Entity Details

Primary name CBLB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13191
EntryNameCBLB_HUMAN
FullNameE3 ubiquitin-protein ligase CBL-B
TaxID9606
Evidenceevidence at protein level
Length982
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesCBLB

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002669 positive regulation of T cell anergy
GO:0005509 calcium ion binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006607 NLS-bearing protein import into nucleus
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
GO:0018193 peptidyl-amino acid modification
GO:0030971 receptor tyrosine kinase binding
GO:0031398 positive regulation of protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0042110 T cell activation
GO:0043087 regulation of GTPase activity
GO:0043393 regulation of protein binding
GO:0045121 membrane raft
GO:0045732 positive regulation of protein catabolic process
GO:0046642 negative regulation of alpha-beta T cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0061630 ubiquitin protein ligase activity
GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR003153 Adaptor protein Cbl, N-terminal helicalDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR014741 Adaptor protein Cbl, EF hand-likeDomainDomain
IPR014742 Adaptor protein Cbl, SH2-like domainDomainDomain
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR024159 Adaptor protein Cbl, PTB domainDomainDomain
IPR024162 Adaptor protein CblFamilyFamily
IPR036537 Adaptor protein Cbl, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039520 E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclassDomainDomain

Diseases

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Interactions

97 interactions

InteractorPartnerSourcesPublicationsLink
CBLB_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10022120 10086340 12577067 20936779 21706016 21900206 25416956 26264872 27107012 28514442 29997244 31467278 31980649 32814053 9614102 details
CBLB_HUMANARHG7_HUMANBioGRID, HPRD, MINT12935897 16228008 details
CBLB_HUMANRNF11_HUMANBioGRID, HPRD, MINT15231748 details
CBLB_HUMANSH3K1_HUMANBioGRID, DIP, HPRD, IntAct, MINT12177062 12218189 12829691 12874286 16228008 17020880 18680311 19268472 19531213 23663663 32296183 details
CBLB_HUMANEGFR_HUMANBioGRID, DIP, HPRD, IntAct10086340 10635327 11375397 15657067 16702950 16729043 18271526 19531499 20308550 24797263 28572092 30515972 31959764 details
CBLB_HUMANGORS2_HUMANBioGRID, HPRD, IntAct16189514 25416956 31515488 32296183 details
CBLB_HUMANCRY1_HUMANBioGRID, HPRD, IntAct16189514 details
CBLB_HUMANNCK2_HUMANBioGRID, HPRD, IntAct16189514 21516116 25416956 26186194 26871637 28514442 details
CBLB_HUMANVINEX_HUMANBioGRID, HPRD, IntAct16189514 details
CBLB_HUMANSRC_HUMANMINT17094785 details
CBLB_HUMANCD2AP_HUMANBioGRID, MINT17020880 23663663 details
CBLB_HUMANCRK_HUMANBioGRID, IntAct19380743 25814554 details
CBLB_HUMANABI1_HUMANMINT20598684 details
CBLB_HUMANCRKL_HUMANBioGRID, HPRD, IntAct, MINT10022120 25814554 details
CBLB_HUMANDP13A_HUMANBioGRID, IntAct25814554 details
CBLB_HUMANGRAP2_HUMANBioGRID, IntAct25814554 details
CBLB_HUMANFYN_HUMANBioGRID, HPRD, IntAct16503409 25814554 32296183 details
CBLB_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
CBLB_HUMANGLRX3_HUMANBioGRID, IntAct25416956 details
CBLB_HUMANUBS3B_HUMANBioGRID, IntAct25416956 32296183 details
CBLB_HUMANANM2_HUMANBioGRID, IntAct26871637 details
CBLB_HUMANSRBS2_HUMANBioGRID, IntAct32296183 details
CBLB_HUMANVP26C_HUMANBioGRID, IntAct32296183 details
CBLB_HUMANVAV3_HUMANBioGRID, IntAct32296183 details
