Entity Details

Primary name DDR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08345
EntryNameDDR1_HUMAN
FullNameEpithelial discoidin domain-containing receptor 1
TaxID9606
Evidenceevidence at protein level
Length913
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesDDR1

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0001952 regulation of cell-matrix adhesion
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007566 embryo implantation
GO:0007595 lactation
GO:0008285 negative regulation of cell population proliferation
GO:0010715 regulation of extracellular matrix disassembly
GO:0014909 smooth muscle cell migration
GO:0030198 extracellular matrix organization
GO:0033674 positive regulation of kinase activity
GO:0038062 protein tyrosine kinase collagen receptor activity
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0043235 receptor complex
GO:0043583 ear development
GO:0044319 wound healing, spreading of cells
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060749 mammary gland alveolus development
GO:0061302 smooth muscle cell-matrix adhesion
GO:0061564 axon development
GO:0070062 extracellular exosome
GO:1990138 neuron projection extension

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000421 Coagulation factor 5/8 C-terminal domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR034299 Discoidin domain-containing receptor 1/2FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00619 ImatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule