGRID, IntAct10669761 21775429 details
PPARA_HUMANCBP_HUMANIntAct21775429 details
PPARA_HUMANNCOA2_HUMANBioGRID, IntAct15888456 21775429 details
PPARA_HUMANNR1H3_HUMANBioGRID, DIP15722453 24713062 8621574 details
PPARA_HUMANNR1H2_HUMANBioGRID, DIP15722453 details
PPARA_HUMANALBU_HUMANIntAct32814053 details
PPARA_HUMANCASP6_HUMANIntAct32814053 details
PPARA_HUMANCCKN_HUMANIntAct32814053 details
PPARA_HUMANFGFR3_HUMANIntAct32814053 details
PPARA_HUMANNMDE3_HUMANIntAct32814053 details
PPARA_HUMANGELS_HUMANIntAct32814053 details
PPARA_HUMANLAMP2_HUMANIntAct32814053 details
PPARA_HUMANRD23A_HUMANIntAct32814053 details
PPARA_HUMANRAN_HUMANIntAct32814053 details
PPARA_HUMANTGFR2_HUMANIntAct32814053 details
PPARA_HUMANTERA_HUMANIntAct32814053 details
PPARA_HUMANCBX5_HUMANIntAct32814053 details
PPARA_HUMANJPH3_HUMANIntAct32814053 details
PPARA_HUMANSPRE1_HUMANIntAct32814053 details
PPARA_HUMANHD_HUMANIntAct32814053 details
PPARA_HUMANNRBF2_HUMANBioGRID10786636 details
PPARA_HUMANSTAC3_HUMANBioGRID16189514 32296183 details
PPARA_HUMANGA45G_HUMANBioGRID10872826 details
PPARA_HUMANEP300_HUMANBioGRID10336495 18797151 9407140 details
PPARA_HUMANRT29_HUMANBioGRID10903152 details
PPARA_HUMANFABPL_HUMANBioGRID11226238 details
PPARA_HUMANMECR_HUMANBioGRID9795230 details
PPARA_HUMANTF65_HUMANBioGRID10542237 details
PPARA_HUMANNRIP1_HUMANBioGRID9626662 details
PPARA_HUMANPRGC2_HUMANBioGRID11733490 details
PPARA_HUMANAKP13_HUMANBioGRID9627117 details
PPARA_HUMANPIT1_HUMANBioGRID11891224 details
PPARA_HUMANHELZ2_HUMANBioGRID12189208 details
PPARA_HUMANRXRA_HUMANBioGRID10195690 12562861 15888456 22205725 23711995 details
PPARA_HUMANMED24_HUMANBioGRID9653119 details
PPARA_HUMANHS90A_HUMANBioGRID12482853 12962497 details
PPARA_HUMANAIP_HUMANBioGRID12482853 details
PPARA_HUMANSTP1_HUMANBioGRID21967852 details
PPARA_HUMANSIR1_HUMANBioGRID19356714 details
PPARA_HUMANNCOA3_HUMANBioGRID15888456 details
PPARA_HUMANCE350_HUMANBioGRID15615782 details
PPARA_HUMANBCL2_HUMANBioGRID26556865 details
PPARA_HUMANUB2R1_HUMANBioGRID26556865 details
PPARA_HUMANPAQR3_HUMANBioGRID29331071 details
PPARA_HUMANHXC8_HUMANBioGRID32296183 details
PPARA_HUMANFBLN1_HUMANBioGRID32296183 details
PPARA_HUMANPICK1_HUMANBioGRID32296183 details
PPARA_HUMANCHIC2_HUMANBioGRID32296183 details
PPARA_HUMANVMA5A_HUMANBioGRID32296183 details
PPARA_HUMANSDCB1_HUMANBioGRID32296183 details
PPARA_HUMANCO8A1_HUMANBioGRID32296183 details
PPARA_HUMANANR11_HUMANBioGRID32296183 details
PPARA_HUMANF90A1_HUMANBioGRID32296183 details
PPARA_HUMANVWC2L_HUMANBioGRID32296183 details
PPARA_HUMANFAM9B_HUMANBioGRID32296183 details
PPARA_HUMANEXOS4_HUMANBioGRID32296183 details
PPARA_HUMANCTNA3_HUMANBioGRID32296183 details
PPARA_HUMANZSC23_HUMANBioGRID32296183 details
PPARA_HUMANZN587_HUMANBioGRID32296183 details
PPARA_HUMANGPAN1_HUMANBioGRID32296183 details
PPARA_HUMANKR101_HUMANBioGRID32296183 details
PPARA_HUMANAQP1_HUMANBioGRID32296183 details
PPARA_HUMANKCTD7_HUMANBioGRID32296183 details
PPARA_HUMANCC179_HUMANBioGRID32296183 details
PPARA_HUMANTRI55_HUMANBioGRID31391242 details
PPARA_HUMANTRI63_HUMANBioGRID31391242 details
PPARA_HUMANANM2_HUMANIntAct12039952 details
PPARA_HUMANMED1_HUMANUniProt9653119 details
PPARA_HUMANLPIN1_HUMANBioGRID20385772 details
PPARA_HUMANRXRB_HUMANBioGRID22205725 details
PPARA_HUMANSTAT1_HUMANBioGRID26504087 details
PPARA_HUMANHUWE1_HUMANBioGRID29331071 details
PPARA_HUMANVHL_HUMANBioGRID32589900 details