CBLB_HUMANUBS3A_HUMANBioGRID, IntAct31659016 32296183 details
CBLB_HUMANPTK6_HUMANBioGRID, IntAct32296183 details
CBLB_HUMANYES_HUMANBioGRID, IntAct32296183 details
CBLB_HUMANUB2D2_HUMANBioGRID, DIP22158902 29326975 29643511 details
CBLB_HUMANLRRK2_HUMANBioGRID, IntAct29513927 32814053 details
CBLB_HUMANDAPK1_HUMANBioGRID, IntAct29513927 details
CBLB_HUMANMFHA1_HUMANBioGRID, IntAct29513927 details
CBLB_HUMANNEDD8_HUMANBioGRID, MINT30659753 details
CBLB_HUMANNC2B_HUMANIntAct32814053 details
CBLB_HUMANTF2B_HUMANIntAct32814053 details
CBLB_HUMANMERL_HUMANIntAct32814053 details
CBLB_HUMANTF3C3_HUMANIntAct32814053 details
CBLB_HUMANDNJB6_HUMANIntAct32814053 details
CBLB_HUMANSODC_HUMANIntAct32814053 details
CBLB_HUMANFUS_HUMANIntAct32814053 details
CBLB_HUMANTADBP_HUMANIntAct32814053 details
CBLB_HUMANNEDD4_HUMANBioGRID, HPRD12907674 details
CBLB_HUMANVAV_HUMANBioGRID, HPRD11857085 9399639 details
CBLB_HUMANKSYK_HUMANBioGRID, HPRD10022120 12771181 27428901 details
CBLB_HUMANUBC_HUMANBioGRID14661060 16007098 18596201 19285159 19880507 30659753 31699778 details
CBLB_HUMANCBLB_HUMANBioGRID11375397 22158902 details
CBLB_HUMANVAV2_HUMANBioGRID9399639 details
CBLB_HUMANHNRPK_HUMANBioGRID9399639 details
CBLB_HUMANTGFI1_HUMANBioGRID23145173 details
CBLB_HUMANSP7_HUMANBioGRID25744063 details
CBLB_HUMANUB2L3_HUMANBioGRID29643511 details
CBLB_HUMANOSTF1_HUMANBioGRID32296183 details
CBLB_HUMANSH3R1_HUMANBioGRID32296183 details
CBLB_HUMANASAP1_HUMANBioGRID, MINT17255943 details
CBLB_HUMANASAP2_HUMANMINT17255943 details
CBLB_HUMANCFLAR_HUMANBioGRID, MINT22884570 details
CBLB_HUMANDDR2_HUMANBioGRID, MINT24631539 26826182 details
CBLB_HUMANNCK1_HUMANHPRD, MINT16503409 25218436 details
CBLB_HUMANCAR11_HUMANBioGRID, DIP19815501 details
CBLB_HUMANNR2C2_HUMANDIP19815501 details
CBLB_HUMANZAP70_HUMANBioGRID, HPRD10074432 21453975 details
CBLB_HUMANSHC1_HUMANBioGRID, HPRD9614102 details
CBLB_HUMANP85A_HUMANBioGRID, HPRD10022120 10086340 11526404 19190244 9614102 details
CBLB_HUMANBTK_HUMANBioGRID12093870 details
CBLB_HUMANPLCG2_HUMANBioGRID, HPRD12093870 details
CBLB_HUMANKIT_HUMANBioGRID, HPRD12177062 15315962 details
CBLB_HUMANIRS1_HUMANBioGRID16734387 29729186 details
CBLB_HUMANITSN1_HUMANBioGRID18539136 details
CBLB_HUMANFCERB_HUMANBioGRID16002993 details
CBLB_HUMANMYD88_HUMANBioGRID20639876 details
CBLB_HUMANTCAM1_HUMANBioGRID20639876 details
CBLB_HUMANPTN11_HUMANBioGRID17330819 details
CBLB_HUMANTANK_HUMANBioGRID17878343 details
CBLB_HUMANTRAF3_HUMANBioGRID17878343 details
CBLB_HUMANTRAF6_HUMANBioGRID17878343 details
CBLB_HUMANLCK_HUMANBioGRID21453975 details
CBLB_HUMANP85B_HUMANBioGRID19190244 details
CBLB_HUMANCBL_HUMANBioGRID19380743 27048651 details
CBLB_HUMANSPY1_HUMANBioGRID19915061 details
CBLB_HUMANWASP_HUMANBioGRID23684068 details
CBLB_HUMANFAK2_HUMANBioGRID25099615 details
CBLB_HUMANSIR2_HUMANBioGRID25285640 details
CBLB_HUMANNTRK1_HUMANBioGRID25921289 details
CBLB_HUMANPGFRB_HUMANBioGRID27048651 details
CBLB_HUMANTR10B_HUMANBioGRID28972304 details
CBLB_HUMANTRAF2_HUMANBioGRID28972304 details
CBLB_HUMANCYLD_HUMANBioGRID28572092 details
CBLB_HUMANFAK1_HUMANBioGRID27446403 32158232 details
CBLB_HUMANZO1_HUMANBioGRID30024968 details
CBLB_HUMANP53_HUMANBioGRID29940895 details
CBLB_HUMANSTA5A_HUMANBioGRID30367831 details
CBLB_HUMANNLRP3_HUMANBioGRID31999304 details
CBLB_HUMANBLNK_HUMANHPRD12093870 details
CBLB_HUMANSPY2_HUMANHPRD11053437 details
CBLB_HUMANRET_HUMANHPRD16525057 details
CBLB_HUMANFYB1_HUMANHPRD16503409 details
CBLB_HUMANTNR11_HUMANHPRD11406619 details
CBLB_HUMANFLT3_HUMANHPRD9614102 details