Entity Details

Primary name CHEK1
Entity type gene
Source Source Link

Details

PrimaryID1111
RefseqGeneNG_030049
SymbolCHEK1
Namecheckpoint kinase 1
Chromosome11
Location11q24.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-04-21
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsCHK1_HUMAN

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000785 chromatin
GO:0000794 condensed nuclear chromosome
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0018107 peptidyl-threonine phosphorylation
GO:0019904 protein domain specific binding
GO:0032991 protein-containing complex
GO:0035402 histone kinase activity (H3-T11 specific)
GO:0035556 intracellular signal transduction
GO:0043231 intracellular membrane-bounded organelle
GO:0044818 mitotic G2/M transition checkpoint
GO:0045787 positive regulation of cell cycle
GO:0045839 negative regulation of mitotic nuclear division
GO:0046602 regulation of mitotic centrosome separation
GO:0048096 chromatin-mediated maintenance of transcription
GO:0070317 negative regulation of G0 to G1 transition
GO:0071260 cellular response to mechanical stimulus
GO:0090399 replicative senescence
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:2000615 regulation of histone H3-K9 acetylation

Diseases

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Interactions

149 interactions

InteractorPartnerSourcesPublicationsLink
CHEK1CSNK2BHPRD, MINT12902976 15225637 details
CHEK1MDM4BioGRID, HPRD, MINT16163388 16511572 details
CHEK1TP53BioGRID, HPRD, MINT10673501 11551930 11709713 11896572 12756247 15364958 16511572 9765199 details
CHEK1CDC25CBioGRID, HPRD, IntAct, UniProt10557092 10681541 11016625 11333986 11390642 11551930 11836499 12660173 15705874 16330544 16705183 17035231 19330022 29735693 32357935 9278511 9278512 details
CHEK1AATFHPRD, IntAct17157788 details
CHEK1CDC25ABioGRID, HPRD, IntAct12399544 12676583 12759351 12963847 17292828 18480045 27432908 9278511 details
CHEK1RB1BioGRID, MINT17380128 details
CHEK1CLSPNBioGRID, HPRD, IntAct12766152 16123041 16963448 23109433 details
CHEK1BRCA1BioGRID, UniProt11836499 17380128 details
CHEK1YWHAGHPRD, MINT15324660 20639859 details
CHEK1PIGMBioGRID, IntAct21988832 details
CHEK1ERRFI1MINT22505024 details
CHEK1SMURF1IntAct25249323 details
CHEK1ATRBioGRID, DIP, HPRD10608806 11252893 11390642 15775976 17686975 19330022 21566061 32357935 details
CHEK1CSNK2A1BioGRID12902976 15225637 details
CHEK1TP53BP1BioGRID15364958 17984114 details
CHEK1XIAPBioGRID, HPRD14759516 details
CHEK1ATMBioGRID, HPRD10608806 11252893 11390642 12676583 details
CHEK1PRKDCBioGRID10608806 12756247 details
CHEK1CDC25BBioGRID9278511 details
CHEK1MCPH1BioGRID16783362 details
CHEK1XPO1BioGRID12676962 details
CHEK1FANCEBioGRID17296736 details
CHEK1USP7BioGRID21845734 25086746 25483066 26296656 31601781 32447346 details
CHEK1HSP90AA1BioGRID, HPRD16330544 21566061 22939624 details
CHEK1LATS2BioGRID21118956 23886938 details
CHEK1MEPEBioGRID19808933 details
CHEK1TLK1BioGRID, HPRD12660173 12955071 details
CHEK1APPBioGRID21832049 details
CHEK1RELABioGRID, HPRD15775976 details
CHEK1DTLBioGRID23109433 23533280 details
CHEK1TOPBP1BioGRID17686975 details
CHEK1RAD23ABioGRID26296656 details
CHEK1UBA1BioGRID26296656 details
CHEK1UBA2BioGRID26296656 details
CHEK1FANCD2BioGRID19861535 details
CHEK1UBE2TBioGRID28162934 details
CHEK1BCL2L1BioGRID22617334 details
CHEK1ILKAPBioGRID29371914 details
CHEK1ATXN3BioGRID28180282 details
CHEK1CNTN2BioGRID15107832 details
CHEK1USP3BioGRID29735693 details
CHEK1MCM2BioGRID25049228 details
CHEK1MCM6BioGRID25049228 details
CHEK1MCM7BioGRID25049228 details
CHEK1BRCA2BioGRID18317453 details
CHEK1PRKAA1BioGRID30428154 details
CHEK1MAPTBioGRID20159774 details
CHEK1FZR1BioGRID32345958 details
CHEK1TRAF4BioGRID32357935 details
CHEK1HDAC6BioGRID33020410 details
CHEK1HSP90AB1IntAct16330544 22939624 details
