Entity Details

Primary name NFAC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13469
EntryNameNFAC2_HUMAN
FullNameNuclear factor of activated T-cells, cytoplasmic 2
TaxID9606
Evidenceevidence at protein level
Length925
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesNFATC2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0014904 myotube cell development
GO:0016477 cell migration
GO:0019902 phosphatase binding
GO:0030890 positive regulation of B cell proliferation
GO:0033173 calcineurin-NFAT signaling cascade
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0045589 regulation of regulatory T cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050853 B cell receptor signaling pathway
GO:1901741 positive regulation of myoblast fusion
GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002909 IPT domainDomainDomain
IPR008366 Nuclear factor of activated T cells (NFAT)FamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR011539 Rel homology domain (RHD), DNA-binding domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR032397 Rel homology dimerisation domainDomainDomain
IPR037059 Rel homology domain (RHD), DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
NFAC2_HUMANMED31_HUMANBioGRID, HPRD, IntAct16169070 details
NFAC2_HUMANVIME_HUMANBioGRID, HPRD, IntAct16169070 details
NFAC2_HUMANVRK2_HUMANIntAct23105117 details
NFAC2_HUMANJUN_HUMANBioGRID, IntAct, MINT20557936 25609649 27637333 details
NFAC2_HUMANNFAC2_HUMANBioGRID, DIP, HPRD12949493 18462673 19060202 details
NFAC2_HUMANCBP_HUMANBioGRID, DIP, HPRD19060202 9625762 details
NFAC2_HUMANPP2BA_HUMANDIP24954618 details
NFAC2_HUMANKPCZ_HUMANBioGRID, HPRD12021260 details
NFAC2_HUMANPIN1_HUMANBioGRID, HPRD11356192 details
NFAC2_HUMANMEF2D_HUMANBioGRID, HPRD10944115 details
NFAC2_HUMANTAF9_HUMANBioGRID, HPRD10821850 details
NFAC2_HUMANI2BP2_HUMANBioGRID21576369 27637333 details
NFAC2_HUMANNF2IP_HUMANHPRD8943202 details
NFAC2_HUMANRIPK2_HUMANIntAct17353931 details
NFAC2_HUMANLRRK2_HUMANBioGRID, InnateDB21983832 details
NFAC2_HUMANUBP22_HUMANBioGRID, MINT24561192 details
NFAC2_HUMANCREB1_HUMANBioGRID, MINT25609649 27637333 details
NFAC2_HUMANFOXP3_HUMANBioGRID, HPRD, IntAct15790681 16517728 19564342 details
NFAC2_HUMANFOS_HUMANBioGRID, DIP18172215 27637333 details
NFAC2_HUMANEP300_HUMANBioGRID, HPRD27637333 9625762 details
NFAC2_HUMANIRF4_HUMANBioGRID, HPRD11956291 details
NFAC2_HUMANMK09_HUMANBioGRID15184502 15958558 details
NFAC2_HUMANMK08_HUMANBioGRID15184502 details
NFAC2_HUMANSUV91_HUMANBioGRID22079596 details
NFAC2_HUMANTBA1A_HUMANBioGRID21278340 details
NFAC2_HUMANIMB1_HUMANBioGRID21278340 details
NFAC2_HUMANGBB2_HUMANBioGRID23326349 details
NFAC2_HUMANIKZF1_HUMANBioGRID27637333 details
NFAC2_HUMANRPTOR_HUMANBioGRID27637333 details
NFAC2_HUMANCHK1_HUMANBioGRID27637333 details
NFAC2_HUMANSCAI_HUMANBioGRID27637333 details
NFAC2_HUMANIKZF2_HUMANBioGRID27637333 details
NFAC2_HUMANGSK3B_HUMANBioGRID27637333 details
NFAC2_HUMANRUNX1_HUMANBioGRID27637333 details
NFAC2_HUMANSATB1_HUMANBioGRID27637333 details
NFAC2_HUMANWDR48_HUMANBioGRID27637333 details
NFAC2_HUMANEGR1_HUMANBioGRID, HPRD12560487 27637333 details
NFAC2_HUMAN1433T_HUMANBioGRID, HPRD10611249 27637333 details
NFAC2_HUMAN1433Z_HUMANBioGRID, HPRD10611249 27637333 details
NFAC2_HUMANPP2BB_HUMANHPRD11030334 9660947 details
NFAC2_HUMANCANB1_HUMANHPRD16473827 details
NFAC2_HUMANEGR4_HUMANHPRD12560487 details