Entity Details

Primary name FOXO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12778
EntryNameFOXO1_HUMAN
FullNameForkhead box protein O1
TaxID9606
Evidenceevidence at protein level
Length655
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesFOXO1

GO terms

Show/Hide Table
GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001659 temperature homeostasis
GO:0001678 cellular glucose homeostasis
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006473 protein acetylation
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008013 beta-catenin binding
GO:0008286 insulin receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0010508 positive regulation of autophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0032869 cellular response to insulin stimulus
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034599 cellular response to oxidative stress
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045444 fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051721 protein phosphatase 2A binding
GO:0070166 enamel mineralization
GO:0070301 cellular response to hydrogen peroxide
GO:0070417 cellular response to cold
GO:0070542 response to fatty acid
GO:0071455 cellular response to hyperoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:0097009 energy homeostasis
GO:1902617 response to fluoride
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
GO:2000074 regulation of type B pancreatic cell development

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032067 FOXO protein, transactivation domainDomainDomain
IPR032068 FOXO protein, KIX-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
FOXO1_HUMANESR1_HUMANBioGRID, HPRD, IntAct11353774 11435445 22266855 details
FOXO1_HUMANCDK1_HUMANIntAct18408765 details
FOXO1_HUMANANDR_HUMANBioGRID, HPRD, IntAct12482965 17202144 details
FOXO1_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT11237865 28205554 28514442 details
FOXO1_HUMANFHL2_HUMANBioGRID, HPRD, UniProt15692560 details
FOXO1_HUMANCBP_HUMANBioGRID, HPRD, MINT, UniProt10973497 15220471 16154098 24419059 25609649 details
FOXO1_HUMANAKT1_HUMANBioGRID, DIP, HPRD, IntAct10358014 10358075 16076959 18786403 25241761 31844113 details
FOXO1_HUMANSET_HUMANBioGRID, MINT24983498 27626385 details
FOXO1_HUMANEP300_HUMANBioGRID, MINT11896584 15890677 18786403 24419059 25609649 details
FOXO1_HUMAN1433G_HUMANBioGRID, HPRD, IntAct11237865 28205554 28514442 details
FOXO1_HUMANSTK4_HUMANDIP18786403 details
FOXO1_HUMANETS1_HUMANIntAct24419615 details
FOXO1_HUMANTSC2_HUMANBioGRID17077083 details
FOXO1_HUMANCEBPB_HUMANBioGRID, HPRD11893744 details
FOXO1_HUMANHXA5_HUMANBioGRID, HPRD12163409 details
FOXO1_HUMANHNF4A_HUMANBioGRID, HPRD12519792 19740748 details
FOXO1_HUMANPARP1_HUMANBioGRID19281796 details
FOXO1_HUMANLPPRC_HUMANBioGRID17050673 details
FOXO1_HUMANSKP2_HUMANBioGRID15668399 19686743 28802579 30535125 details
FOXO1_HUMANSIR2_HUMANBioGRID15220471 20543840 24419059 details
FOXO1_HUMANMDM2_HUMANBioGRID19321440 27412556 details
FOXO1_HUMANRARA_HUMANBioGRID, HPRD11353774 details
FOXO1_HUMANHGFL_HUMANBioGRID18786403 details
FOXO1_HUMANNCOA1_HUMANBioGRID10973497 details
FOXO1_HUMANP55G_HUMANBioGRID25814554 details
FOXO1_HUMANTNS2_HUMANBioGRID25814554 details
FOXO1_HUMANKAPCA_HUMANBioGRID21177856 details
FOXO1_HUMANPITX1_HUMANBioGRID24065703 details
FOXO1_HUMANEHMT2_HUMANBioGRID30535125 details
FOXO1_HUMANDACH1_HUMANBioGRID28205554 details
FOXO1_HUMAN1433S_HUMANBioGRID28205554 details
FOXO1_HUMANNED4L_HUMANBioGRID31844113 details
FOXO1_HUMANCTNB1_HUMANHPRD15905404 details
FOXO1_HUMANPPARG_HUMANHPRD12966085 details
FOXO1_HUMANSIR1_HUMANBioGRID, DIP, HPRD, UniProt15220471 15692560 16154098 18235501 22013015 details
FOXO1_HUMANGSK3B_HUMANBioGRID, HPRD, IntAct11980723 25241761 details
FOXO1_HUMANSMAD4_HUMANBioGRID, HPRD, IntAct15084259 details
FOXO1_HUMAN1433T_HUMANBioGRID, IntAct24419059 28514442 details
FOXO1_HUMAN1433B_HUMANBioGRID, IntAct16919273 28514442 details
FOXO1_HUMANSMAD3_HUMANBioGRID, HPRD15084259 details
FOXO1_HUMANCOP1_HUMANBioGRID18815134 details
FOXO1_HUMANHXA11_HUMANBioGRID19727442 details
FOXO1_HUMANPML_HUMANBioGRID16154098 details
FOXO1_HUMANATG7_HUMANBioGRID20543840 22622204 23640897 30689742 details
FOXO1_HUMANCHIP_HUMANBioGRID19483080 details
FOXO1_HUMANNLK_HUMANBioGRID20874444 details
FOXO1_HUMANFSHR_HUMANBioGRID17030088 details
FOXO1_HUMANIRF3_HUMANBioGRID23532851 details
FOXO1_HUMANCRY1_HUMANBioGRID27412556 28790135 details
FOXO1_HUMANSIR7_HUMANBioGRID28655758 details
FOXO1_HUMANATM_HUMANBioGRID27559048 details
FOXO1_HUMANMYH9_HUMANBioGRID31754475 details
FOXO1_HUMANSMAG2_HUMANBioGRID29395067 details
FOXO1_HUMANFOXG1_HUMANHPRD15084259 details
FOXO1_HUMANTHB_HUMANHPRD11353774 details
FOXO1_HUMANHXA10_HUMANHPRD12493691 details
FOXO1_HUMANSRC_HUMANHPRD10973497 details
FOXO1_HUMANG6PC1_HUMANHPRD11672436 details
FOXO1_HUMANPAK1_HUMANHPRD10358014 12560069 details
FOXO1_HUMANDYR1A_HUMANHPRD11311120 details