Entity Details

Primary name PAK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13177
EntryNamePAK2_HUMAN
FullNameSerine/threonine-protein kinase PAK 2
TaxID9606
Evidenceevidence at protein level
Length524
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPAK2

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0014069 postsynaptic density
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030296 protein tyrosine kinase activator activity
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031267 small GTPase binding
GO:0031295 T cell costimulation
GO:0032147 activation of protein kinase activity
GO:0034333 adherens junction assembly
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0040008 regulation of growth
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0045296 cadherin binding
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050690 regulation of defense response to virus by virus
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050770 regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051493 regulation of cytoskeleton organization
GO:0051497 negative regulation of stress fiber assembly
GO:0060996 dendritic spine development
GO:0070830 bicellular tight junction assembly
GO:0071407 cellular response to organic cyclic compound
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0150105 protein localization to cell-cell junction
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033923 p21 activated kinase binding domainDomainDomain
IPR035064 p21-activated kinase 2, catalytic domainDomainDomain
IPR035065 Serine/threonine-protein kinase PAK2FamilyFamily
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

100 interactions

InteractorPartnerSourcesPublicationsLink
PAK2_HUMANSRC_HUMANBioGRID, HPRD, MINT12215529 16374509 details
PAK2_HUMANHCK_HUMANBioGRID, HPRD, MINT16374509 details
PAK2_HUMANLYN_HUMANHPRD, MINT16374509 details
PAK2_HUMANYES_HUMANHPRD, MINT16374509 details
PAK2_HUMANFYN_HUMANHPRD, MINT16374509 details
PAK2_HUMANSPD2A_HUMANHPRD, MINT16374509 details
PAK2_HUMANGRB2_HUMANHPRD, MINT16374509 details
PAK2_HUMANARHG7_HUMANBioGRID, HPRD, IntAct, MINT12226077 16374509 16787945 26496610 32203420 details
PAK2_HUMANARHG6_HUMANBioGRID, HPRD, IntAct, MINT16374509 28514442 32203420 32296183 details
PAK2_HUMANNCK1_HUMANBioGRID, HPRD, IntAct, MINT11160719 16374509 32296183 details
PAK2_HUMANSRBS2_HUMANHPRD, MINT16374509 details
PAK2_HUMANVINEX_HUMANBioGRID, HPRD, IntAct, MINT16374509 21516116 25416956 details
PAK2_HUMANSRBS1_HUMANHPRD, MINT16374509 details
PAK2_HUMANSH3R3_HUMANBioGRID, HPRD, MINT16374509 details
PAK2_HUMANSH3R1_HUMANHPRD, MINT16374509 details
PAK2_HUMANCDC42_HUMANBioGRID, HPRD, IntAct10320322 16204230 17353931 20696164 20936779 21311754 25416956 32296183 9535855 9822598 details
PAK2_HUMANLIMK1_HUMANHPRD, IntAct16837009 details
PAK2_HUMANRAF1_HUMANBioGRID, HPRD, IntAct15886202 16837009 details
PAK2_HUMANPAK2_HUMANBioGRID, HPRD, IntAct10075701 16837009 7673144 9786869 details
PAK2_HUMANSRC8_HUMANMINT18344974 details
PAK2_HUMANRAC1_HUMANBioGRID, HPRD, IntAct, MINT19264842 20696164 20936779 22705156 9535855 details
PAK2_HUMANACK1_HUMANMINT20696164 details
PAK2_HUMANBRAF_HUMANBioGRID, IntAct20936779 details
PAK2_HUMANDYST_HUMANBioGRID, IntAct20936779 details
PAK2_HUMANEP300_HUMANBioGRID, IntAct20936779 details
PAK2_HUMANRIOK3_HUMANBioGRID, IntAct21988832 details
