Entity Details

Primary name NR1H3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13133
EntryNameNR1H3_HUMAN
FullNameOxysterols receptor LXR-alpha
TaxID9606
Evidenceevidence at protein level
Length447
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesNR1H3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008270 zinc ion binding
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0015485 cholesterol binding
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032369 negative regulation of lipid transport
GO:0032376 positive regulation of cholesterol transport
GO:0032570 response to progesterone
GO:0032810 sterol response element binding
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0042632 cholesterol homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043031 negative regulation of macrophage activation
GO:0043235 receptor complex
GO:0043277 apoptotic cell clearance
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048550 negative regulation of pinocytosis
GO:0050728 negative regulation of inflammatory response
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0055088 lipid homeostasis
GO:0055092 sterol homeostasis
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0070328 triglyceride homeostasis
GO:0071222 cellular response to lipopolysaccharide
GO:0090188 negative regulation of pancreatic juice secretion
GO:0090341 negative regulation of secretion of lysosomal enzymes
GO:0090575 RNA polymerase II transcription regulator complex
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1903573 negative regulation of response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR023257 Liver X receptorFamilyFamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07080 TO-901317Drugbanksmall molecule
DB07929 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDEDrugbanksmall molecule
DB08063 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONEDrugbanksmall molecule
DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACIDDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB13174 RheinDrugbanksmall molecule

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
NR1H3_HUMANEDF1_HUMANBioGRID, HPRD, IntAct12040021 details
NR1H3_HUMANNCOA1_HUMANBioGRID, MINT15604093 20682316 25962847 details
NR1H3_HUMANRXRA_HUMANBioGRID, DIP, HPRD, MINT12117567 15604093 15722453 20682316 8621574 9013544 details
NR1H3_HUMANRXRG_HUMANBioGRID, HPRD, IntAct, MINT15604093 21516116 25416956 25910212 31515488 32296183 details
NR1H3_HUMANMSTO1_HUMANBioGRID, IntAct21988832 details
NR1H3_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
NR1H3_HUMANSUV91_HUMANBioGRID, MINT23455924 details
NR1H3_HUMANRXRB_HUMANBioGRID, HPRD, IntAct15604093 25416956 26871637 32296183 details
NR1H3_HUMANMDFI_HUMANBioGRID, IntAct25416956 25910212 32296183 details
NR1H3_HUMANNCOR2_HUMANIntAct26120082 details
NR1H3_HUMANNCOR1_HUMANBioGRID, HPRD, IntAct12663743 15604093 26120082 details
NR1H3_HUMANMED1_HUMANIntAct26120082 details
NR1H3_HUMANGPAN1_HUMANBioGRID, IntAct32296183 details
NR1H3_HUMANBAG3_HUMANBioGRID, IntAct32296183 details
NR1H3_HUMANPPARA_HUMANBioGRID, DIP15722453 24713062 8621574 details
NR1H3_HUMANPPARD_HUMANBioGRID, DIP15722453 details
NR1H3_HUMANPPARG_HUMANBioGRID, DIP15722453 details
NR1H3_HUMANLMNA_HUMANIntAct32814053 details
NR1H3_HUMANSPRE1_HUMANIntAct32814053 details
NR1H3_HUMANHD_HUMANIntAct32814053 details
NR1H3_HUMANLZTR1_HUMANBioGRID, IntAct20211142 details
NR1H3_HUMANCREST_HUMANBioGRID, IntAct20211142 details
NR1H3_HUMANNR0B2_HUMANBioGRID, HPRD12198243 27485016 details
NR1H3_HUMANZXDC_HUMANBioGRID15604093 details
NR1H3_HUMANKAT2B_HUMANBioGRID15604093 details
NR1H3_HUMANNCOA3_HUMANBioGRID, HPRD15604093 details
NR1H3_HUMANNCOA6_HUMANBioGRID, HPRD12724417 15604093 details
NR1H3_HUMANACTN1_HUMANBioGRID, HPRD15604093 details
NR1H3_HUMANFOXO3_HUMANBioGRID, HPRD15604093 details
NR1H3_HUMANNRIP1_HUMANBioGRID, HPRD10022764 15604093 details
NR1H3_HUMANT161A_HUMANBioGRID, HPRD15604093 details
NR1H3_HUMANING3_HUMANBioGRID, HPRD15604093 details
NR1H3_HUMANGCR_HUMANBioGRID22457708 details
NR1H3_HUMANA4_HUMANBioGRID21832049 details
NR1H3_HUMANCE350_HUMANBioGRID15615782 details
NR1H3_HUMANPRS8_HUMANBioGRID15604093 details
NR1H3_HUMANUBC9_HUMANBioGRID27485016 details
NR1H3_HUMANSYT1_HUMANHPRD16143103 details
NR1H3_HUMANHS90B_HUMANIntAct22939624 details
NR1H3_HUMANMLF1_HUMANIntAct25036637 details
NR1H3_HUMANFKBP5_HUMANIntAct25036637 details
NR1H3_HUMANPTG3L_HUMANIntAct25036637 details
NR1H3_HUMANAASD1_HUMANIntAct25036637 details
NR1H3_HUMANFKBPL_HUMANIntAct25036637 details
NR1H3_HUMANMEN1_HUMANMINT25962847 details
NR1H3_HUMANBARD1_HUMANBioGRID19164445 24009820 details
NR1H3_HUMANSIR1_HUMANBioGRID, HPRD17936707 details
NR1H3_HUMANPIAS1_HUMANBioGRID22969086 details
NR1H3_HUMANHS90A_HUMANBioGRID22939624 details
NR1H3_HUMANCCND1_HUMANBioGRID27485016 details
NR1H3_HUMANBBS5_HUMANBioGRID27485016 details
NR1H3_HUMANSTAT1_HUMANBioGRID27485016 details
NR1H3_HUMANHDAC4_HUMANBioGRID27485016 details
NR1H3_HUMANRARA_HUMANHPRD10022764 details