CHEK1CUL1BioGRID, HPRD, MINT16137618 17290223 19808933 23109433 30428154 details
CHEK1TIMELESSBioGRID, HPRD, IntAct15798197 details
CHEK1YWHABMINT20639859 details
CHEK1YWHAZMINT20639859 details
CHEK1ATRIPMINT20639859 details
CHEK1RPA2MINT20639859 details
CHEK1MEN1BioGRID, MINT20969866 details
CHEK1RAD51BioGRID, HPRD, UniProt15665856 22665067 details
CHEK1KAT5IntAct22863007 details
CHEK1CEP164IntAct22863007 details
CHEK1SRSF2IntAct22863007 details
CHEK1KSR1BioGRID, IntAct27173435 unassigned1312 details
CHEK1SH3PXD2ABioGRID, IntAct27173435 unassigned1312 details
CHEK1EIF4E2BioGRID, IntAct27173435 unassigned1312 details
CHEK1SRGAP2BioGRID, IntAct27173435 unassigned1312 details
CHEK1DENND1ABioGRID, IntAct27173435 unassigned1312 details
CHEK1KIF13BBioGRID, IntAct27173435 unassigned1312 details
CHEK1LRFN1BioGRID, IntAct27173435 unassigned1312 details
CHEK1ZBTB21BioGRID, IntAct27173435 unassigned1312 details
CHEK1CBY1BioGRID, IntAct27173435 unassigned1312 details
CHEK1KCTD3BioGRID, IntAct27173435 unassigned1312 details
CHEK1MSH2BioGRID15647386 details
CHEK1SFNBioGRID11896572 details
CHEK1CDKN1ABioGRID11896572 details
CHEK1BLMBioGRID, HPRD15364958 details
CHEK1XRCC6BioGRID, HPRD12756247 details
CHEK1XRCC5BioGRID12756247 details
CHEK1MSH6BioGRID20029092 details
CHEK1POLA1BioGRID19177015 details
CHEK1PCNABioGRID18448427 details
CHEK1DNMT1BioGRID17991895 20940144 details
CHEK1DDB1BioGRID19276361 23109433 25024738 28192407 details
CHEK1CUL4ABioGRID, HPRD16137618 19276361 19808933 23109433 details
CHEK1FEM1BBioGRID19330022 details
CHEK1NEK2BioGRID15311285 details
CHEK1BTG3BioGRID23533280 29735693 details
CHEK1SETMARBioGRID25024738 details
CHEK1ZEB1BioGRID25086746 details
CHEK1NFATC1BioGRID27637333 details
CHEK1NFATC2BioGRID27637333 details
CHEK1FBXO6BioGRID28180282 details
CHEK1H3C6BioGRID29760279 details
CHEK1MCM3BioGRID25049228 details
CHEK1MCM4BioGRID25049228 details
CHEK1MCM5BioGRID25049228 details
CHEK1CDC45BioGRID25049228 details
CHEK1GINS1BioGRID25049228 details
CHEK1BTRCBioGRID30428154 details
CHEK1NFKB1BioGRID33024116 details
CHEK1UBBHPRD16137618 details
CHEK1SMAD4HPRD15761153 details
CHEK1CHUKHPRD17962807 details
CHEK1AKT1HPRD12062056 details
CHEK1SLX4IntAct19596235 details
CHEK1SNW1BioGRID, MINT20467437 details
CHEK1CDC5LBioGRID, MINT20467437 details
CHEK1SQSTM1IntAct20562859 details
CHEK1NEK9BioGRID, IntAct20562859 details
CHEK1COPS5BioGRID, IntAct21145461 details
CHEK1PKMIntAct24606918 details
CHEK1PPP1R15AIntAct29109149 details
CHEK1FUSBioGRID, IntAct25852190 details
CHEK1JUNMINT25609649 details
CHEK1CDK1BioGRID, IntAct26496610 details
CHEK1CHRNA9BioGRID, IntAct26186194 28514442 details
CHEK1IL13RA2BioGRID, IntAct28514442 details
CHEK1LDLRAP1BioGRID, IntAct26186194 28514442 details
CHEK1VAV1BioGRID, IntAct28514442 details
CHEK1NELL1BioGRID, IntAct28514442 details
CHEK1BCL2L14BioGRID, IntAct26186194 28514442 details
CHEK1PLA2G10BioGRID, IntAct28514442 details
CHEK1CTSEBioGRID, IntAct28514442 details
CHEK1TCEAL1BioGRID, IntAct26186194 28514442 details
CHEK1ERCC6LBioGRID, IntAct28514442 details
CHEK1HLA-DRB5BioGRID, IntAct26186194 28514442 details
CHEK1DNAAF11BioGRID, IntAct28514442 details
CHEK1UNC5CLBioGRID, IntAct28514442 details
CHEK1NAT9BioGRID, IntAct28514442 details
CHEK1RACGAP1BioGRID, IntAct28514442 details
CHEK1SNX11BioGRID, IntAct26186194 28514442 details
CHEK1PRKCBBioGRID, IntAct31980649 details
CHEK1MED15BioGRID22939629 details
CHEK1VCPBioGRID23383273 details
CHEK1HECW2BioGRID24163370 details
CHEK1TNRC6BBioGRID24778252 details
CHEK1L3HYPDHBioGRID26186194 details
CHEK1HNRNPDBioGRID26344197 details
CHEK1MAPK1BioGRID26344197 details
CHEK1PPM1ABioGRID26344197 details
CHEK1PTBP1BioGRID26344197 details
CHEK1PTBP3BioGRID26344197 details
CHEK1TARS1BioGRID26344197 details
CHEK1MTMR4BioGRID28675297 details
CHEK1PLEKHA4BioGRID31091453 details
CHEK1BRD8BioGRID31753913 details
CHEK1TRIM33BioGRID31753913 details
CHEK1CLPBBioGRID32877691 details