PAK2_HUMANCASP7_HUMANIntAct21555521 details
PAK2_HUMANRHOJ_HUMANBioGRID, IntAct25416956 26186194 28514442 32296183 details
PAK2_HUMANABI2_HUMANBioGRID, IntAct32296183 details
PAK2_HUMANNCK2_HUMANBioGRID, IntAct26186194 28514442 32296183 details
PAK2_HUMANSH3K1_HUMANBioGRID, HPRD12829691 details
PAK2_HUMANABI3_HUMANBioGRID, HPRD11956071 details
PAK2_HUMANMLRV_HUMANBioGRID, HPRD10047984 details
PAK2_HUMANDOCK2_HUMANBioGRID12176041 details
PAK2_HUMANRAC2_HUMANBioGRID12176041 details
PAK2_HUMANABL1_HUMANBioGRID, HPRD11121037 details
PAK2_HUMANH4_HUMANBioGRID21724829 details
PAK2_HUMANLCK_HUMANBioGRID, HPRD16374509 details
PAK2_HUMANA4_HUMANBioGRID21832049 details
PAK2_HUMANMYC_HUMANBioGRID14749374 16081735 details
PAK2_HUMANPPM1A_HUMANBioGRID18586681 details
PAK2_HUMANOGT1_HUMANBioGRID32994395 details
PAK2_HUMANRHG10_HUMANHPRD15471851 details
PAK2_HUMANGSTM3_HUMANIntAct17353931 details
PAK2_HUMANUB2V1_HUMANIntAct17353931 details
PAK2_HUMANSEPT2_HUMANIntAct17353931 details
PAK2_HUMANPGRC1_HUMANIntAct17353931 details
PAK2_HUMANSODM_HUMANIntAct17353931 details
PAK2_HUMANPSA1_HUMANIntAct17353931 details
PAK2_HUMANCSDE1_HUMANIntAct17353931 details
PAK2_HUMANPEBP1_HUMANIntAct17353931 details
PAK2_HUMANPIN1_HUMANIntAct17353931 details
PAK2_HUMANCALR_HUMANIntAct17353931 details
PAK2_HUMAN2ABB_HUMANIntAct17353931 details
PAK2_HUMANBTF3_HUMANIntAct17353931 details
PAK2_HUMANGDIB_HUMANIntAct17353931 details
PAK2_HUMANPSB7_HUMANIntAct17353931 details
PAK2_HUMANRL24_HUMANIntAct17353931 details
PAK2_HUMANAPEX1_HUMANIntAct17353931 details
PAK2_HUMANANXA2_HUMANIntAct17353931 details
PAK2_HUMANIF4E_HUMANIntAct17353931 details
PAK2_HUMANTIF1B_HUMANIntAct17353931 details
PAK2_HUMANCPSF6_HUMANIntAct17353931 details
PAK2_HUMANIF4G1_HUMANHPRD, IntAct16281055 17353931 details
PAK2_HUMANPIMT_HUMANIntAct17353931 details
PAK2_HUMANPDIA1_HUMANIntAct17353931 details
PAK2_HUMANSAHH_HUMANIntAct17353931 details
PAK2_HUMANECHM_HUMANIntAct17353931 details
PAK2_HUMANKAD2_HUMANIntAct17353931 details
PAK2_HUMANNUDC_HUMANIntAct17353931 details
PAK2_HUMANPPAC_HUMANIntAct17353931 details
PAK2_HUMANGANAB_HUMANIntAct17353931 details
PAK2_HUMANPSD13_HUMANIntAct17353931 details
PAK2_HUMANEIF3I_HUMANIntAct17353931 details
PAK2_HUMANPSA2_HUMANIntAct17353931 details
PAK2_HUMANRL32_HUMANIntAct17353931 details
PAK2_HUMANAATM_HUMANIntAct17353931 details
PAK2_HUMANRL23A_HUMANIntAct17353931 details
PAK2_HUMANRAP1B_HUMANIntAct17353931 details
PAK2_HUMANHD_HUMANIntAct19240112 details
PAK2_HUMANMKNK1_HUMANBioGRID, HPRD, IntAct15234964 25241761 details
PAK2_HUMANCASP3_HUMANBioGRID, HPRD, IntAct16204230 25241761 9786869 details
PAK2_HUMANDISC1_HUMANIntAct31413325 details
PAK2_HUMANBIP_HUMANBioGRID15908432 details
PAK2_HUMANMK03_HUMANBioGRID, HPRD12226077 26344197 details
PAK2_HUMANMK14_HUMANBioGRID18586681 details
PAK2_HUMANPP1A_HUMANBioGRID23828041 details
PAK2_HUMANPP1B_HUMANBioGRID23828041 details
PAK2_HUMANRS6_HUMANHPRD1985906 details
PAK2_HUMANVIME_HUMANHPRD11895474 2500966 details
PAK2_HUMANSYN1_HUMANHPRD10571231 12237306 details
PAK2_HUMANMYLK_HUMANHPRD10748018 2160950 details
PAK2_HUMANABI1_HUMANHPRD11956071 details
PAK2_HUMANMK01_HUMANHPRD15031289 details
PAK2_HUMANSNX9_HUMANHPRD16374509 details
PAK2_HUMANSNX33_HUMANHPRD16374509 details
PAK2_HUMANNPHP1_HUMANHPRD16374509 details
PAK2_HUMANPACN3_HUMANHPRD16374509 details
PAK2_HUMANSH3G2_HUMANHPRD16374509 details
PAK2_HUMANIF4B_HUMANHPRD16281055 details